公开(公告)号：US20110224748A1

公开(公告)日：2011-09-15

申请号：US13041025

申请日：2011-03-04

申请人： Michael LIPPERT ,  Michael Vollkron ,  Gerald Czygan ,  Stefan Paule

发明人： Michael LIPPERT ,  Michael Vollkron ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61N1/39 ,  A61B5/02 ,  A61N1/365

CPC分类号： A61B5/0205 ,  A61B5/02028 ,  A61B5/6846 ,  A61B5/7275 ,  A61N1/365 ,  A61N1/3702 ,  G06F19/00

摘要： A monitoring device for a patient for predicting a cardiovascular anomaly and a method for operating a monitoring device is provided. Furthermore, an implantable electrotherapy device, such as an implantable cardiac pacemaker, an implantable cardioverter, or an implantable defibrillator, having a monitoring device are also provided. In an embodiment, the monitoring device acquires a value change of a hemodynamic parameter, which occurs as a result of a detected value change of a state parameter, for example, as a result of an activation or deactivation of a cardiac resynchronization therapy. By suitable evaluation of the value change of the hemodynamic parameter, the monitoring device can output an evaluation result signal which is indicative of an imminence of a cardiovascular anomaly, such as a cardiac decompensation, long beforehand and with high specificity.

摘要翻译： 提供了一种用于预测心血管异常的患者的监测装置和用于操作监测装置的方法。 此外，还提供了具有监测装置的可植入电疗设备，例如可植入心脏起搏器，植入式心律转复器或可植入除颤器。 在一个实施例中，监测装置获取血液动力学参数的值变化，其作为状态参数的检测值变化的结果，例如作为心脏再同步治疗的激活或停用的结果而发生。 通过对血液动力学参数的值变化的适当评价，监视装置可以预先长时间地以高特异性输出表示心血管异常的心血管异常现象的评价结果​​信号，例如心脏代偿失调。

公开(公告)号：US08939904B2

公开(公告)日：2015-01-27

申请号：US13041025

申请日：2011-03-04

申请人： Michael Lippert ,  Michael Vollkron ,  Gerald Czygan ,  Stefan Paule

发明人： Michael Lippert ,  Michael Vollkron ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/02 ,  A61B5/0205 ,  A61B5/00 ,  A61N1/37 ,  A61N1/365

CPC分类号： A61B5/0205 ,  A61B5/02028 ,  A61B5/6846 ,  A61B5/7275 ,  A61N1/365 ,  A61N1/3702 ,  G06F19/00

摘要： A monitoring device for a patient for predicting a cardiovascular anomaly and a method for operating a monitoring device is provided. Furthermore, an implantable electrotherapy device, such as an implantable cardiac pacemaker, an implantable cardioverter, or an implantable defibrillator, having a monitoring device are also provided. In an embodiment, the monitoring device acquires a value change of a hemodynamic parameter, which occurs as a result of a detected value change of a state parameter, for example, as a result of an activation or deactivation of a cardiac resynchronization therapy. By suitable evaluation of the value change of the hemodynamic parameter, the monitoring device can output an evaluation result signal which is indicative of an imminence of a cardiovascular anomaly, such as a cardiac decompensation, long beforehand and with high specificity.

摘要翻译： 提供了一种用于预测心血管异常的患者的监测装置和用于操作监测装置的方法。 此外，还提供了具有监测装置的可植入电疗设备，例如可植入心脏起搏器，植入式心律转复器或可植入除颤器。 在一个实施例中，监测装置获取血液动力学参数的值变化，其作为状态参数的检测值变化的结果，例如作为心脏再同步治疗的激活或停用的结果而发生。 通过对血液动力学参数的值变化的适当评价，监视装置可以预先长时间地以高特异性输出表示心血管异常的心血管异常现象的评价结果​​信号，例如心脏代偿失调。

公开(公告)号：US20100268294A1

公开(公告)日：2010-10-21

申请号：US12749723

申请日：2010-03-30

申请人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

发明人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61N1/365 ,  G06N5/02 ,  G06F11/07 ,  G06F17/00 ,  A61B5/021 ,  A61B5/0452 ,  A61N1/39

CPC分类号： A61N1/3627 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/053 ,  A61B5/1076 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36564 ,  A61N1/36578

摘要： Embodiments relate to a heart monitor, which is connected to or can be connected to at least one sensor for pressure and volume data or equivalent substitute variables and which comprises an evaluation unit for processing at least one input signal reflecting the temporal course of pressure and volume data or equivalent substitute variables of the heart. The evaluation unit is configured such that it segments the input signal in accordance with individual completed cardiac cycles and examines segments of the input signal obtained in this way as to whether a particular segment of the input signal represents a PV diagram, which corresponds to specified quality conditions regarding the direction of circulation, morphology and distance between a starting and end values.

摘要翻译： 实施例涉及心脏监测器，心脏监测器连接到或可以连接至至少一个用于压力和体积数据或等效替代变量的传感器，并且其包括用于处理反映压力和体积的时间过程的至少一个输入信号的评估单元 数据或等效替代变量的心脏。 评估单元被配置为使得其根据各个完成的心动周期来分段输入信号，并且检查以这种方式获得的输入信号的段是关于输入信号的特定段是否表示对应于指定质量的PV图 关于循环方向，形态以及起始和终点之间的距离的条件。

公开(公告)号：US08521265B2

公开(公告)日：2013-08-27

申请号：US12749723

申请日：2010-03-30

申请人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

发明人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61B5/04

CPC分类号： A61N1/3627 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/053 ,  A61B5/1076 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36564 ,  A61N1/36578

摘要： Embodiments relate to a heart monitor, which is connected to or can be connected to at least one sensor for pressure and volume data or equivalent substitute variables and which comprises an evaluation unit for processing at least one input signal reflecting the temporal course of pressure and volume data or equivalent substitute variables of the heart. The evaluation unit is configured such that it segments the input signal in accordance with individual completed cardiac cycles and examines segments of the input signal obtained in this way as to whether a particular segment of the input signal represents a PV diagram, which corresponds to specified quality conditions regarding the direction of circulation, morphology and distance between a starting and end values.

摘要翻译： 实施例涉及心脏监测器，心脏监测器连接到或可以连接至至少一个用于压力和体积数据或等效替代变量的传感器，并且其包括用于处理反映压力和体积的时间过程的至少一个输入信号的评估单元 数据或等效替代变量的心脏。 评估单元被配置为使得其根据各个完成的心动周期来分段输入信号，并且检查以这种方式获得的输入信号的段是关于输入信号的特定段是否表示对应于指定质量的PV图 关于循环方向，形态以及起始和终点之间的距离的条件。

公开(公告)号：US20110112598A1

公开(公告)日：2011-05-12

申请号：US12941767

申请日：2010-11-08

申请人： Michael Vollkron ,  Thomas Kraemer ,  Michael Lippert ,  Gerald Czygan

发明人： Michael Vollkron ,  Thomas Kraemer ,  Michael Lippert ,  Gerald Czygan

IPC分类号： A61N1/08 ,  A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/3684

摘要： A biventricular cardiac stimulator is disclosed, comprising a right ventricular stimulation unit, a left ventricular stimulation unit, and a pacemaker timer. In order to detect the effect of a particular atrioventricular delay time (AVD) and a particular interventricular delay time (VVD), the cardiac stimulator has a detector for sensing a hemodynamic benefit. To optimize AVD and VVD, the pacemaker timer is connected to a memory for a particular instantaneous value for the atrioventricular delay time (AVDinst) and the interventricular delay time (VVDinst), and may be used to trigger at certain points in time at least one right ventricular trigger signal and one left ventricular trigger signal, based on new values for the atrioventricular delay time (AVDtest) and the interventricular delay time (VVDtest) which differ from the instantaneous values for the atrioventricular delay time (AVDinst) and the interventricular delay time (VVDinst).

摘要翻译： 公开了一种双心室心脏刺激器，其包括右心室刺激单元，左心室刺激单元和起搏器计时器。 为了检测特定房室延迟时间（AVD）和特定室间延迟时间（VVD）的影响，心脏刺激器具有用于感测血液动力学益处的检测器。 为了优化AVD和VVD，起搏器定时器连接到存储器用于房室延迟时间（AVDinst）和室间延迟时间（VVDinst）的特定瞬时值，并且可以用于在某些时间点触发至少一个 基于房室延迟时间（AVDtest）和室间延迟时间（VVDtest）的新值，与房室延迟时间（AVDinst）和心室间延迟时间（AVDinst）的瞬时值不同的右心室触发信号和一个左心室触发信号 （VVDinst）。

公开(公告)号：US07883469B2

公开(公告)日：2011-02-08

申请号：US11517155

申请日：2006-09-07

申请人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

发明人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/0452

CPC分类号： A61B5/0535 ,  A61B5/7239 ,  A61N1/36521

摘要： A device for detecting the state of a heart on the basis of intracardial impedance measurement. The device has an impedance measuring unit, which has electrical terminals, configured to be electrically connected or to be connected to electrodes for delivering and detecting a current or voltage, and is implemented to ascertain an impedance on the basis of the dimension of the delivered current or voltage and the voltage drop caused by the current or the current caused by the voltage, as well as an analysis unit, which is connected to the impedance measuring unit and is implemented to derive a cardiac function parameter from a time curve of the impedance ascertained using the impedance measuring unit. The analysis unit analyzes the impedance curve assigned to a diastole and derives a cardiac function parameter characterizing the behavior of a heart during the diastole (filling phase of the ventricle).

摘要翻译： 一种用于基于心内阻抗测量来检测心脏状态的装置。 该装置具有阻抗测量单元，其具有电端子，其被配置为电连接或连接到用于传送和检测电流或电压的电极，并且被实现为基于所传送的电流的尺寸来确定阻抗 或电压以及由电压引起的电流或电流导致的电压降以及分析单元，该分析单元连接到阻抗测量单元，并被实现为从所确定的阻抗的时间曲线导出心脏功能参数 使用阻抗测量单元。 分析单元分析舒张期的阻抗曲线，得出表征心脏舒张期（心室充盈期）心脏功能的参数。

公开(公告)号：US08792970B2

公开(公告)日：2014-07-29

申请号：US12389719

申请日：2009-02-20

申请人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan ,  Stefan Paule

发明人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/04 ,  A61B5/08 ,  A61N1/365 ,  A61B5/053 ,  A61N1/372

CPC分类号： A61B5/0809 ,  A61B5/0535 ,  A61N1/36521 ,  A61N1/37258

摘要： A system which generates a warning signal in the event of looming pulmonary edema and/or looming decompensation. The system has an impedance detection unit for determining impedance values, which represent a transthoracic impedance course, and an impedance analysis unit (78), which is connected to the impedance detection unit. The impedance analysis unit (78) is implemented to determine the degree of modulation for a particular impedance course detected by the impedance detection unit.

摘要翻译： 在发生肺水肿和/或逼近失代偿的情况下产生警告信号的系统。 系统具有阻抗检测单元，用于确定表示经胸阻抗路线的阻抗值，以及阻抗分析单元（78），其连接到阻抗检测单元。 阻抗分析单元（78）被实现以确定由阻抗检测单元检测到的特定阻抗进程的调制度。

公开(公告)号：US08271085B2

公开(公告)日：2012-09-18

申请号：US11970662

申请日：2008-01-08

申请人： Michael Lippert ,  Olaf Skerl ,  Stefan Paule ,  Bernhard Fahn ,  Gerald Czygan ,  Heinrich Reinke ,  Albrecht Urbaszek

发明人： Michael Lippert ,  Olaf Skerl ,  Stefan Paule ,  Bernhard Fahn ,  Gerald Czygan ,  Heinrich Reinke ,  Albrecht Urbaszek

IPC分类号： A61N1/365

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/14535 ,  A61B5/7207

摘要： An implantable medical device has an impedance or admittance determination unit, an alternating current or voltage source, a measuring unit, and an analysis unit which is connected to the alternating current or AC voltage source and the measuring unit to calculate an impedance value or an admittance value at different times. The impedance or admittance determination unit may generate measuring current having two different frequencies (preferably below 100 kHz), and the analysis unit may calculate pairs of impedance or admittance values which are chronologically assigned to one another for different frequencies of the measuring current, and calculate a value for a blood impedance or blood admittance component which is independent of the impedance of the body tissue surrounding a particular blood vessel, The analysis unit may also determine trends in this value over time as an indicator for a change of blood hematocrit value.

摘要翻译： 可植入医疗装置具有阻抗或导纳确定单元，交流或电压源，测量单元和分析单元，其连接到交流电压源或交流电压源和测量单元以计算阻抗值或导纳 价值在不同的时间。 阻抗或导纳确定单元可以产生具有两个不同频率（优选低于100kHz）的测量电流，并且分析单元可以计算针对测量电流的不同频率按时间顺序分配给彼此的阻抗或导纳值对，并且计算 血液阻抗或血液导入分量的值，其独立于围绕特定血管的身体组织的阻抗。分析单元还可以确定该值随时间的趋势作为血液血细胞比容值变化的指标。

公开(公告)号：US08571641B2

公开(公告)日：2013-10-29

申请号：US12757307

申请日：2010-04-09

申请人： Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl ,  Gerald Czygan ,  Stefan Paule

发明人： Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/04

CPC分类号： A61B5/0537 ,  A61B5/0031 ,  A61B5/1116 ,  A61B5/4869 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/686 ,  A61B2562/0219 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3655 ,  A61N1/36564 ,  A61N1/36571

摘要： A monitoring apparatus having a signal input for signals representing measurement values of one or more physiological parameters, and an evaluation and processing unit connected to the signal input. The evaluation and processing unit is designed to select, or differently weight, individual values from the values received for further processing based on one or more criteria such that measurement values raising doubts as to the validity thereof are not selected or given a very low weighting.

摘要翻译： 一种具有用于表示一个或多个生理参数的测量值的信号的信号输入的监视装置，以及连接到所述信号输入的评估和处理单元。 评估和处理单元被设计为基于一个或多个标准从接收到的值中选择或不同地权重的值，以使得对其有效性产生怀疑的测量值不被选择或给出非常低的加权。

公开(公告)号：US07844335B2

公开(公告)日：2010-11-30

申请号：US12061796

申请日：2008-04-03

申请人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

发明人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/37 ,  A61N1/37241 ,  A61N2001/0585

摘要： A device is connected to electrode leads which performs intracardiac impedance measurements, conducts a transient pacing protocol, analyses the impedance measurements, and generates an LV lead position quality factor. The transient pacing protocol includes a repeated change (“transitions”) between ventricular intrinsic rhythm and biventricular paced rhythm and may also include a variation of the atrioventricular delay (AVD) and/or the interventricular delay (VVD). The quality factor expresses the degree to which hemodynamic properties have improved due to BiV stimulation for the current LV lead position compared to intrinsic ventricular rhythm.

摘要翻译： 器件连接到执行心内阻抗测量的电极引线，执行瞬态起搏协议，分析阻抗测量值，并产生LV引线位置品质因数。 瞬时起搏方案包括心室内心节律与双心室起搏节律之间的重复变化（“转变”），还可包括房室延迟（AVD）和/或心室间延迟（VVD）的变化。 质量因子表现出与本征心室节律相比，由于针对当前LV引导位置的BiV刺激，血液动力学特性得到改善的程度。