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公开(公告)号：US20050214162A1
公开(公告)日：2005-09-29
申请号：US10511471
申请日：2003-04-23
申请人： Michael Muller , Christian Oehr , Heinrich Malthaner , Hermann Goehl , Reinhold Deppisch , Markus Storr
发明人： Michael Muller , Christian Oehr , Heinrich Malthaner , Hermann Goehl , Reinhold Deppisch , Markus Storr
CPC分类号： B01D67/009 , A61M1/3475 , A61M1/3486 , B01D67/0093 , B01D69/02 , B01J20/28004 , B01J20/28014 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28078 , B01J20/2808 , B01J20/28097 , B01J20/3242 , G01N33/6878 , G01N33/6881
摘要： A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.
摘要翻译： 公开了一种制备具有区域选择性亲和力的微孔亲和膜的方法，所述微孔亲和膜还包括在血液或所述流体纯化期间除去的血液或其它生物活性流体中的化合物，以及由所述方法生产的微孔亲和膜， 这样的微孔亲和膜，以及这种微孔亲和膜的使用。
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公开(公告)号：US07591948B2
公开(公告)日：2009-09-22
申请号：US10511471
申请日：2003-04-23
申请人： Michael Müller , Christian Oehr , Heinrich Malthaner , Hermann Goehl , Reinhold Deppisch , Markus Storr
发明人： Michael Müller , Christian Oehr , Heinrich Malthaner , Hermann Goehl , Reinhold Deppisch , Markus Storr
CPC分类号： B01D67/009 , A61M1/3475 , A61M1/3486 , B01D67/0093 , B01D69/02 , B01J20/28004 , B01J20/28014 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28078 , B01J20/2808 , B01J20/28097 , B01J20/3242 , G01N33/6878 , G01N33/6881
摘要： A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.
摘要翻译： 公开了一种制备具有区域选择性亲和力的微孔亲和膜的方法，所述微孔亲和膜还包括在血液或所述流体纯化期间除去的血液或其它生物活性流体中的化合物，以及由所述方法生产的微孔亲和膜， 这样的微孔亲和膜，以及这种微孔亲和膜的使用。
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公开(公告)号：US07875183B2
公开(公告)日：2011-01-25
申请号：US11599849
申请日：2006-11-15
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/34 , A61M1/3406 , A61M2205/3334 , B01D69/08 , B01D69/12 , B01D2325/02
摘要： There is provided a method of reducing blood free light chain concentration in a subject, the method comprising the step of subjecting the subject's blood to haemodialysis, haemodiafiltration or haemofiltration. There is also provided the use of a dialysis membrane which is a membrane that allows passage of molecules having a molecular weight of up to 45 kDa in presence of whole blood, and has a molecular weight exclusion limit in water of about 200 kDa in the preparation of a haemodialysis unit for conducting haemodialysis, haemodiafiltration or haemofiltration on a subject to reduce blood free light chain concentration in the patient.
摘要翻译： 本发明提供减少受试者血液中无血液轻链浓度的方法，该方法包括使受试者的血液进行血液透析，血液透析或血液透析的步骤。 还提供了透析膜的使用，该透析膜是允许在全血存在下具有高达45kDa分子量的分子通过的膜，并且在制剂中具有约200kDa水分子排阻极限 的血液透析单元，用于对受试者进行血液透析，血液透析过滤或血液过滤，以减少患者中的血液轻链浓度。
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公开(公告)号：US11478757B2
公开(公告)日：2022-10-25
申请号：US13578161
申请日：2011-04-13
申请人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
发明人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
摘要： A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.
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公开(公告)号：US08748538B2
公开(公告)日：2014-06-10
申请号：US13583827
申请日：2011-03-09
申请人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
发明人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
IPC分类号： B01D71/68 , C08F271/02
CPC分类号： C08F271/02 , B01D67/0011 , B01D67/0016 , B01D71/44 , B01D71/68 , B01D71/78 , B01D2323/08 , B01D2323/38 , C08G81/024 , C08L39/06 , C08L81/06 , C08L2666/04
摘要： Graft copolymers of hydrophobic polymers and hydrophilic polymers, a method for their preparation, and their use in membranes for medical treatments such as hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and in membranes for bioprocessing.
摘要翻译： 疏水性聚合物和亲水性聚合物的接枝共聚物，其制备方法以及它们用于医疗处理如血液透析，血液透析滤过和血液滤过的膜，用于水净化的膜和用于生物处理的膜中的用途。
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公开(公告)号：US20120305486A1
公开(公告)日：2012-12-06
申请号：US13578161
申请日：2011-04-13
申请人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
发明人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
CPC分类号： B01D67/0009 , A61M1/16 , A61M1/1696 , A61M2210/1071 , B01D69/08 , B01D69/087 , B01D71/68 , B01D2325/20
摘要： A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.
摘要翻译： 用于肝透析的系统使用高截止血液透析膜来从需要的人的血液中除去水溶性和蛋白质结合的毒素。 高截止的中空纤维血液透析膜具有改善去除白蛋白结合毒素和炎性介质的潜力。
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公开(公告)号：US20130137784A1
公开(公告)日：2013-05-30
申请号：US13583827
申请日：2011-03-09
申请人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
发明人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
IPC分类号： C08F271/02
CPC分类号： C08F271/02 , B01D67/0011 , B01D67/0016 , B01D71/44 , B01D71/68 , B01D71/78 , B01D2323/08 , B01D2323/38 , C08G81/024 , C08L39/06 , C08L81/06 , C08L2666/04
摘要： Graft copolymers of hydrophobic polymers and hydrophilic polymers, a method for their preparation, and their use in membranes for medical treatments such as hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and in membranes for bioprocessing.
摘要翻译： 疏水性聚合物和亲水性聚合物的接枝共聚物，其制备方法以及它们用于医疗处理如血液透析，血液透析滤过和血液滤过的膜，用于水净化的膜和用于生物处理的膜中的用途。
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公开(公告)号：US20070251882A1
公开(公告)日：2007-11-01
申请号：US11599849
申请日：2006-11-15
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/34 , A61M1/3406 , A61M2205/3334 , B01D69/08 , B01D69/12 , B01D2325/02
摘要： There is provided a method of reducing blood free light chain concentration in a subject, the method comprising the step of subjecting the subject's blood to haemodialysis, haemodiafiltration or haemofiltration. There is also provided the use of a dialysis membrane which is a membrane that allows passage of molecules having a molecular weight of up to 45 kDa in presence of whole blood, and has a molecular weight exclusion limit in water of about 200 kDa in the preparation of a haemodialysis unit for conducting haemodialysis, haemodiafiltration or haemofiltration on a subject to reduce blood free light chain concentration in the patient.
摘要翻译： 本发明提供减少受试者血液中无血液轻链浓度的方法，该方法包括使受试者的血液进行血液透析，血液透析或血液透析的步骤。 还提供了透析膜的使用，该透析膜是允许在全血存在下具有高达45kDa分子量的分子通过的膜，并且在制剂中具有约200kDa水分子排阻极限 的血液透析单元，用于对受试者进行血液透析，血液透析过滤或血液过滤，以减少患者中的血液轻链浓度。
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公开(公告)号：US20090008310A1
公开(公告)日：2009-01-08
申请号：US10595546
申请日：2004-11-05
申请人： Jurgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet , Francesco Ribolzi , Bjorn Frederik Seidler , Lennart Jonsson , Eddie Nilsson
发明人： Jurgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet , Francesco Ribolzi , Bjorn Frederik Seidler , Lennart Jonsson , Eddie Nilsson
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.
摘要翻译： 集成血液处理模块包括具有壳体（2）和第一端盖（4）的血液处理装置（1）和封闭壳体（2）的两端的第二端盖（5）。 用于蠕动泵的泵管（17）具有固定到壳体（2）的第一端（18）和连接到第一端盖（16）的血液入口（15）的第二端（16） （4）以形成环路。 脱气装置（30）连接到第二端帽（5）。 在使用中充满液体的脱气装置（30）包括疏水膜，气泡和微气泡通过该疏水膜逸出脱气装置。
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公开(公告)号：US07790029B2
公开(公告)日：2010-09-07
申请号：US10708774
申请日：2004-03-24
CPC分类号： B01D63/04 , B01D61/145 , B01D61/243 , B01D61/30 , B01D61/58 , B01D63/02 , B01D65/00 , Y10T29/49613
摘要： A filter device having filter means, in particular hollow fiber membranes, arranged in more than one filtration compartment within a filter housing. The filter device thereby allows more than one filtration process to be carried out serially and/or simultaneously within a single housing. For example a dialysis type filtration process such as hemofiltration or hemodiafiltration or hemodialysis may be carried out at the same time as an ultrafiltration process or as another hemofiltration, hemodiafiltration or hemodialysis process. The device may have a split shell construction bonded or welded together along longitudinal seams. Internal separating walls within the housing are formed integrally with the shell portions of the housing to form adjacent filtration compartments when the housing portions are joined together.
摘要翻译： 具有过滤器装置，特别是中空纤维膜的过滤装置，其布置在过滤器壳体内的多于一个过滤隔室中。 因此，过滤装置允许在单个壳体内串联和/或同时进行多于一个的过滤过程。 例如，透析型过滤方法如血液滤过或血液透析过滤或血液透析可以在超滤方法的同时进行，或作为另一种血液透析，血液透析过滤或血液透析过程进行。 该装置可以具有沿纵向接缝焊接或焊接在一起的分裂壳结构。 当壳体部分接合在一起时，壳体内部的分隔壁与壳体的壳体部分形成一体，以形成相邻的过滤隔室。
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