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    Filtration Membrane
    5.
    发明申请
    Filtration Membrane 审中-公开
    过滤膜

    公开(公告)号：US20090057225A1

    公开(公告)日：2009-03-05

    申请号：US11887957

    申请日：2006-04-06

    申请人： Bernd Krause ,  Markus Hornung ,  Thomas Ertl ,  Markus Storr

    发明人： Bernd Krause ,  Markus Hornung ,  Thomas Ertl ,  Markus Storr

    IPC分类号： B01D71/68 ,  B01D67/00 ,  C08G75/00

    CPC分类号： B01D71/44 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D69/087 ,  B01D69/12 ,  B01D71/52 ,  B01D71/60 ,  B01D71/68 ,  B01D71/82 ,  B01D2325/02 ,  B01D2325/026 ,  B01D2325/12 ,  B01D2325/16 ,  B01D2325/42

    摘要： The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges. The method of manufacturing such a ultrafiltration membrane comprises dissolving at least one hydrophobic polymer containing sulfur in its back bone and at least one hydrophilic, uncharged polyvinylpyrrolidone and at least one polymer containing cationic charges in at least one solvent to form a polymer solution, subjecting the formed polymer solution to a diffusion-induced phase separation to prepare a ultrafiltration membrane, washing and subsequently drying of the ultrafiltration membrane.

    摘要翻译： 本发明涉及能够从流体和/或液体介质中保留包含细菌DNA和/或DNA片段的内毒素和细胞因子诱导物质（CIS）的超滤膜。 本发明进一步涉及以高质量和有效且节省时间的方法制造这种超滤膜的方法，以及使用这种膜来保持来自流体或液体的物质。 本发明的超滤膜由包含至少一种在其背骨中含有硫的疏水性聚合物，至少一种亲水的，不带电的聚乙烯吡咯烷酮的聚合物和至少一种含有阳离子电荷的聚合物组成的聚合物共混物构成。 制造这种超滤膜的方法包括将至少一种含有硫的疏水性聚合物溶解在其背骨中，并且至少一种亲水的，不带电的聚乙烯吡咯烷酮和至少一种含至少一种溶剂中的阳离子电荷的聚合物形成聚合物溶液， 形成的聚合物溶液进行扩散诱导的相分离以制备超滤膜，洗涤并随后干燥超滤膜。

    Method of removing antibody free light chains from blood
    6.
    发明授权
    Method of removing antibody free light chains from blood 有权
    从血液中清除抗体自由轻链的方法

    公开(公告)号：US07875183B2

    公开(公告)日：2011-01-25

    申请号：US11599849

    申请日：2006-11-15

    申请人： Arthur Randell Bradwell ,  Hermann Goehl ,  Markus Storr

    发明人： Arthur Randell Bradwell ,  Hermann Goehl ,  Markus Storr

    IPC分类号： B01D11/00 ,  B01D61/00 ,  C02F1/44 ,  A61M1/16 ,  A61M1/34

    CPC分类号： A61M1/16 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3406 ,  A61M2205/3334 ,  B01D69/08 ,  B01D69/12 ,  B01D2325/02

    摘要： There is provided a method of reducing blood free light chain concentration in a subject, the method comprising the step of subjecting the subject's blood to haemodialysis, haemodiafiltration or haemofiltration. There is also provided the use of a dialysis membrane which is a membrane that allows passage of molecules having a molecular weight of up to 45 kDa in presence of whole blood, and has a molecular weight exclusion limit in water of about 200 kDa in the preparation of a haemodialysis unit for conducting haemodialysis, haemodiafiltration or haemofiltration on a subject to reduce blood free light chain concentration in the patient.

    摘要翻译： 本发明提供减少受试者血液中无血液轻链浓度的方法，该方法包括使受试者的血液进行血液透析，血液透析或血液透析的步骤。 还提供了透析膜的使用，该透析膜是允许在全血存在下具有高达45kDa分子量的分子通过的膜，并且在制剂中具有约200kDa水分子排阻极限 的血液透析单元，用于对受试者进行血液透析，血液透析过滤或血液过滤，以减少患者中的血液轻链浓度。

    Method of removing antibody free light chains from blood
    8.
    发明申请
    Method of removing antibody free light chains from blood 有权
    从血液中清除抗体自由轻链的方法

    公开(公告)号：US20070251882A1

    公开(公告)日：2007-11-01

    申请号：US11599849

    申请日：2006-11-15

    申请人： Arthur Randell Bradwell ,  Hermann Goehl ,  Markus Storr

    发明人： Arthur Randell Bradwell ,  Hermann Goehl ,  Markus Storr

    IPC分类号： B01D17/12 ,  B01D15/08

    CPC分类号： A61M1/16 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3406 ,  A61M2205/3334 ,  B01D69/08 ,  B01D69/12 ,  B01D2325/02

    摘要： There is provided a method of reducing blood free light chain concentration in a subject, the method comprising the step of subjecting the subject's blood to haemodialysis, haemodiafiltration or haemofiltration. There is also provided the use of a dialysis membrane which is a membrane that allows passage of molecules having a molecular weight of up to 45 kDa in presence of whole blood, and has a molecular weight exclusion limit in water of about 200 kDa in the preparation of a haemodialysis unit for conducting haemodialysis, haemodiafiltration or haemofiltration on a subject to reduce blood free light chain concentration in the patient.

    摘要翻译： 本发明提供减少受试者血液中无血液轻链浓度的方法，该方法包括使受试者的血液进行血液透析，血液透析或血液透析的步骤。 还提供了透析膜的使用，该透析膜是允许在全血存在下具有高达45kDa分子量的分子通过的膜，并且在制剂中具有约200kDa水分子排阻极限 的血液透析单元，用于对受试者进行血液透析，血液透析过滤或血液过滤，以减少患者中的血液轻链浓度。

    ENZYME-FUNCTIONALIZED SUPPORTS
    10.
    发明申请
    ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
    酶功能化支持

    公开(公告)号：US20120208256A1

    公开(公告)日：2012-08-16

    申请号：US13503204

    申请日：2010-10-20

    申请人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    发明人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    IPC分类号： C12N11/06 ,  C12N11/02

    CPC分类号： C12N9/18 ,  C09D133/14 ,  C12N9/80 ,  C12N11/06 ,  C12N11/08

    摘要： An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.

    摘要翻译： 固定化酶包括固体支持物，与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。 制备固定化酶的方法包括：提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。 可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团，以在载体的表面上形成聚合物链。 如果聚合物链不包括伯氨基官能团，则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。 该方法还包括将酶偶联到聚合物链的氨基官能团。