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    MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells
    6.
    发明授权
    MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells 有权
    MIR-200家族在卵巢癌细胞中诱导间充质转化（MET）

    公开(公告)号：US08895509B2

    公开(公告)日：2014-11-25

    申请号：US13989312

    申请日：2011-11-23

    申请人： John McDonald ,  Nathan John Bowen ,  LiJuan Wang

    发明人： John McDonald ,  Nathan John Bowen ,  LiJuan Wang

    IPC分类号： A61K48/00 ,  A61K9/51 ,  A61K45/06 ,  A61K31/713 ,  A61K31/7105 ,  C12N15/113 ,  A61K9/00

    CPC分类号： C12N15/1135 ,  A61K9/00 ,  A61K9/51 ,  A61K9/5138 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31

    摘要： The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).

    摘要翻译： 本发明提供了一种治疗卵巢癌的方法，所述方法包括以有效治疗卵巢癌的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。 还提供了预防卵巢癌转移的方法，所述方法包括以有效预防转移的量将一种或多种miR-200家族成员递送至有需要的哺乳动物受试者。 还提供了使卵巢癌对细胞毒性疗法敏感的方法，该方法包括以有效使卵巢癌对细胞毒性疗法敏感的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。 本发明还考虑了在卵巢癌或癌细胞中减少上皮 - 间质转化（EMT）的方法以及诱导间充质 - 上皮转换（MET）的方法。

    MIR-200 FAMILY INDUCES MESENCHYMAL-TO-EPITHELIAL TRANSITION (MET) IN OVARIAN CANCER CELLS
    8.
    发明申请
    MIR-200 FAMILY INDUCES MESENCHYMAL-TO-EPITHELIAL TRANSITION (MET) IN OVARIAN CANCER CELLS 有权
    MIR-200家族在OVARIAN癌细胞中诱导MESENCHYMAL-E上皮转移（MET）

    公开(公告)号：US20130243876A1

    公开(公告)日：2013-09-19

    申请号：US13989312

    申请日：2011-11-23

    申请人： John McDonald ,  Nathan John Bowen ,  LiJuan Wang

    发明人： John McDonald ,  Nathan John Bowen ,  LiJuan Wang

    IPC分类号： A61K31/7105 ,  A61K9/51 ,  A61K45/06

    CPC分类号： C12N15/1135 ,  A61K9/00 ,  A61K9/51 ,  A61K9/5138 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31

    摘要： The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).

    摘要翻译： 本发明提供了一种治疗卵巢癌的方法，所述方法包括以有效治疗卵巢癌的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。 还提供了预防卵巢癌转移的方法，所述方法包括以有效预防转移的量将一种或多种miR-200家族成员递送至有需要的哺乳动物受试者。 还提供了使卵巢癌对细胞毒性疗法敏感的方法，该方法包括以有效使卵巢癌对细胞毒性疗法敏感的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。 本发明还考虑了在卵巢癌或癌细胞中减少上皮 - 间质转化（EMT）的方法以及诱导间充质 - 上皮转换（MET）的方法。

    Suspension packaging system
    9.
    发明授权
    Suspension packaging system 有权
    悬挂包装系统

    公开(公告)号：US08499937B2

    公开(公告)日：2013-08-06

    申请号：US13472394

    申请日：2012-05-15

    申请人： John McDonald ,  Frank Comerford ,  Myles Comerford

    发明人： John McDonald ,  Frank Comerford ,  Myles Comerford

    IPC分类号： B65D81/02

    CPC分类号： B65D81/07 ,  B65D5/5021 ,  B65D5/5028

    摘要： A suspension packaging system can include a foldable member configured to form a cavity as well as a suspension device for suspending an article to be packaged within the cavity. The suspension portion can include foldable portions configured to cooperate with a retention member having pockets. The foldable portions can fit into the pockets and then be folded so as to generate tension in the retention member. The entire device, with the exception of the retention member, can be made from a single piece of material, such as corrugated cardboard, which thus reduces waste and simplifies bulk distribution of such a suspension packaging system.

    摘要翻译： 悬挂包装系统可以包括构造成形成空腔的可折叠构件以及用于悬挂待包装物品在空腔内的悬挂装置。 悬挂部分可以包括被配置为与具有口袋的保持构件配合的可折叠部分。 可折叠部分可以装配到袋中，然后被折叠以便在保持构件中产生张力。 除了保持构件之外，整个装置可以由单件材料制成，例如瓦楞纸板，从而减少浪费并简化这种悬挂包装系统的散装。

    ELEVATED TOOL HOLDER
    10.
    发明申请
    ELEVATED TOOL HOLDER 审中-公开
    高级工具夹

    公开(公告)号：US20130180938A1

    公开(公告)日：2013-07-18

    申请号：US13741006

    申请日：2013-01-14

    申请人： John McDonald

    发明人： John McDonald

    IPC分类号： A47B81/00 ,  A47G21/14

    CPC分类号： A47B81/00 ,  A47G21/14 ,  B25H1/12 ,  B25H3/00

    摘要： An elevated tool holder system includes a storage block that is raised from the surface on which it is placed and has a storage area underneath the storage block to accommodate the storage of other items. The elevated tool holder can be placed inside a drawer to enable the drawer to be used for safe storage of tools as well as storage of other items.

    摘要翻译： 升高的工具架系统包括从其放置的表面上升起的存储块，并且在存储块下方具有容纳其它物品的存储的存储区域。 升高的工具架可以放置在抽屉内，以使抽屉可用于安全存放工具以及储存其他物品。