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公开(公告)号：US10653757B2
公开(公告)日：2020-05-19
申请号：US14234269
申请日：2012-07-20
申请人： Michael R. Yeaman , John E. Edwards, Jr. , Scott G. Filler , Ashraf S. Ibrahim , Yue Fu , John P. Hennessey, Jr.
发明人： Michael R. Yeaman , John E. Edwards, Jr. , Scott G. Filler , Ashraf S. Ibrahim , Yue Fu , John P. Hennessey, Jr.
摘要： The invention features a method of vaccinating a mammal against Staphylococcus aureus which includes the steps of: a) identifying a mammal at risk for the development of a Staphylococcus aureus skin or soft tissue infection; and b) administering to said mammal an immunogenic amount of a vaccine that includes a polypeptide including an isolated agglutinin-like sequence (Als) 3 protein (Als3p), or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
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公开(公告)号：US20150273031A1
公开(公告)日：2015-10-01
申请号：US14234269
申请日：2012-07-20
申请人： Michael R. Yeaman , John E. Edwards, JR. , Scott G. Filler , Ashraf S. Ibrahim , Yue Fu , John P. Hennessey, JR.
发明人： Michael R. Yeaman , John E. Edwards, JR. , Scott G. Filler , Ashraf S. Ibrahim , Yue Fu , John P. Hennessey, JR.
CPC分类号： A61K39/0002 , A61K45/06 , A61K2039/55505 , A61K2039/58
摘要： The invention features a method of vaccinating a mammal against Staphylococcus aureus which includes the steps of: a) identifying a mammal at risk for the development of a Staphylococcus aureus skin or soft tissue infection; and b) administering to said mammal an immunogenic amount of a vaccine that includes a polypeptide including an isolated agglutinin-like sequence (Als) 3 protein (Als3p), or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译： 本发明的特征在于一种针对金黄色葡萄球菌接种哺乳动物的方法，其包括以下步骤：a）鉴定处于发生金黄色葡萄球菌皮肤或软组织感染风险的哺乳动物; 和b）向所述哺乳动物施用免疫原性量的疫苗，其包含在药学上可接受的培养基中包含分离的凝集素样序列（Als）3蛋白（Als3p）或其免疫原性片段的多肽。
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3.发明申请PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开药物组合物和抗肿瘤药物和其他感染性药物的方法公开(公告)号：US20140037689A1
公开(公告)日：2014-02-06
申请号：US13785835
申请日：2013-03-05
申请人： John E. Edwards, JR. , Ashraf S. Ibrahim , Brad J. Spellberg , Yue Fu , Scott G. Filler , Michael R. Yeaman
发明人： John E. Edwards, JR. , Ashraf S. Ibrahim , Brad J. Spellberg , Yue Fu , Scott G. Filler , Michael R. Yeaman
IPC分类号： A61K39/00
CPC分类号： A61K39/0002 , A61K39/085 , A61K2039/5156 , A61K2039/58 , C07K16/14 , C07K2317/76
摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections.
摘要翻译： 本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。 本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。 还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。 还提供了治疗或预防金黄色葡萄球菌感染的方法。
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4.发明授权Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis 失效用于接种传播性念珠菌病的药物组合物和方法公开(公告)号：US07067138B1
公开(公告)日：2006-06-27
申请号：US09715876
申请日：2000-11-18
申请人： John E. Edwards, Jr. , Scott G. Filler , Donald C. Sheppard , Ashraf S. Ibrahim , Yue Fu , Bradley J. Spellberg
发明人： John E. Edwards, Jr. , Scott G. Filler , Donald C. Sheppard , Ashraf S. Ibrahim , Yue Fu , Bradley J. Spellberg
CPC分类号： C07K16/14 , A61K39/0002 , A61K2039/505 , A61K2039/53 , Y10S530/806 , Y10S530/824
摘要： A Candida albicans bloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors of C. albicans. Multiple filamentation regulatory pathways have been discovered, however the downstream effectors of these regulatory pathways remain unknown. The cell surface protein, Als1p, is a downstream effector of the filamentation regulatory pathway and is regulated by Efg1p. Als1p mediates adherence to endothelial cells in vitro and is required for virulence. The blocking of adherence by the organism is described resulting from the use of a composition and method disclosed herein. Specifically, a pharmaceutical composition comprised of a gene product from the ALS1 gene family is administered as a vaccine to generate an immune response capable of blocking adherence of the organism.
摘要翻译： 白色念珠菌血液感染在住院患者中引起显着的发病率和死亡率。 丝状体形成和粘附宿主细胞是白色念珠菌的关键毒力因子。 已经发现多个丝状调节途径，但是这些调节途径的下游作用因素仍然未知。 细胞表面蛋白Als1p是丝状细胞调节通路的下游效应物，受Efg1p调控。 Als1p在体外介导对内皮细胞的依从性，是毒力所必需的。 使用本文公开的组合物和方法描述了由有机体粘附的阻断。 特别地，作为疫苗施用由ALS1基因家族的基因产物组成的药物组合物，以产生能够阻断生物的粘附的免疫应答。
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公开(公告)号：US08541008B2
公开(公告)日：2013-09-24
申请号：US10245802
申请日：2002-09-13
申请人： John E. Edwards, Jr. , Scott G. Filler , Donald C. Sheppard , Ashraf S. Ibrahim , Yue Fu , Bradley J. Spellberg
发明人： John E. Edwards, Jr. , Scott G. Filler , Donald C. Sheppard , Ashraf S. Ibrahim , Yue Fu , Bradley J. Spellberg
CPC分类号： A61K39/39575 , A61K38/16 , A61K39/0002 , A61K45/06 , A61K2039/505 , A61K2039/53 , C07K14/40 , C07K16/14
摘要： A Candida albicans bloodstream infections cause significant morbidity and mortality in hospitalized patients. Filament formation and adherence to host cells are critical virulence factors of C. albicans. Multiple filamentation regulatory pathways have been discovered, however the downstream effectors of these regulatory pathways remain unknown. The cell surface proteins in the ALS group are downstream effectors of the filamentation regulatory pathway. Particularly, Als1p mediates adherence to endothelial cells in vitro and is required for virulence. The blocking of adherence by the organism is described resulting from the use of a composition and method disclosed herein. Specifically, a pharmaceutical composition comprised of a gene, gene product, or specific antibody to the ALS gene family is administered as a vaccine to generate an immune response capable of blocking adherence of the organism.
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公开(公告)号：US10160790B2
公开(公告)日：2018-12-25
申请号：US14344838
申请日：2012-09-14
摘要： The disclosure features isolated polypeptides of Hyr1. The disclosure further features vaccines and antibodies useful in treating or preventing candidiasis or Acinetobacter infections or both. Further disclosed are isolated polypeptides consisting of between 14 and 20 amino acids for vaccine preparation. The specific amino acid sequences of isolated polypeptides of Hyr1 are also disclosed.
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公开(公告)号：US20150191514A1
公开(公告)日：2015-07-09
申请号：US14344838
申请日：2012-09-14
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , A61K47/646 , A61K2039/6081 , C07K16/14
摘要： The disclosure features isolated polypeptides of Hyr1. The disclosure further features vaccines and antibodies useful in treating or preventing candidiasis or Acinetobacter infections or both. Further disclosed are isolated polypeptides consisting of between 14 and 20 amino acids for vaccine preparation. The specific amino acid sequences of isolated polypeptides of Hyr1 are also disclosed.
摘要翻译： 该公开的特征是Hyr1的分离的多肽。 本公开进一步具有用于治疗或预防念珠菌病或不动杆菌感染或两者的疫苗和抗体。 进一步公开的是用于疫苗制备的由14个和20个氨基酸组成的分离的多肽。 还公开了Hyr1的分离的多肽的特定氨基酸序列。
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8.发明授权公开(公告)号：US08790662B2
公开(公告)日：2014-07-29
申请号：US13418263
申请日：2012-03-12
CPC分类号： C12N5/0694 , A61K2035/124 , C12N5/0642 , C12N2500/30 , C12N2500/44 , C12N2500/62 , C12N2501/385
摘要： The invention is based, in part, on the discovery of a novel cell-based immunotherapy that can recapitulate neutrophil functions in neutropenic individuals afflicted with a microbial infection. The therapeutic methods of the invention are broadly applicable to treat any infection in a neutropenic individual, including infections caused by bacteria, fungi, protozoa, and viruses. The methods of the invention represent a practical, rapid cell-based immunotherapy for refractory infections comprising compositions of activated, irradiated HL-60 cells.
摘要翻译： 本发明部分地基于发现一种新的基于细胞的免疫疗法，其可以概括地患有微生物感染的中性粒细胞减少的个体中的嗜中性粒细胞功能。 本发明的治疗方法广泛适用于治疗嗜中性粒细胞减少个体的任何感染，包括由细菌，真菌，原生动物和病毒引起的感染。 本发明的方法代表了用于难治性感染的实用的基于细胞的快速免疫治疗，其包含活化的照射的HL-60细胞的组合物。
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公开(公告)号：US09279002B2
公开(公告)日：2016-03-08
申请号：US13620563
申请日：2012-09-14
申请人： Ashraf S. Ibrahim , Mingfu Liu , Teklegiorgis Ghebremariam , Yue Fu , John E. Edwards , Scott Filler
发明人： Ashraf S. Ibrahim , Mingfu Liu , Teklegiorgis Ghebremariam , Yue Fu , John E. Edwards , Scott Filler
CPC分类号： C07K16/14 , A61K2039/505 , C07K14/37 , C07K2317/24 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/56961 , G01N2333/37 , G01N2469/10
摘要： The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.
摘要翻译： 本发明提供了Mucorales CotH多肽并编码核酸分子。 Mucorales CotH多肽和编码核酸可有利地用于诊断，治疗或预防真菌病症，特别是毛霉菌病。
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10.发明申请Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases 有权疫苗组合物和治疗毛霉菌病及其他真菌病的方法公开(公告)号：US20100285024A1
公开(公告)日：2010-11-11
申请号：US12661609
申请日：2010-03-19
申请人： Ashraf S. Ibrahim , Brad J. Spellberg , Yue Fu , John E. Edwards
发明人： Ashraf S. Ibrahim , Brad J. Spellberg , Yue Fu , John E. Edwards
IPC分类号： A61K39/395 , A61K39/00 , A61K31/7052 , A61K38/43 , A61P37/04 , A61P31/10
CPC分类号： C07K16/14 , A61K2039/505 , C12N9/00 , C12N15/1138 , C12N2310/14
摘要： The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.
摘要翻译： 本发明提供治疗和预防真菌病或包括毛霉菌病的病症的治疗组合物和方法。 本发明的治疗方法和组合物包括具有多肽的FTR多肽或抗原性片段的疫苗组合物; 包含与FTR序列的至少18个连续核苷酸基本互补的核苷酸序列的载体; 反义词 小干扰RNA或FTR的抗体抑制剂。 本发明的疫苗组合物还可包含佐剂。
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