公开(公告)号：US08499890B2

公开(公告)日：2013-08-06

申请号：US12688772

申请日：2010-01-15

申请人： Kevin R. Stone ,  Michael Strasser ,  Thomas King ,  Imraan Aziz

发明人： Kevin R. Stone ,  Michael Strasser ,  Thomas King ,  Imraan Aziz

IPC分类号： A62B1/10

CPC分类号： A62B1/10

摘要： A personal escape device which can be used by men, women, and children, including physically disabled persons, to descend in a controlled and secure manner from high structures such as office buildings, multistory homes, and the like. The device is designed for a relatively low-cost, small size which may be used by payloads of variable weights. The rescue device of the invention may be a single-use device or a multi-use device.

摘要翻译： 包括身体残疾人在内的男子，妇女和儿童使用的个人逃生装置，可以以受控和安全的方式从诸如办公楼，多层住宅等的高层建筑中下来。 该设备设计用于相对低成本，小尺寸，可由可变重量的有效载荷使用。 本发明的救援装置可以是一次性装置或多用途装置。

公开(公告)号：US20100065373A1

公开(公告)日：2010-03-18

申请号：US12218922

申请日：2008-07-18

申请人： Kevin R. Stone ,  Michael Strasser ,  Thomas King

发明人： Kevin R. Stone ,  Michael Strasser ,  Thomas King

IPC分类号： A62B1/12 ,  H04B1/38

CPC分类号： A62B1/10

摘要： The invention presents devices for controlled descent from buildings. Such a device includes a housing having a primary spool about which a cord is wound, a payload coupler for attaching a harness assembly to the housing, and an unwind control assembly for controlling the rate of exit of the cord from the housing. An inventive device kit may include a convertible storage unit used to protectively store a device and which, upon deployment, may be used as a protective helmet. In using an inventive device, a user attaches the device to a fixture in a building, dons a harness and the converted helmet, attaches the device to the harness, and exits the building from a window or roof.

摘要翻译： 本发明提出了用于从建筑物控制下降的装置。 这样的装置包括具有初级线轴的外壳，绕线缠绕在该主壳体上，用于将线束组件附接到壳体的有效负载耦合器，以及用于控制电线从壳体的退出速率的退绕控制组件。 本发明的设备套件可以包括用于保护性地存储设备的可转换存储单元，并且在部署时可以将其用作防护头盔。 在使用本发明的设备时，使用者将设备附接到建筑物中的固定装置，无用的线束和转换的头盔，将装置附接到线束，并从窗户或屋顶离开建筑物。

公开(公告)号：US08567561B2

公开(公告)日：2013-10-29

申请号：US12218922

申请日：2008-07-18

申请人： Michael Strasser ,  Thomas King ,  Kevin R. Stone

发明人： Michael Strasser ,  Thomas King ,  Kevin R. Stone

IPC分类号： A62B1/10

CPC分类号： A62B1/10

摘要： The invention presents devices for controlled descent from buildings. Such a device includes a housing having a primary spool about which a cord is wound, a payload coupler for attaching a harness assembly to the housing, and an unwind control assembly for controlling the rate of exit of the cord from the housing. An inventive device kit may include a convertible storage unit used to protectively store a device and which, upon deployment, may be used as a protective helmet. In using an inventive device, a user attaches the device to a fixture in a building, dons a harness and the converted helmet, attaches the device to the harness, and exits the building from a window or roof.

摘要翻译： 本发明提出了用于从建筑物控制下降的装置。 这样的装置包括具有初级线轴的外壳，绕线缠绕在该主壳体上，用于将线束组件附接到壳体的有效负载耦合器，以及用于控制电线从壳体的退出速率的退绕控制组件。 本发明的设备套件可以包括用于保护性地存储设备的可转换存储单元，并且在部署时可以将其用作防护头盔。 在使用本发明的设备时，使用者将设备附接到建筑物中的固定装置，无用的线束和转换的头盔，将装置附接到线束，并从窗户或屋顶离开建筑物。

公开(公告)号：US20110104229A1

公开(公告)日：2011-05-05

申请号：US12909605

申请日：2010-10-21

申请人： Kevin R. Stone ,  Uri Galili

发明人： Kevin R. Stone ,  Uri Galili

IPC分类号： A61K9/00 ,  C12N5/077 ,  C12N13/00 ,  A61K35/12 ,  A61P19/00

CPC分类号： A61L27/3691 ,  A61F2/28 ,  A61F2/3094 ,  A61F2002/2835 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/3687 ,  A61L27/3847

摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft (X) for the implantation into a defect (D) located in a bone portion (10) of a human. The invention further provides methods for preparing a bone xenograft (X) by removing at least a portion of bone from a non-human animal to provide a xenograft (X); washing the xenograft (X) in saline and alcohol; and subjecting the xenograft (X) to at least one of the treatments including exposure to ultraviolet radiation, immersion in alcohol, ozonic, and freeze/thaw cycling. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment, and digestion of the carbohydrate moieties of the xenograft (X) with a glycosidase followed by treatment for sialylation.

摘要翻译： 本发明提供了一种制品，其包括用于植入到位于人的骨部分（10）中的缺陷（D）的基本上非免疫原性骨异种移植物（X）。 本发明还提供了通过从非人动物中去除至少一部分骨以提供异种移植物（X）来制备骨异种移植物（X）的方法; 用盐水和酒精清洗异种移植物（X）; 并将异种移植物（X）进行至少一种处理，包括暴露于紫外线辐射，浸入酒精，臭氧和冷冻/融化循环中。 除了上述处理之外或代替上述处理，所述方法包括细胞破碎处理和用糖苷酶消化异种移植物（X）的碳水化合物部分，接着进行唾液酸化处理。

公开(公告)号：US07645568B2

公开(公告)日：2010-01-12

申请号：US10914536

申请日：2004-08-09

申请人： Kevin R. Stone

发明人： Kevin R. Stone

IPC分类号： A01N1/02 ,  A61F2/24

CPC分类号： A61F2/28 ,  A01N1/00 ,  A61F2/08 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/38 ,  A61F2002/2817 ,  A61F2002/30677 ,  A61K35/34 ,  A61L27/3625 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/507 ,  A61L2430/40

摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic heart valve xenograft for implantation into humans. The invention further provides methods for preparing a heart valve xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; treating the xenograft with crosslinking agents, and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a heart valve xenograft for implantation into a human including a portion of a heart valve from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native heart valve.

摘要翻译： 本发明提供了一种包括用于植入人体的基本上非免疫原性心脏瓣膜异种移植物的制品。 本发明还提供了通过从非人动物中去除至少一部分软组织以提供异种移植物来制备心脏瓣膜异种移植物的方法; 用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 用交联剂处理异种移植物，并用蛋白多糖消耗因子和/或糖苷酶消化异种移植物。 本发明还提供了通过本发明的上述方法制造的制品。 本发明进一步提供用于植入人的心脏瓣膜异种移植物，其包括来自非人动物的心脏瓣膜的一部分，其中所述部分具有细胞外组分并且基本上仅仅是死细胞。 细胞外成分降低蛋白聚糖分子。 本发明的每种异种移植物基本上是非免疫原性的并且具有与相应的天然心脏瓣膜基本上相同的机械性质。

公开(公告)号：US06432929B1

公开(公告)日：2002-08-13

申请号：US09598634

申请日：2000-06-21

申请人： Kevin R. Stone

发明人： Kevin R. Stone

IPC分类号： A61K3170

CPC分类号： A23L2/02 ,  A23L2/52 ,  A23L7/101 ,  A23L7/122 ,  A23L7/126 ,  A23L33/10 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/726 ,  A61K31/728 ,  A61K31/737 ,  A61K45/06 ,  Y10S514/904 ,  Y10S514/905 ,  A23V2250/5106 ,  A23V2250/606 ,  A23V2250/54246 ,  A23V2250/30 ,  A23V2250/02 ,  A23V2250/1614 ,  A23V2250/61 ,  A23V2250/54252 ,  A23V2250/5488 ,  A23V2250/628 ,  A23V2250/154 ,  A23V2250/708 ,  A23V2250/21 ,  A23V2250/16 ,  A23V2250/2482 ,  A23V2250/032 ,  A23V2250/242

摘要： A food supplement, either in the form of a snack bar or a beverage, which contains one or more cartilage enhancing supplements is provided. The cartilage supplements include chondroitin, glucosamine, and hyaluronic acid. The food supplement may additionally be fortified with cetyl myristoleate. The beverage is a mixture of a juice drink base which may include a water-based fruit flavored juice prepared using a pasteurization process at a relatively high temperature and a cartilage supplement solution which includes a cartilage supplement prepared at a relatively low temperature. The beverage may be carbonated, non-carbonated or concentrated. The preferred cartilage supplement is glucosamine, preferably associated with a counter ion, more preferably as glucosamine HCl.

摘要翻译： 提供了包含一种或多种软骨增强补充剂的以小吃店或饮料形式的食品补充剂。 软骨补充剂包括软骨素，葡萄糖胺和透明质酸。 食物补充剂可另外用十六烷基肉豆蔻酸盐加强。 该饮料是果汁饮料基料的混合物，其可以包括使用比较高温度下的巴氏消毒法制备的水性果味调味汁和包含在较低温度下制备的软骨补充剂的软骨补充剂溶液。 饮料可以是碳酸化的，非碳酸的或浓缩的。 优选的软骨补充物是葡糖胺，优选与抗衡离子相关，更优选作为葡糖胺HCl。

公开(公告)号：US06402783B1

公开(公告)日：2002-06-11

申请号：US09605222

申请日：2000-06-28

申请人： Kevin R. Stone

发明人： Kevin R. Stone

IPC分类号： A61F208

CPC分类号： A61L27/3691 ,  A61F2/08 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3662 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2430/10 ,  A61L2430/40 ,  Y10S623/901

摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic ligament or tendon xenograft for implantation into humans. The invention further provides a method for preparing a ligament xenograft by removing at least a portion of an ligament from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally chemical crosslinking. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment and glycosidase digestion of carbohydrate moieties of the xenograft followed by treatment of carbohydrate moieties of the xenograft with capping molecules. The invention also provides articles of manufacture produced by one or more of the above-identified methods of the invention. The invention further provides a ligament xenograft for implantation into a human including a portion of a ligament from a non-human animal, wherein the portion includes extracellular components and substantially only dead cells. The extracellular components and dead cells have substantially no surface &agr;-galactosyl moieties and have capping molecules linked to at least a portion of surface carbohydrate moieties. Each of the xenografts of the invention is substantially non-immunogenic and has substantially the same mechanical properties as the respective native ligament.

摘要翻译： 本发明提供了一种包括用于植入人体的基本上非免疫原性的韧带或腱异种移植物的制品。 本发明还提供了一种通过从非人动物中去除至少一部分韧带以提供异种移植来制备韧带异种移植物的方法; 用盐水和酒精清洗异种移植物; 将异种移植物进行至少一种治疗，所述治疗选自紫外线照射，浸入酒精，臭氧化，冷冻/解冻循环和任选的化学交联。 除了或代替上述处理之外，所述方法包括异种移植物的碳水化合物部分的细胞破碎处理和糖苷酶消化，随后用封端分子处理异种移植物的碳水化合物部分。 本发明还提供了通过本发明的一种或多种上述方法生产的制品。 本发明还提供用于植入人的韧带异种移植物，其包括来自非人动物的韧带的一部分，其中所述部分包括细胞外组分和基本上只有死细胞。 细胞外组分和死细胞基本上没有表面α-半乳糖基部分，并且具有连接至表面碳水化合物部分的至少一部分的封端分子。 本发明的每种异种移植物基本上是非免疫原性的并且具有与各自的天然韧带基本相同的机械性能。

公开(公告)号：US06383732B1

公开(公告)日：2002-05-07

申请号：US09585509

申请日：2000-06-01

申请人： Kevin R. Stone

发明人： Kevin R. Stone

IPC分类号： A01N102

CPC分类号： A61F2/28 ,  A01N1/00 ,  A61F2/08 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/38 ,  A61F2002/2817 ,  A61F2002/30677 ,  A61K35/34 ,  A61L27/3625 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/507 ,  A61L2430/40

摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic heart valve xenograft for implantation into humans. The invention further provides methods for preparing a heart valve xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; treating the xenograft with crosslinking agents, and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a heart valve xenograft for implantation into a human including a portion of a heart valve from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native heart valve.

摘要翻译： 本发明提供了一种包括用于植入人体的基本上非免疫原性心脏瓣膜异种移植物的制品。 本发明还提供了通过从非人动物中去除至少一部分软组织以提供异种移植物来制备心脏瓣膜异种移植物的方法; 用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 用交联剂处理异种移植物，并用蛋白多糖消耗因子和/或糖苷酶消化异种移植物。 本发明还提供了通过本发明的上述方法制造的制品。 本发明进一步提供用于植入人的心脏瓣膜异种移植物，其包括来自非人动物的心脏瓣膜的一部分，其中所述部分具有细胞外组分并且基本上仅仅是死细胞。 细胞外成分降低蛋白聚糖分子。 本发明的每种异种移植物基本上是非免疫原性的并且具有与相应的天然心脏瓣膜基本上相同的机械性质。

公开(公告)号：US5865849A

公开(公告)日：1999-02-02

申请号：US483256

申请日：1995-06-07

申请人： Kevin R. Stone

发明人： Kevin R. Stone

IPC分类号： A61F2/28 ,  A61F2/30 ,  A61F2/38 ,  A61L27/36

CPC分类号： A61L27/3691 ,  A61F2/30756 ,  A61F2/3872 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3687 ,  A61F2/3094 ,  A61F2002/2835 ,  A61L2430/10

摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic knee meniscal heterografts for implantation into humans. The invention further provides a method for preparing a knee meniscal heterograft by removing at least a portion of a meniscus from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic meniscus.

公开(公告)号：US5702422A

公开(公告)日：1997-12-30

申请号：US567895

申请日：1995-12-06

申请人： Kevin R. Stone

发明人： Kevin R. Stone

IPC分类号： A61B17/04 ,  A61B17/11 ,  A61B17/00

CPC分类号： A61F2/0811 ,  A61B17/0401 ,  A61B17/1146 ,  A61B2017/0409 ,  A61F2002/0888 ,  Y10S606/916

摘要： The invention provides a method of repairing tears or ruptures in an anterior cruciate ligament of the human knee, by reattaching the ligament to its anatomic insertion site on the intercondylar notch of the femur using a suture anchor, with healing at the insertion site being enhanced by formation of a cancellous bleeding bed.

摘要翻译： 本发明提供了一种修复人膝关节前交叉韧带撕裂或破裂的方法，通过使用缝合锚将肌腱重新连接到股骨髁间隙上的解剖插入位置，在插入部位的愈合被增强 形成松质骨渗出床。