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公开(公告)号:US06117680A
公开(公告)日:2000-09-12
申请号:US140149
申请日:1998-08-26
IPC分类号: G01N33/50 , A61K38/00 , A61K48/00 , C07K14/035 , C07K14/075 , C07K14/39 , C07K14/47 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/67 , C12N15/63
CPC分类号: C12N15/67 , C07K14/005 , C07K14/39 , C07K14/4705 , C12N15/1055 , A61K38/00 , C07K2319/00 , C12N2710/16622
摘要: The present invention relates to novel fusion proteins which activate transcription, to nucleic acid constructs encoding the proteins and their use in the genetic engineering of cells.
摘要翻译: 本发明涉及激活转录的新型融合蛋白,编码蛋白的核酸构建体及其在细胞遗传工程中的应用。
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公开(公告)号:US06306649B1
公开(公告)日:2001-10-23
申请号:US08672213
申请日:1996-06-27
IPC分类号: C12N500
CPC分类号: C07K14/4702 , C07K14/005 , C07K2319/00 , C12N2710/16622
摘要: This invention provides novel materials and methods involving the heterologous expression of transcription factors which are useful for effecting transcription of target genes in genetically engineered cells or organisms containing them. Target gene constructs and other materials useful for practicing the invention are also disclosed.
摘要翻译: 本发明提供涉及转录因子的异源表达的新型材料和方法,其可用于在遗传工程化的细胞或含有它们的生物体中实现靶基因的转录。 还公开了靶基因构建体和其他可用于实施本发明的材料。
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公开(公告)号:US06479653B1
公开(公告)日:2002-11-12
申请号:US09615917
申请日:2000-07-13
IPC分类号: C07H2104
CPC分类号: C12N15/67 , A61K38/00 , C07K14/005 , C07K14/39 , C07K14/4705 , C07K2319/00 , C12N15/1055 , C12N2710/16622
摘要: The present invention relates to novel fusion proteins which activate transcription, to nucleic acid constructs encoding the proteins and their use in the genetic engineering of cells.
摘要翻译: 本发明涉及激活转录的新型融合蛋白,编码蛋白的核酸构建体及其在细胞遗传工程中的应用。
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4.
公开(公告)号:US6015709A
公开(公告)日:2000-01-18
申请号:US920610
申请日:1997-08-27
申请人: Sridaran Natesan
发明人: Sridaran Natesan
IPC分类号: A61K38/00 , C07K14/035 , C07K14/39 , C07K14/47 , C12N1/15 , C12N1/21 , C12N15/10 , C12N15/67 , C12N5/10 , C12N15/62
CPC分类号: C12N15/67 , C07K14/005 , C07K14/39 , C07K14/4705 , C12N15/1055 , A61K38/00 , C07K2319/00 , C12N2710/16622
摘要: The present invention relates to chimeric transcriptional activators.
摘要翻译: 本发明涉及嵌合转录激活因子。
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公开(公告)号:US20070280885A1
公开(公告)日:2007-12-06
申请号:US11568525
申请日:2005-05-04
申请人: Karen Chandross , Jean Merrill , Sridaran Natesan
发明人: Karen Chandross , Jean Merrill , Sridaran Natesan
CPC分类号: G01N33/6872 , C12Q1/485 , G01N33/6896 , G01N2333/71 , G01N2500/02
摘要: Methods of identifying and using compounds capable of treating demyelinating disorders such as multiple sclerosis by inhibiting EphB1-mediated cell repulsion of CNS and PNS glial cells (oligodendrocytes and Schwann cells and progenitor cells within these lineages).
摘要翻译: 鉴定和使用能够通过抑制CNS和PNS胶质细胞(这些谱系中的少突胶质细胞和雪旺氏细胞和祖细胞)的EphB1介导的细胞排斥来治疗脱髓鞘疾病如多发性硬化的化合物的方法。
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公开(公告)号:US08329669B2
公开(公告)日:2012-12-11
申请号:US12304818
申请日:2007-07-25
CPC分类号: A61K31/7105 , A61K9/0019 , A61K48/00 , C12N9/0055 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2799/027 , C12Y110/02002
摘要: The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.
摘要翻译: 本发明涉及一种可用于治疗肿瘤的组合物,该组合物的制备方法和使用该组合物的方法。 本发明还涉及用于测定线粒体呼吸复合物III的核心蛋白1和/或其它蛋白质的活性抑制剂的方法。
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公开(公告)号:US20100035807A1
公开(公告)日:2010-02-11
申请号:US12304818
申请日:2007-07-25
IPC分类号: A61K38/19 , A61K31/7088 , G01N33/53 , A61P35/00
CPC分类号: A61K31/7105 , A61K9/0019 , A61K48/00 , C12N9/0055 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2799/027 , C12Y110/02002
摘要: The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.
摘要翻译: 本发明涉及一种可用于治疗肿瘤的组合物,该组合物的制备方法和使用该组合物的方法。 本发明还涉及用于测定线粒体呼吸复合物III的核心蛋白1和/或其它蛋白质的活性抑制剂的方法。
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8.
公开(公告)号:US20090226894A1
公开(公告)日:2009-09-10
申请号:US11721103
申请日:2005-12-01
申请人: Dorre Grueneberg , Xi Huang , Sridaran Natesan , Paul August
发明人: Dorre Grueneberg , Xi Huang , Sridaran Natesan , Paul August
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要: The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleid acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译: 本发明涉及通过与对照相比测量特定遗传标记物的增加或减少来预测或监测患者对紫杉类家族分子的反应的新颖和有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白质水平并将其水平与对照或参考标记进行比较来预测监测患者对紫杉烷类分子的反应的试剂盒。
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公开(公告)号:US20090215876A1
公开(公告)日:2009-08-27
申请号:US12223836
申请日:2007-02-14
CPC分类号: G01N33/5011 , C12N9/1205 , C12Q1/37 , C12Q1/485 , C12Y207/11001 , C12Y301/02015
摘要: The invention features methods of identifying candidate therapeutic compounds for the treatment of proliferative disorder. The invention also features methods for treating a proliferative disorder.
摘要翻译: 本发明的特征在于鉴定用于治疗增殖性疾病的候选治疗化合物的方法。 本发明还涉及治疗增殖性疾病的方法。
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