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公开(公告)号:US06230051B1
公开(公告)日:2001-05-08
申请号:US08877153
申请日:1997-06-17
IPC分类号: A61N130
CPC分类号: A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15142 , A61B10/0045 , A61B17/205 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , A61N1/30 , A61N1/303
摘要: A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent. The microblades having a relatively sharp angled leading edge which transitions to a relatively gradually angled blade edge.
摘要翻译: 一种经皮剂递送或取样装置,包括具有多个微刀片的片材,用于刺穿皮肤以增加药剂的经皮通量。 微型刀片具有相对尖锐的前缘,其转变成相对逐渐倾斜的叶片边缘。
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公开(公告)号:US07059348B2
公开(公告)日:2006-06-13
申请号:US10438282
申请日:2003-05-13
申请人: Avtar S. Nat
发明人: Avtar S. Nat
IPC分类号: A61M7/00 , F16K11/20 , F16K31/145
CPC分类号: A61K9/0024 , A61K9/0009 , A61K9/703 , Y10T137/87249 , Y10T137/88062
摘要: An implantable drug delivery system has a housing, a collapsible reservoir, a microfabricated flow channel, and at least one magnet. The collapsible reservoir is disposed in the housing. The microfabricated flow channel is connected at one end to the collapsible reservoir and opens at an external surface of the housing. The magnet is disposed within the housing adjacent a membrane defining the flow channel and is movable in response to a magnetic force to deflect the membrane into the flow channel for inhibiting drug flow from the collapsible reservoir to the external surface of the housing, and for pumping drug flow from the collapsible reservoir to the external surface of the housing.
摘要翻译: 可植入药物递送系统具有壳体,可折叠储存器,微加料流动通道和至少一个磁体。 可折叠储存器设置在壳体中。 微制造的流动通道在一端连接到可折叠的储存器,并在壳体的外表面打开。 磁体设置在壳体内,邻近限定流动通道的膜,并且可响应于磁力而移动,以将膜偏转到流动通道中,以阻止药物从可收缩储存器流到壳体的外表面,并且用于泵送 药物从可折叠储存器流到外壳的外表面。
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公开(公告)号:US6091975A
公开(公告)日:2000-07-18
申请号:US053272
申请日:1998-04-01
CPC分类号: A61B5/14865 , A61B2010/008
摘要: An agent detecting device comprising a plate (6) having a plurality of microprotrusions (4) for piercing the skin of a patient. Each of the microprotrusions (4) having an electrode (14, 16 and 18) thereon for detecting the presence of an agent in the patient's interstitial fluid.
摘要翻译: 一种药剂检测装置,包括具有用于刺穿患者皮肤的多个微突起(4)的板(6)。 每个微突起物(4)上都有一个电极(14,16和18),用于检测患者组织液中药剂的存在。
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公开(公告)号:US07060048B1
公开(公告)日:2006-06-13
申请号:US09548984
申请日:2000-04-14
申请人: Avtar S. Nat , Stuart P. Hendry , Colin Sheldrake
发明人: Avtar S. Nat , Stuart P. Hendry , Colin Sheldrake
IPC分类号: A61M5/30
CPC分类号: A61M5/3015 , A61M5/3134 , A61M2005/2073 , A61M2005/3104
摘要: A needleless syringe device for accelerating particles into a target tissue of a vertebrate subject is provided. The syringe features an elongate, tubular duct having a lumen for delivering the particles towards the target tissue. The duct may have a constant cross-sectional area. The device further features a receptacle holding the particles and a gas discharge chamber upstream of the receptacle. On actuation the gas discharge chamber discharges pressurised gas having a maximum total pressure of about 10 bar or less. Methods of using the device for delivering particles to a target tissue are also provided.
摘要翻译: 提供了一种用于将颗粒加速到脊椎动物对象的目标组织中的无针注射器装置。 注射器具有细长的管状管道,其具有用于将颗粒递送到靶组织的内腔。 管道可以具有恒定的横截面面积。 该装置还具有容纳颗粒的容器和容器上游的气体排出室。 在致动时,气体放电室排出具有约10巴或更小的最大总压力的加压气体。 还提供了使用该装置将颗粒输送到靶组织的方法。
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公开(公告)号:US5540665A
公开(公告)日:1996-07-30
申请号:US189473
申请日:1994-01-31
申请人: Stanley A. Mercado , Mark M. McPhee , Avtar S. Nat , Su I. Yum , Scott A. Bura
发明人: Stanley A. Mercado , Mark M. McPhee , Avtar S. Nat , Su I. Yum , Scott A. Bura
CPC分类号: C06D5/10 , A61M5/14526 , C06D5/00
摘要: The present invention provides a gas generating engine for driving a beneficial agent dispensing device. The engine comprising (a) a solid composition comprising an acidic compound or a basic compound, or a combination thereof, and (b) a means for maintaining substantially constant the surface area of the solid composition exposed to a reservoir fluid comprising water, or water and an acidic compound, or water and a basic compound, wherein in operation, the solid composition is exposed to the reservoir fluid which dissolves the solid composition and causes it to generate a gas, the gas being a driving fluid to dispense a beneficial agent. The present invention further provides a fluid driven dispensing device for delivering an agent into an environment of use, the device be driven by the gas generating engine.
摘要翻译: 本发明提供一种用于驱动有益剂分配装置的气体发生发动机。 所述发动机包括(a)包含酸性化合物或碱性化合物或其组合的固体组合物,和(b)用于使暴露于包含水或水的储液器的固体组合物的表面积基本上恒定的装置 和酸性化合物,或水和碱性化合物,其中在操作中,固体组合物暴露于溶解固体组合物并使其产生气体的储层流体,气体是用于分配有益剂的驱动流体。 本发明还提供一种用于将试剂输送到使用环境中的流体驱动分配装置,该装置由气体发生引擎驱动。
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