公开(公告)号：US5210202A

公开(公告)日：1993-05-11

申请号：US811673

申请日：1991-12-23

申请人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono ,  Gilbert Peiffer

发明人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono ,  Gilbert Peiffer

IPC分类号： B01J31/18 ,  B01J31/00 ,  B01J31/24 ,  C07B31/00 ,  C07B53/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/32 ,  C07C2/42 ,  C07C2/46 ,  C07C2/52 ,  C07C11/02 ,  C07C13/20 ,  C07C29/136 ,  C07C29/88 ,  C07C33/22 ,  C07C45/49 ,  C07C45/50 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07F7/18 ,  C07F9/46 ,  C07F9/50 ,  C07F9/53 ,  C07F9/572 ,  C07F15/00

CPC分类号： C07F15/0073 ,  C07C2/465 ,  C07C2/52 ,  C07C45/505 ,  C07F7/188 ,  C07F9/46 ,  C07F9/572 ,  C07C2101/16 ,  C07C2531/22

摘要： Chiral phosphorus-containing ligands comprising at least one amine radical and at least one dihydrocarbylphosphinoxy radical of the formula W=OP (R).sub.2, in which R is a hydrocarbon radical selected from the group consisting of alkyl, aryl, and cycloalkyl radicals, wherein the ligand is selected from the group consisting of:those of the formula ##STR1## those of the forumula ##STR2## those of the formula ##STR3## those of the formula ##STR4##

摘要翻译： 包含至少一个胺基团和至少一个式W = OP（R）2的二烃基次膦基的手性含磷配体，其中R是选自烷基，芳基和环烷基的烃基，其中 该配体选自：式（I）的化合物（I）的化合物的组合（II）的那些式

公开(公告)号：US5099077A

公开(公告)日：1992-03-24

申请号：US398539

申请日：1989-10-11

申请人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono ,  Gilbert Peiffer

发明人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono ,  Gilbert Peiffer

IPC分类号： B01J31/18 ,  B01J31/00 ,  B01J31/24 ,  C07B31/00 ,  C07B53/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/32 ,  C07C2/42 ,  C07C2/46 ,  C07C2/52 ,  C07C11/02 ,  C07C13/20 ,  C07C29/136 ,  C07C29/88 ,  C07C33/22 ,  C07C45/49 ,  C07C45/50 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07F7/18 ,  C07F9/46 ,  C07F9/50 ,  C07F9/53 ,  C07F9/572 ,  C07F15/00

CPC分类号： C07F15/0073 ,  C07C2/465 ,  C07C2/52 ,  C07C45/505 ,  C07F7/188 ,  C07F9/46 ,  C07F9/572 ,  C07C2101/16 ,  C07C2531/22

摘要： A method of using a chiral phosphorus-containing ligands comprising at least one amine radical and at least one dihydrocarbylphosphioxy radical of the formula W=OP (R).sub.2 ; from the group consisting of:those of the formula ##STR1## those of the formula ##STR2## those of the formula ##STR3## those of the formula ##STR4## in a hydrogenation reaction for the synthesis of optically active organic compounds comprising reacting at least one organic compound that does not possess a center of asymmetry with (A), on the one hand, at least one transition metal complex of the formula MZq in which M is a metal in group VIII of the Periodic Classification, q is the coordination number of the metal M, and Z is an atom or molecule capable of complexing the metal M and (B), on the other hand, at least one ligand L.

公开(公告)号：US4877908A

公开(公告)日：1989-10-31

申请号：US107919

申请日：1987-10-13

申请人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono

发明人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono

IPC分类号： B01J31/18 ,  B01J31/00 ,  B01J31/24 ,  C07B31/00 ,  C07B53/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/32 ,  C07C2/42 ,  C07C2/46 ,  C07C2/52 ,  C07C11/02 ,  C07C13/20 ,  C07C29/136 ,  C07C29/88 ,  C07C33/22 ,  C07C45/49 ,  C07C45/50 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07F7/18 ,  C07F9/46 ,  C07F9/50 ,  C07F9/53 ,  C07F9/572 ,  C07F15/00

CPC分类号： C07F15/0073 ,  C07C2/465 ,  C07C2/52 ,  C07C45/505 ,  C07F7/188 ,  C07F9/46 ,  C07F9/572 ,  C07C2101/16 ,  C07C2531/22

摘要： Chiral phosphorus-containing ligands comprising at least one amine radical and at least one dihydrocarbylphosphinoxy radical of the formula W=OP (R).sub.2, in which R is a hydrocarbon radical selected from the group consisting of alkyl, aryl, and cycloalkyl radicals, wherein the ligand is selected from the group consisting of:those of the formula ##STR1## those of the formula ##STR2## those of the formula ##STR3## those of the formula ##STR4## in which formulae: R.sub.1 and R.sub.2 are selected from the group consisting of a hydrogen atom and hydrocarbon radicals;R.sub.3 and R.sub.4, which must be different from one another, are selected from the group consisting of a hydrogen atom and hydrocarbon radicals that may or may not carry at least one functional group selected from the group consisting of the alcohol, thiol, thioether, amine, imine, acid, ester, amide, and ether functional groups; andR.sub.5 and R.sub.6 are selected from the group consisting of hydrogen atoms and hydrocarbon radicals that may or may not contain functional groups.A process for their manufacture comprises reacting an optically active amino alcohol, in a hydrocarbon solvent at a temperature between -50.degree. and 80.degree. C. and under an inert gas atmosphere, with at least one compound of the formula P(R).sub.2 Y in which Y is chosen from among the halogen atoms and amine radicals, the compound being present in a molar ratio, relative to the amino alcohol, greater than or equal to the number of P(R).sub.2 groups to be introduced into the chiral molecule.The chiral phosphorous-containing ligands are used by reacting at least one organic compound that does not possess a center of asymmetry with (A), on the one hand, at least one transition metal complex of formula MZq in which M is a metal in group VIII of the Periodic Classification, q is the coordination number of the metal M, and Z is an atom or molecule capable of complexing the metal M and (B), on the other hand, at least one ligand L.