公开(公告)号：US09127054B2

公开(公告)日：2015-09-08

申请号：US13992567

申请日：2011-12-05

申请人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

发明人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

IPC分类号： C07K16/18 ,  G01N33/577 ,  G01N33/574

CPC分类号： C07K16/18 ,  C07K2317/34 ,  G01N33/57446 ,  G01N33/577

摘要： An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

摘要翻译： 本发明的目的是实现特异性识别椰子蛋白1蛋白的抗体或其片段，以及检测和检测具有高检测性能的胃肠癌的方法，其包括使用抗体或免疫球蛋白进行免疫测定 片段。 使用两种或更多种类型的抗-cofilin1单克隆抗体或其片段特异性识别构成所述辅酶1蛋白的氨基酸序列中的不同肽区域的方法，对样品中的菲菲林1或其片段进行测定。

公开(公告)号：US20140363825A1

公开(公告)日：2014-12-11

申请号：US14241656

申请日：2012-08-28

申请人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

发明人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

IPC分类号： G01N33/574

CPC分类号： G01N33/57496 ,  C07K16/18 ,  C07K16/3046 ,  G01N33/57419

摘要： This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.

摘要翻译： 本发明涉及一种用于检测或检查选自结肠直肠癌和食管癌的癌症的方法，其具有高检测灵敏度和准确性并且对受试者的侵袭性较小。 具体地，本发明涉及一种用于检查癌症的方法，其包括在体外测量来自受试者的体液样品中的COTL1蛋白质，并基于所测量的COTL1蛋白质评估受试者是否患有癌症。 它还涉及用于诊断选自结肠直肠癌和食管癌的癌症的试剂盒，其包含能够特异性结合蛋白质的抗体或其片段。

公开(公告)号：US20130288277A1

公开(公告)日：2013-10-31

申请号：US13992567

申请日：2011-12-05

申请人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

发明人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

IPC分类号： C07K16/18 ,  G01N33/577

CPC分类号： C07K16/18 ,  C07K2317/34 ,  G01N33/57446 ,  G01N33/577

摘要： An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

摘要翻译： 本发明的目的是实现特异性识别椰子蛋白1蛋白的抗体或其片段，以及检测和检测具有高检测性能的胃肠癌的方法，其包括使用抗体或免疫球蛋白进行免疫测定 片段。 使用两种或更多种类型的抗-cofilin1单克隆抗体或其片段特异性识别构成所述辅酶1蛋白的氨基酸序列中的不同肽区域的方法，对样品中的菲菲林1或其片段进行测定。

公开(公告)号：US20120329074A1

公开(公告)日：2012-12-27

申请号：US13582316

申请日：2011-03-03

申请人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

发明人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

IPC分类号： G01N33/574

CPC分类号： G01N33/57446 ,  G01N2333/4712

摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

摘要翻译： 目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。 本发明提供了一种方法，其包括在源自人类受检者的体液样品中体外测量COTL1蛋白，其变体和/或其片段的量，并检测影响测试的胃癌的存在或不存在 基于该量的受试者，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

公开(公告)号：US20130011865A1

公开(公告)日：2013-01-10

申请号：US13582382

申请日：2011-03-03

申请人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

发明人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

IPC分类号： G01N33/574 ,  G01N21/64 ,  C07K16/18

CPC分类号： G01N33/57446 ,  C07K14/4702 ,  G01N33/57488

摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of Cofilin 1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

摘要翻译： 目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。 本发明提供了一种方法，其包括在体外测定源自人类受检者的体液样品中的Cofilin1蛋白，其变体和/或其片段的量，并检测是否存在影响 基于该量的测试对象，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

公开(公告)号：US09081013B2

公开(公告)日：2015-07-14

申请号：US13582316

申请日：2011-03-03

申请人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

发明人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

IPC分类号： G01N33/53 ,  G01N33/574

CPC分类号： G01N33/57446 ,  G01N2333/4712

摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

摘要翻译： 目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。 本发明提供了一种方法，其包括在源自人类受检者的体液样品中体外测量COTL1蛋白，其变体和/或其片段的量，并检测影响测试的胃癌的存在或不存在 基于该量的受试者，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

公开(公告)号：US20070112458A1

公开(公告)日：2007-05-17

申请号：US10562219

申请日：2004-05-25

申请人： Toshiyuki Kondo ,  Ryo Nakajima ,  Shin Yoshida ,  Tetsuya Ozawa ,  Yoshiharu Sakai

发明人： Toshiyuki Kondo ,  Ryo Nakajima ,  Shin Yoshida ,  Tetsuya Ozawa ,  Yoshiharu Sakai

IPC分类号： B25J13/08

CPC分类号： B66C13/18 ,  B25J9/026 ,  B25J13/085 ,  B62D65/18

摘要： To provide an assist transportation device capable of properly communicating a reaction force to a worker due to contact without damaging any product and obstacle even if the product contacts the obstacle under work. The assist transportation device for reducing a load applied to the worker when the worker operates transportation means to transport an instrument panel P includes instrument panel holding means 27 for holding the instrument panel P, floating mechanism 30 set to the connection portion between the instrument panel holding means 27 and the transportation means, displacement sensor 61 for detecting the displacement value of the floating mechanism 30, and position instruction computing portion 62 for computing the displacement value detected by the displacement sensor 61 to calculate a reaction force, in which the reaction force is transferred to the worker operating the transportation means.

摘要翻译： 为了提供一种辅助运输装置，即使产品与工作中的障碍物接触，能够由于接触而正确地向工作者传达反作用力而不损害任何产品和障碍物。 当工作人员操作运送仪器面板P的运送装置时，用于减少施加到工作人员的负荷的辅助运送装置包括用于保持仪表板P的仪表板保持装置27，设置在仪表板保持装置 装置27和运送装置，用于检测浮动机构30的位移值的位移传感器61和位置指令计算部62，用于计算由位移传感器61检测的位移值，以计算反作用力为 转移到经营运输工具的工人。

公开(公告)号：US06290358B1

公开(公告)日：2001-09-18

申请号：US09481759

申请日：2000-01-11

申请人： Yoshiharu Sakai ,  Kazuhiro Inoko

发明人： Yoshiharu Sakai ,  Kazuhiro Inoko

IPC分类号： G03B2100

CPC分类号： G02B5/3016

摘要： A polarized-light converting elemental device which can produce an accurately unidirectionally and circularly polarized light with a minimized loss of light and a projection-type display device using said unidirectionally-polarized-light converting elemental device are provided. A polarized-light converting elemental device comprises a mirror glass portion consisting of an array of mirror glass blocks each having a first reflecting optical element and a second reflecting optical element and a cholesteric-liquid-crystal glass portion including a cholesteric liquid crystal layer for reflecting either clockwise circularly polarized component or anticlockwise circularly polarized component and transmitting the other.

摘要翻译： 提供一种可以产生具有最小化光损失的精确单向和圆偏振光并使用所述单向偏振光转换元件的投射型显示装置的偏振光转换元件装置。 偏振光转换元件包括由玻璃镜阵列组成的镜玻璃部分，每个镜玻璃块具有第一反射光学元件和第二反射光学元件，胆甾型液晶玻璃部分包括用于反射的胆甾型液晶层 顺时针圆偏振分量或逆时针圆偏振分量，并传输另一个。

公开(公告)号：US08024067B2

公开(公告)日：2011-09-20

申请号：US11915289

申请日：2006-05-24

申请人： Yoshiharu Sakai ,  Tetsuya Ozawa ,  Kazuyoshi Fukuzawa ,  Yoshito Ohtake ,  Hiroki Baba

发明人： Yoshiharu Sakai ,  Tetsuya Ozawa ,  Kazuyoshi Fukuzawa ,  Yoshito Ohtake ,  Hiroki Baba

IPC分类号： G06F19/00

CPC分类号： B25J19/06 ,  B25J9/1676 ,  F16P3/144 ,  F16P3/147 ,  G05B19/4061 ,  G05B2219/37275 ,  G05B2219/39097 ,  G05B2219/39098 ,  G05B2219/40607 ,  G05B2219/49138

摘要： Immediately before a robot 20 starts to move at a high speed, a monitoring area 53 is expanded in a returning direction Y, and absence of an obstacle in the monitoring area 53 is confirmed. During the high speed movement of the robot 20, the monitoring area 53 is expanded forward, so that a safety of an operator is secured, an effective use of a working station area can be made, and an improvement of productivity can be achieved.

摘要翻译： 在机器人20开始高速移动之前，监视区域53在返回方向Y上扩大，并且确认监视区域53中没有障碍物。 在机器人20的高速运动期间，监视区域53向前扩展，从而确保操作者的安全性，可以有效地利用工作站区域，并且可以实现生产率的提高。

公开(公告)号：US5706213A

公开(公告)日：1998-01-06

申请号：US610288

申请日：1996-03-04

申请人： Keiji Takakura ,  Sigemitu Nakamura ,  Hiroshi Nagano ,  Ichirou Kouno ,  Yoshiharu Sakai

发明人： Keiji Takakura ,  Sigemitu Nakamura ,  Hiroshi Nagano ,  Ichirou Kouno ,  Yoshiharu Sakai

IPC分类号： B23Q41/00 ,  B65G61/00 ,  G05B19/05 ,  G05B19/418 ,  G06Q50/00 ,  G06Q50/04 ,  G06F11/32

CPC分类号： G05B19/41875 ,  Y02P90/18 ,  Y02P90/22

摘要： When operating preference settings are selected on a setting image on a CRT through a touch panel, an operating preference setting unit controls the CRT to display a menu for establishing settings for connection of inspecting devices in respective processes of a production line and names with respect to data delivered from the inspecting devices, in coaction with the touch panel. After the settings have been made, the CRT displays an image based on which the generation of a server image is indicated. Under the control of a server image generating unit, it is determined whether items related by the operating preference setting unit are to be displayed or not, generating a displayed image. When a server operation is indicated on an image next displayed on the CRT, data delivered from the inspecting devices are processed according to conditions indicated by the operating preference setting unit and a server operating unit, and displayed on the CRT under the control of the server operating unit. In the production line for manufacturing parts and assemblies, the operator can establish and enter parameters relative to inspection processes through the touch panel on an interactive basis with the CRT, so that quality control data from the inspection processes can be processed and managed altogether without the need for the operator to be knowledgeable in programming.

摘要翻译： 当通过触摸面板在CRT上的设置图像上选择了工作偏好设置时，工作偏好设置单元控制CRT以显示用于在生产线各自的处理中建立检查装置连接的设置的菜单，并且关于 与检测设备交付的数据与触摸面板协同工作。 在进行设置之后，CRT显示一个图像，基于该图像指示服务器映像的生成。 在服务器图像产生单元的控制下，确定是否要显示与操作偏好设置单元相关的项目，生成显示的图像。 当在下一次显示在CRT上的图像上指示服务器操作时，根据操作偏好设置单元和服务器操作单元指示的条件处理从检查设备发送的数据，并且在服务器的控制下显示在CRT上 操作单元 在制造零件和组装的生产线中，操作人员可以通过触摸屏与CRT进行交互式建立和输入相对于检测过程的参数，使得来自检验过程的质量控制数据可以一起处理和管理，而不需要 需要操作员知识编程。