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    MARKER FOR DETECTING GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER
    1.
    发明申请
    MARKER FOR DETECTING GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER 有权
    用于检测胃癌的标记物和用于检测胃癌的方法

    公开(公告)号：US20120329074A1

    公开(公告)日：2012-12-27

    申请号：US13582316

    申请日：2011-03-03

    申请人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    发明人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57446 ,  G01N2333/4712

    摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

    摘要翻译： 目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。 本发明提供了一种方法，其包括在源自人类受检者的体液样品中体外测量COTL1蛋白，其变体和/或其片段的量，并检测影响测试的胃癌的存在或不存在 基于该量的受试者，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

    Marker for detecting gastric cancer and method for detecting gastric cancer
    4.
    发明授权
    Marker for detecting gastric cancer and method for detecting gastric cancer 有权
    检测胃癌的标志物和检测胃癌的方法

    公开(公告)号：US09081013B2

    公开(公告)日：2015-07-14

    申请号：US13582316

    申请日：2011-03-03

    申请人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    发明人： Yoshinori Tanaka ,  Satoko Kanamori ,  Michimoto Kobayashi ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    IPC分类号： G01N33/53 ,  G01N33/574

    CPC分类号： G01N33/57446 ,  G01N2333/4712

    摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

    摘要翻译： 目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。 本发明提供了一种方法，其包括在源自人类受检者的体液样品中体外测量COTL1蛋白，其变体和/或其片段的量，并检测影响测试的胃癌的存在或不存在 基于该量的受试者，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

    IMMUNOASSAY OF COFILIN 1 PROTEIN
    5.
    发明申请
    IMMUNOASSAY OF COFILIN 1 PROTEIN 有权
    COFILIN 1蛋白免疫

    公开(公告)号：US20130288277A1

    公开(公告)日：2013-10-31

    申请号：US13992567

    申请日：2011-12-05

    申请人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    发明人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Satoko Kanamori ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    IPC分类号： C07K16/18 ,  G01N33/577

    CPC分类号： C07K16/18 ,  C07K2317/34 ,  G01N33/57446 ,  G01N33/577

    摘要： An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

    摘要翻译： 本发明的目的是实现特异性识别椰子蛋白1蛋白的抗体或其片段，以及检测和检测具有高检测性能的胃肠癌的方法，其包括使用抗体或免疫球蛋白进行免疫测定 片段。 使用两种或更多种类型的抗-cofilin1单克隆抗体或其片段特异性识别构成所述辅酶1蛋白的氨基酸序列中的不同肽区域的方法，对样品中的菲菲林1或其片段进行测定。

    MARKER FOR DETECTING COLORECTAL CANCER OR ESOPHAGEAL CANCER AND METHOD FOR EXAMINING SUCH CANCER
    6.
    发明申请
    MARKER FOR DETECTING COLORECTAL CANCER OR ESOPHAGEAL CANCER AND METHOD FOR EXAMINING SUCH CANCER 审中-公开
    用于检测彩色癌或食道癌的标记和检查此类癌症的方法

    公开(公告)号：US20140363825A1

    公开(公告)日：2014-12-11

    申请号：US14241656

    申请日：2012-08-28

    申请人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    发明人： Michimoto Kobayashi ,  Yoshinori Tanaka ,  Aiko Takayama ,  Giman Jung ,  Yoshiharu Sakai ,  Hiroshi Okabe

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57496 ,  C07K16/18 ,  C07K16/3046 ,  G01N33/57419

    摘要： This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.

    摘要翻译： 本发明涉及一种用于检测或检查选自结肠直肠癌和食管癌的癌症的方法，其具有高检测灵敏度和准确性并且对受试者的侵袭性较小。 具体地，本发明涉及一种用于检查癌症的方法，其包括在体外测量来自受试者的体液样品中的COTL1蛋白质，并基于所测量的COTL1蛋白质评估受试者是否患有癌症。 它还涉及用于诊断选自结肠直肠癌和食管癌的癌症的试剂盒，其包含能够特异性结合蛋白质的抗体或其片段。

    Immunoassay method for human CXCL1 protein
    7.
    发明授权
    Immunoassay method for human CXCL1 protein 有权
    人类CXCL1蛋白免疫测定法

    公开(公告)号：US09309312B2

    公开(公告)日：2016-04-12

    申请号：US13126877

    申请日：2009-10-29

    申请人： Satoko Kanamori ,  Giman Jung ,  Yoshinori Tanaka ,  Aiko Takayama

    发明人： Satoko Kanamori ,  Giman Jung ,  Yoshinori Tanaka ,  Aiko Takayama

    IPC分类号： C07K16/24 ,  G01N33/68 ,  G01N33/543 ,  G01N33/563 ,  A61K39/00

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/543 ,  G01N33/6857 ,  G01N33/6863 ,  G01N2333/522

    摘要： An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.

    摘要翻译： 本发明的目的是高灵敏度地检测人CXCL1蛋白。 提供了人CXCL1蛋白的免疫测定方法，通过该方法，使用两种或更多种抗人CXCL1单克隆抗体或其片段测量样品中的人CXCL1或其片段，其中：所述两种或更多种类型的 抗人CXCL1单克隆抗体或其片段特异性识别作为构成人CXCL1蛋白的氨基酸序列的部分序列的SEQ ID NO：1-3所示的氨基酸序列的任何一个序列区域; 两种以上抗人CXCL1单克隆抗体或其片段特异性识别彼此不同的序列区。 提供了单克隆抗体或其片段，其各自特异性识别SEQ ID NO：1-3所示的氨基酸序列的任何一个序列区，并具有新的氨基酸序列。

    IMMUNOASSAY METHOD FOR HUMAN CXCL1 PROTEIN
    8.
    发明申请
    IMMUNOASSAY METHOD FOR HUMAN CXCL1 PROTEIN 有权
    人CXCL1蛋白免疫组化方法

    公开(公告)号：US20110287444A1

    公开(公告)日：2011-11-24

    申请号：US13126877

    申请日：2009-10-29

    申请人： Satoko Kanamori ,  Giman Jung ,  Yoshinori Tanaka ,  Aiko Takayama

    发明人： Satoko Kanamori ,  Giman Jung ,  Yoshinori Tanaka ,  Aiko Takayama

    IPC分类号： G01N33/577 ,  C07K16/24

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/543 ,  G01N33/6857 ,  G01N33/6863 ,  G01N2333/522

    摘要： An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.

    摘要翻译： 本发明的目的是高灵敏度地检测人CXCL1蛋白。 提供了人CXCL1蛋白的免疫测定方法，通过该方法，使用两种或更多种抗人CXCL1单克隆抗体或其片段测量样品中的人CXCL1或其片段，其中：所述两种或更多种类型的 抗人CXCL1单克隆抗体或其片段特异性识别作为构成人CXCL1蛋白的氨基酸序列的部分序列的SEQ ID NO：1-3所示的氨基酸序列的任何一个序列区域; 两种以上抗人CXCL1单克隆抗体或其片段特异性识别彼此不同的序列区。 提供了单克隆抗体或其片段，其各自特异性识别SEQ ID NO：1-3所示的氨基酸序列的任何一个序列区，并具有新的氨基酸序列。