公开(公告)号：US20220165558A1

公开(公告)日：2022-05-26

申请号：US17670854

申请日：2022-02-14

申请人： Micromass UK Limited

发明人： Steven Derek Pringle ,  Tamas Karancsi ,  Emrys Jones ,  Michael Raymond Morris ,  Julia Balog ,  James Ian Langridge ,  Zoltan Takats ,  Frances Bolt ,  Lajos Godorhazy ,  Daniel Szalay ,  Daniel Simon ,  Keith Richardson

IPC分类号： H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26

摘要： A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and el mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

公开(公告)号：US11295942B2

公开(公告)日：2022-04-05

申请号：US15555845

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Tamas Karancsi ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Steven Derek Pringle ,  Emrys Jones ,  Ian Trivett ,  Stephen O'Brien ,  Anthony Hesse ,  Matt Henderson ,  Alvin Chua ,  Zoltan Takats

IPC分类号： A61B17/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B5/00 ,  G01N27/626 ,  G16H20/00 ,  G16H10/40 ,  G16H50/20 ,  A61B1/273 ,  A61B5/0507 ,  A61B10/00 ,  A61B18/04 ,  A61B18/18 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  H01J49/00 ,  A61B5/145 ,  A61B18/00

摘要： An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.

公开(公告)号：US11289320B2

公开(公告)日：2022-03-29

申请号：US15555998

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Steven Derek Pringle ,  Tamas Karancsi ,  Emrys Jones ,  Michael Raymond Morris ,  Julia Balog ,  James Ian Langridge ,  Zoltan Takats ,  Frances Bolt ,  Lajos Godorhazy ,  Daniel Szalay ,  Daniel Simon ,  Keith Richardson

IPC分类号： H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  A61B18/00

摘要： A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

公开(公告)号：US11282688B2

公开(公告)日：2022-03-22

申请号：US15556022

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Zoltan Takats ,  Frances Bolt ,  Tamas Karancsi ,  Emrys Jones ,  Keith Richardson ,  Lajos Godorhazy ,  Daniel Szalay ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC分类号： H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

公开(公告)号：US11270876B2

公开(公告)日：2022-03-08

申请号：US15555758

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Emrys Jones ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC分类号： H01J49/00 ,  H01J49/04 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  G16B20/00 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

公开(公告)号：US11195709B2

公开(公告)日：2021-12-07

申请号：US16604461

申请日：2018-04-11

申请人： MICROMASS UK LIMITED

发明人： Emrys Jones ,  Steven Derek Pringle ,  Michael Raymond Morris

IPC分类号： H01J49/00 ,  H01J49/04 ,  H01J49/16

摘要： An ambient ionisation source unit (10) is provided comprising: a housing (12) containing a first device (14) for generating analyte material from a surface of a sample to be analysed and a sampling inlet (16) for receiving analyte material liberated from the surface of the sample. The position(s) of the first device and/or sampling inlet is (are) fixed relative to the housing. Thus, the first device and the sampling inlet are integrated into a single unit that can be installed onto the front-end of an ion analysis instrument with minimal or reduced user interaction.

公开(公告)号：US11037774B2

公开(公告)日：2021-06-15

申请号：US15556052

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Steven Derek Pringle ,  Emrys Jones ,  Michael Raymond Morris ,  Julia Balog ,  James Ian Langridge ,  Keith Richardson ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC分类号： H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

摘要： A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US11031222B2

公开(公告)日：2021-06-08

申请号：US15556064

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Steven Derek Pringle ,  Emrys Jones ,  Michael Raymond Morris ,  Julia Balog ,  James Ian Langridge ,  Keith Richardson ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC分类号： G01N33/92 ,  G01N3/00 ,  G01N9/00 ,  A61B90/13 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

摘要： A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US11574803B2

公开(公告)日：2023-02-07

申请号：US17531490

申请日：2021-11-19

申请人： Micromass UK Limited

发明人： Zoltán Takáts ,  Frances Bolt ,  Tamás Karancsi ,  Emrys Jones ,  Keith Richardson ,  Lajos Godorhazy ,  Daniel Szalay ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC分类号： H01J49/10 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

公开(公告)号：US11342170B2

公开(公告)日：2022-05-24

申请号：US15555845

申请日：2016-03-07

申请人： Micromass UK Limited

发明人： Tamas Karancsi ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Steven Derek Pringle ,  Emrys Jones ,  Ian Trivett ,  Stephen O'Brien ,  Anthony Hesse ,  Matt Henderson ,  Alvin Chua ,  Zoltan Takats

IPC分类号： A61B17/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B5/00 ,  G01N27/626 ,  G16H20/00 ,  G16H10/40 ,  G16H50/20 ,  A61B1/273 ,  A61B5/0507 ,  A61B10/00 ,  A61B18/04 ,  A61B18/18 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  H01J49/00 ,  A61B5/145 ,  A61B18/00

摘要： An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.