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1.发明申请公开(公告)号：US20160233071A1
公开(公告)日：2016-08-11
申请号：US15022576
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： David Gordon , Alexander Hooper , Daniel James Kenny , Richard Barrington Moulds , David Pugh , Kate Whyatt
CPC分类号： H01J49/167 , G01N30/7266 , H01J49/0031 , H01J49/165
摘要： A method of Electrospray ionisation is disclosed comprising passing a sample liquid through a liquid chromatography column, monitoring a liquid chromatography back pressure and varying a voltage applied to an Electrospray ionisation source electrode in dependence upon said monitored liquid chromatography back pressure.
摘要翻译： 公开了一种电喷雾离子化方法，其包括使样品液体通过液相色谱柱，监测液相色谱背压并根据所监测的液相色谱背压改变施加到电喷雾电离源极的电压。
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公开(公告)号：US09842727B2
公开(公告)日：2017-12-12
申请号：US15022444
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： David Gordon , Daniel James Kenny , Howard Read , Kate Whyatt
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/10
摘要： A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.
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公开(公告)号：US10679840B2
公开(公告)日：2020-06-09
申请号：US16256687
申请日：2019-01-24
申请人： Micromass UK Limited
发明人： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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公开(公告)号：US20160225601A1
公开(公告)日：2016-08-04
申请号：US15022396
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
CPC分类号： H01J49/167 , H01J49/0027 , H01J49/044 , H01J49/165
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≧100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
摘要翻译： 公开了一种质谱仪，其包括大气压力界面，其包括具有入口孔的气体锥体，其中所述气体锥体具有沿x轴布置的第一纵向轴线和电喷雾离子源，所述电喷雾离子源包括具有出口的第一毛细管， 第二纵向轴线和围绕第一毛细管的第二毛细管。 质谱仪还包括去溶剂化气体供应管和第一装置，其布置并适于经由第一毛细管供应分析物液体，使得液体以>200μL/ min的流速离开第一毛细管的出口。 所述质谱仪还包括第二装置，其布置并适于经由所述第二毛细管以80-150L / hr的流速提供喷雾器气体，其中所述第一毛细管的出口以距离x mm 沿着从气体入口孔的中心测量的沿x轴的距离，沿着y轴的距离ymm，从气体锥入口孔的中心测量，并且沿z轴的距离z mm，从 气锥入口孔的中心。 x轴，y轴和z轴相互正交。 去溶剂化气体供应管围绕第二毛细管并且质谱仪还包括第三装置，其布置并适于经由去溶剂化气体供应管以400-1200L / hr的流量供应去溶剂化气体， 并且适于将去溶剂化气体加热至≥100℃的温度;以及第四装置，其布置并适于以40-80L / hr的流速向锥形锥体供应锥形气体，并且其中x在 范围2.0-5.0mm，并且其中z / x的比率在1-5:1的范围内。
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公开(公告)号：US20190244800A1
公开(公告)日：2019-08-08
申请号：US16256687
申请日：2019-01-24
申请人： Micromass UK Limited
发明人： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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公开(公告)号：US20180102241A1
公开(公告)日：2018-04-12
申请号：US15837016
申请日：2017-12-11
申请人： MICROMASS UK LIMITED
发明人： David Gordon , Daniel James Kenny , Howard Read , Kate Whyatt
IPC分类号： H01J49/00
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/10
摘要： A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.
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公开(公告)号：US20220384168A1
公开(公告)日：2022-12-01
申请号：US17767227
申请日：2020-10-06
申请人： Micromass UK Limited
发明人： Jason Lee Wildgoose , Martin Raymond Green , Keith Richardson , Daniel James Kenny , David Gordon , Kate Whyatt
IPC分类号： H01J49/00 , G01N27/622
摘要： A method of mass spectrometry is disclosed comprising: a step (10) of analysing a reference compound in a first mass spectrometer and outputting mass spectral data in response thereto; a step (20) of analysing the reference compound in a second, different mass spectrometer and outputting mass spectral data in response thereto; and a step (30) of automatically adjusting an operational parameter, duty cycle (e.g. duty cycle of data acquisition), or acquired spectral data of at least one mass spectrometer such that, for the same (given) consumption of reference compound by the spectrometer, the statistical precision of quantification (the number of detected ions) and/or of mass measurement (the mass resolution) by the mass spectrometer is substantially the same as that of the other mass spectrometer. A similar method of ion mobility spectrometry is disclosed.
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公开(公告)号：US10325764B2
公开(公告)日：2019-06-18
申请号：US15837016
申请日：2017-12-11
申请人： Micromass UK Limited
发明人： David Gordon , Daniel James Kenny , Howard Read , Kate Whyatt
摘要： A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.
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公开(公告)号：US10236171B2
公开(公告)日：2019-03-19
申请号：US15022396
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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公开(公告)号：US09659760B2
公开(公告)日：2017-05-23
申请号：US15022576
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： David Gordon , Alexander Hooper , Daniel James Kenny , Richard Barrington Moulds , David Pugh , Kate Whyatt
CPC分类号： H01J49/167 , G01N30/7266 , H01J49/0031 , H01J49/165
摘要： A method of Electrospray ionization is disclosed comprising passing a sample liquid through a liquid chromatography column, monitoring a liquid chromatography back pressure and varying a voltage applied to an Electrospray ionization source electrode in dependence upon said monitored liquid chromatography back pressure.
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