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公开(公告)号:US11049708B2
公开(公告)日:2021-06-29
申请号:US16862039
申请日:2020-04-29
申请人: Micromass UK Limited
发明人: Tamas Karancsi , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Steven Derek Pringle , Emrys Jones , Ian Trivett , Stephen O'Brien , Anthony Hesse , Matt Henderson , Alvin Chua , Zoltan Takáts
IPC分类号: H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B5/00 , G01N27/626 , G16H20/00 , G16H10/40 , G16H50/20 , A61B1/273 , A61B5/0507 , A61B10/00 , A61B18/04 , A61B18/18 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , A61B5/145 , A61B18/00
摘要: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
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公开(公告)号:US11031231B2
公开(公告)日:2021-06-08
申请号:US16306834
申请日:2017-06-05
申请人: MICROMASS UK LIMITED
发明人: Steven Derek Pringle , Emrys Jones , Stephen O'Brien , Anthony Hesse , Mike Morris , Zoltan Takats
摘要: There is provided an apparatus comprising a first ion source (10) arranged and adapted to emit a spray of charged droplets (11), and a control system arranged and adapted to control one or more spatial properties of said spray of charged droplets (11) in use by automatically varying or adjusting one or more parameters of said first ion source.
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公开(公告)号:US10438786B2
公开(公告)日:2019-10-08
申请号:US15465070
申请日:2017-03-21
申请人: Micromass UK Limited
发明人: Ian Trivett , Stephen O'Brien , David Gordon
摘要: An attachment device for releasably attaching a fluid line to a fluid inlet or outlet is disclosed. The device comprises an attachment member for releasably engaging a fluid inlet or outlet, and an elastic member coupled to the attachment member. The attachment device is attachable to a fluid line such that the attachment member is moveable relative to the fluid line and such that movement of the attachment member relative to the fluid line causes elastic deformation of the elastic member.
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公开(公告)号:US20160230889A1
公开(公告)日:2016-08-11
申请号:US15023053
申请日:2014-09-17
申请人: MICROMASS UK LIMITED
发明人: Stephen O'Brien , Ian Trivett
CPC分类号: F16J15/025 , H01J49/24 , H01J49/26
摘要: A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove. The annular vacuum chamber seal comprises a main body portion and one or more blade or rib portions which protrude from the main body portion. The main body portion is located in the groove and the one or more blade or rib portions protrude above or beyond a surface of the first component. The second component is slid, in use, along the surface of the first component thereby deforming the one or more blade or rib portions so that the one or more blade or rib portions form a radial, diametric or piston seal between the first and second components.
摘要翻译: 公开了一种质谱仪,其包括第一部件,环形真空室密封件和第二部件。 第一个组件有一个凹槽。 环形真空室密封件包括主体部分和从主体部分突出的一个或多个刀片或肋部分。 主体部分位于槽中,并且一个或多个刀片或肋部突出在第一部件的表面之上或之上。 第二部件在使用中沿着第一部件的表面滑动,从而使一个或多个刀片或肋部分变形,使得一个或多个刀片或肋部分在第一和第二部件之间形成径向,直径或活塞密封 。
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公开(公告)号:US10410848B2
公开(公告)日:2019-09-10
申请号:US15947609
申请日:2018-04-06
申请人: Micromass UK Limited
发明人: Ian Trivett , Stephen O'Brien , Graeme Dutton
摘要: An apparatus for connecting an ionization probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.
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公开(公告)号:US20190244800A1
公开(公告)日:2019-08-08
申请号:US16256687
申请日:2019-01-24
申请人: Micromass UK Limited
发明人: Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
摘要: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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公开(公告)号:US10260632B2
公开(公告)日:2019-04-16
申请号:US15023053
申请日:2014-09-17
申请人: Micromass UK Limited
发明人: Stephen O'Brien , Ian Trivett
摘要: A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove. The annular vacuum chamber seal comprises a main body portion and one or more blade or rib portions which protrude from the main body portion. The main body portion is located in the groove and the one or more blade or rib portions protrude above or beyond a surface of the first component. The second component is slid, in use, along the surface of the first component thereby deforming the one or more blade or rib portions so that the one or more blade or rib portions form a radial, diametric or piston seal between the first and second components.
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公开(公告)号:US20160233072A1
公开(公告)日:2016-08-11
申请号:US15022691
申请日:2014-09-17
申请人: MICROMASS UK LIMITED
发明人: Stephen O'Brien , Ian Trivett
CPC分类号: H01J49/24 , F16J15/061 , H01J49/0027
摘要: A gasket seal for a mass spectrometer is disclosed. The gasket seal comprises a membrane having an outer profile and an inner profile and one or more protrusions. One or more ports are provided in the body of the membrane. In use a gas or fluid is supplied through at least one of the one or more ports via at least one of the one or more protrusions.
摘要翻译: 公开了用于质谱仪的垫圈密封件。 垫圈密封件包括具有外轮廓和内轮廓以及一个或多个突起的膜。 一个或多个端口设置在膜的主体中。 在使用中,气体或流体经由至少一个或多个突起中的至少一个通过一个或多个端口中的至少一个供应。
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公开(公告)号:US11295942B2
公开(公告)日:2022-04-05
申请号:US15555845
申请日:2016-03-07
申请人: Micromass UK Limited
发明人: Tamas Karancsi , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Steven Derek Pringle , Emrys Jones , Ian Trivett , Stephen O'Brien , Anthony Hesse , Matt Henderson , Alvin Chua , Zoltan Takats
IPC分类号: A61B17/00 , H01J49/04 , A61B10/02 , A61B17/32 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B5/00 , G01N27/626 , G16H20/00 , G16H10/40 , G16H50/20 , A61B1/273 , A61B5/0507 , A61B10/00 , A61B18/04 , A61B18/18 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , H01J49/00 , A61B5/145 , A61B18/00
摘要: An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.
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公开(公告)号:US10679840B2
公开(公告)日:2020-06-09
申请号:US16256687
申请日:2019-01-24
申请人: Micromass UK Limited
发明人: Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
摘要: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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