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1.发明授权Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones 失效新型2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代环戊烯酮
公开(公告)号：US4343949A
公开(公告)日：1982-08-10
申请号：US84237
申请日：1979-10-12
申请人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
发明人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
IPC分类号： C07C53/19 , C07C53/42 , C07C405/00 , C07D303/38 , C07D307/935 , C07D309/12 , C07F1/02 , C07F3/02 , C07F5/06 , C07C51/353 , C07C177/00
CPC分类号： C07D303/38 , C07C405/00 , C07C53/19 , C07C53/42 , C07D307/935 , C07D309/12 , C07F1/02 , C07F3/02 , C07F5/062
摘要： This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
摘要翻译： 本公开内容描述了2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代的环戊烯酮，其可用作制备某些11-羟基 - 和具有支气管扩张剂，降血压和抗溃疡活性的11-脱氧-9-酮（或羟基） - 前列环酸衍生物。
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2.发明授权Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones 失效新型2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代环戊烯酮
公开(公告)号：US4293704A
公开(公告)日：1981-10-06
申请号：US115833
申请日：1980-01-28
申请人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
发明人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
IPC分类号： C07C43/166 , C07C43/176 , C07C51/09 , C07C51/363 , C07C51/367 , C07C405/00 , C07D309/12 , C07F7/18
CPC分类号： C07F7/1896 , C07C405/00 , C07C43/166 , C07C43/176 , C07C51/09 , C07C51/363 , C07C51/367 , C07D309/12
摘要： This invention relates to novel 4-oxy-2-substituted-cyclopent-2-en-1-ones of the following general formula: ##STR1## and the optical antipodes, racemic mixtures, and diastereomeric mixtures thereof wherein p is an integer from 2 to 6, inclusive, and J is hydrogen or an appropriate and compatible blocking group such as tetrahydropyranyl or tri(lower alkyl)silyl. Suitable lower alkyl groups contemplated by the present invention are those having up to four carbon atoms such as methyl, ethyl, isopropyl, tert-butyl, etc.
摘要翻译： 本发明涉及以下通式的新型4-氧-2-取代的环戊-2-烯-1-酮：其中p是2的整数，其中p是2的整数， 至6，并且J为氢或适当和相容的封闭基团如四氢吡喃基或三（低级烷基）甲硅烷基。 本发明考虑的合适的低级烷基是具有至多四个碳原子的那些，例如甲基，乙基，异丙基，叔丁基等。
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3.发明授权Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclo-pentenones 失效新的2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代的环戊烯酮
公开(公告)号：US4179574A
公开(公告)日：1979-12-18
申请号：US835613
申请日：1977-09-22
申请人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
发明人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
IPC分类号： C07C29/42 , C07C53/19 , C07C53/42 , C07C405/00 , C07D303/38 , C07D307/935 , C07D309/12 , C07F1/02 , C07F3/02 , C07F5/06
CPC分类号： C07D303/38 , C07C29/42 , C07C405/00 , C07C53/19 , C07C53/42 , C07D307/935 , C07D309/12 , C07F1/02 , C07F3/02 , C07F5/062 , C07B2200/09
摘要： This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostenoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
摘要翻译： 本公开内容描述了2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代的环戊烯酮，其可用作制备某些11-羟基 - 和具有支气管扩张剂，降血压和抗溃疡活性的11-脱氧-9-酮（或羟基） - 草酸衍生物。
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4.发明授权Novel 11-hydroxy-9-keto-5,6-cis-13,14-cis-prostadienoic acid derivatives 失效新型11-羟基-9-酮-5,6-顺式-13,14-顺式 - 前列腺烯酸衍生物
公开(公告)号：US4123456A
公开(公告)日：1978-10-31
申请号：US769764
申请日：1977-02-17
申请人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
发明人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
IPC分类号： C07C29/42 , C07C29/62 , C07C43/164 , C07C45/00 , C07C51/09 , C07C51/353 , C07C51/60 , C07C53/19 , C07C59/205 , C07C59/46 , C07C59/82 , C07C59/86 , C07C59/88 , C07C59/90 , C07C405/00 , C07D309/12 , C07F1/02 , C07F3/02 , C07F5/06 , C07F7/18 , C07C177/00
CPC分类号： C07F7/1896 , C07C29/42 , C07C29/62 , C07C405/00 , C07C43/164 , C07C51/09 , C07C51/353 , C07C51/60 , C07C53/19 , C07C59/205 , C07C59/46 , C07C59/82 , C07C59/86 , C07C59/88 , C07C59/90 , C07D309/12 , C07F1/02 , C07F3/02 , C07F5/062 , C07B2200/09
摘要： This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
摘要翻译： 本公开描述了用作支气管扩张剂，降血压药，抗溃疡剂或作为中间体的某些11-羟基和11-脱氧-9-酮（或羟基） - 前列酸衍生物。
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5.发明授权Novel hydroxy substituted prostanoic acids, esters, congeners, intermediates and process 失效新型羟基取代的前列腺酸，酯，同系物，中间体和方法
公开(公告)号：US4439365A
公开(公告)日：1984-03-27
申请号：US58415
申请日：1979-07-18
申请人： Middleton B. Floyd, Jr. , Martin J. Weiss , John F. Poletto , Robert E. Schaub , Karel F. Bernady
发明人： Middleton B. Floyd, Jr. , Martin J. Weiss , John F. Poletto , Robert E. Schaub , Karel F. Bernady
IPC分类号： C07C29/143 , C07C29/42 , C07C43/12 , C07C45/00 , C07C45/63 , C07C51/60 , C07C405/00 , C07D303/38 , C07D307/935 , C07D309/12 , C07F1/00 , C07F5/06 , C07F9/54 , C09B11/06
CPC分类号： C07D303/38 , C07C29/143 , C07C29/42 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07C405/0033 , C07C43/12 , C07C51/60 , C07D307/935 , C07D309/12 , C07F1/00 , C07F5/062 , C07F9/5407 , C07B2200/09
摘要： This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.
摘要翻译： 本公开描述了可用作支气管扩张剂，抗溃疡剂或作为中间体的某些11-羟基和11-脱氧-9-酮（或羟基） - 前列环酸衍生物。
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6.发明授权Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones 失效新型2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代环戊烯酮
公开(公告)号：US4237316A
公开(公告)日：1980-12-02
申请号：US616790
申请日：1975-09-25
申请人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
发明人： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
IPC分类号： C07C33/42 , C07C43/166 , C07C43/176 , C07C51/09 , C07C51/363 , C07C51/367 , C07C405/00 , C07D309/12 , C07F7/18 , C07C51/353
CPC分类号： C07F7/1896 , C07C33/423 , C07C405/00 , C07C43/166 , C07C43/176 , C07C51/09 , C07C51/363 , C07C51/367 , C07D309/12
摘要： This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.
摘要翻译： 本公开描述了可用作制备E2，E3和F系列的同型或非前列腺素的中间体的新型4-氧-2-取代 - 环戊-2-烯-1-酮。
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公开(公告)号：USH83H
公开(公告)日：1986-07-01
申请号：US710771
申请日：1985-03-11
申请人： John F. Poletto , Seymour Bernstein
发明人： John F. Poletto , Seymour Bernstein
摘要： This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [ureylenebis-(phenylenesulfonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.
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8.发明授权Carbalkoxymethyl derivatives of rutin poly(H-)sulfate and method of use 失效芦丁聚（H-）硫酸酯的烷氧基甲基衍生物及其使用方法
公开(公告)号：US4342752A
公开(公告)日：1982-08-03
申请号：US273523
申请日：1981-06-15
IPC分类号： C07H17/065 , A61K31/70 , C07H13/04
CPC分类号： C07H17/065
摘要： Carbalkoxymethyl derivatives of rutin poly(H-)sulfate and salts thereof useful as complement inhibitors.
摘要翻译： 芦丁聚（H） - 硫酸酯的烷氧基甲基衍生物及其盐可用作补体抑制剂。
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公开(公告)号：US4968702A
公开(公告)日：1990-11-06
申请号：US298585
申请日：1989-01-17
IPC分类号： A61K31/47 , A61P29/00 , A61P37/00 , C07D215/52 , C07D401/10 , C07D498/04
CPC分类号： C07D215/52
摘要： Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.
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公开(公告)号：US4231958A
公开(公告)日：1980-11-04
申请号：US17204
申请日：1979-03-05
IPC分类号： C07C309/47 , C07C309/59 , C07C311/46 , C07C311/47 , C07C143/30
CPC分类号： C07C309/47 , C07C309/59 , C07C311/46 , C07C311/47
摘要： Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
摘要翻译： 氨基取代的亚苯基羰基（和磺酰基）亚氨基取代的苯磺酰亚氨基（和磺酰基）亚氨基羰基（和磺酰基）亚氨基取代的 - 亚磺酰基亚氨基 - 萘基磺酸六碱金属盐]，可用作温血动物补体系统的抑制剂 - 萘二磺酸，三碱金属盐，它们是制备活性芴烯的新中间体及其制备方法。
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