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公开(公告)号：US20120315335A1
公开(公告)日：2012-12-13
申请号：US13352637
申请日：2012-01-18
IPC分类号： A61K9/51 , A61K31/7088 , A61K38/02 , B82Y5/00
CPC分类号： A61K9/5184 , A61K9/1277 , A61K9/5192 , A61K47/6901 , A61K47/6913 , B82Y5/00 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , Y10S977/795 , Y10S977/797 , Y10S977/798 , Y10S977/80 , Y10S977/801 , Y10S977/802
摘要： A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the drug, a lipid bi-layer envelope and targeting or facilitating molecules anchored in the lipid bilayer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
摘要翻译： 提供了用于递送药物的自组装纳米颗粒药物递送系统，包括肽，蛋白质，核酸或合成化学药物。 本文所述的自组装纳米颗粒药物递送系统包括病毒衣壳蛋白，例如包封药物的乙型肝炎病毒核心蛋白，脂质双层包膜和靶向或促进锚定在脂质双层中的分子。 还提供了用于构建自组装纳米颗粒药物递送系统的方法。
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公开(公告)号：US08067011B2
公开(公告)日：2011-11-29
申请号：US11697945
申请日：2007-04-09
申请人： Claude Geoffrey Davis , Miguel A. de los Rios , Kenneth J. Oh , Timothy L. Bullock , Patrick T. Johnson , Jacek Ostrowski
发明人： Claude Geoffrey Davis , Miguel A. de los Rios , Kenneth J. Oh , Timothy L. Bullock , Patrick T. Johnson , Jacek Ostrowski
IPC分类号： A61K39/29 , A61K39/385 , C07K14/02
CPC分类号： A61K9/1272 , A61K9/5184 , A61K47/6849 , A61K47/6913 , A61K51/1234 , A61K2039/505 , A61K2039/5258 , C07K16/2803 , C07K16/3061 , C07K2317/77 , Y10S977/795 , Y10S977/797 , Y10S977/798 , Y10S977/80 , Y10S977/801 , Y10S977/802
摘要： The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells.
摘要翻译： 本发明提供了用于将细胞毒性剂递送至B细胞的靶向多层药物递送系统。
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公开(公告)号：US20170119689A1
公开(公告)日：2017-05-04
申请号：US15183167
申请日：2016-06-15
CPC分类号： A61K9/5184 , A61K9/1277 , A61K9/5192 , A61K47/6901 , A61K47/6913 , B82Y5/00 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , Y10S977/795 , Y10S977/797 , Y10S977/798 , Y10S977/80 , Y10S977/801 , Y10S977/802
摘要： A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the drug, a lipid bi-layer envelope and targeting or facilitating molecules anchored in the lipid bilayer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
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公开(公告)号：US20110293733A1
公开(公告)日：2011-12-01
申请号：US13085892
申请日：2011-04-13
IPC分类号： A61K9/14 , A61K31/711 , A61K39/395 , A61K31/7105 , A61P9/00 , A61P11/00 , A61P25/00 , A61P25/04 , A61P11/06 , A61P31/00 , A61P25/24 , A61P3/10 , A61P31/10 , A61P9/12 , A61P29/00 , A61P35/00 , A61P25/22 , A61P37/06 , A61P37/02 , A61P25/06 , A61P25/20 , A61P9/10 , A61P25/18 , A61P9/06 , A61P19/02 , A61P19/06 , A61P7/02 , A61P7/04 , A61P7/00 , A61P25/08 , A61P25/16 , A61P17/04 , A61P31/04 , A61P31/12 , A61P11/08 , A61P3/08 , A61P3/06 , A61P1/04 , A61P1/08 , A61P3/02 , A61K38/02
CPC分类号： A61K9/5184 , A61K9/1277 , A61K9/5192 , A61K47/6901 , A61K47/6913 , B82Y5/00 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , Y10S977/795 , Y10S977/797 , Y10S977/798 , Y10S977/80 , Y10S977/801 , Y10S977/802
摘要： A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the drug, a lipid bi-layer envelope and targeting or facilitating molecules anchored in the lipid bilayer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
摘要翻译： 提供了用于递送药物的自组装纳米颗粒药物递送系统，包括肽，蛋白质，核酸或合成化学药物。 本文所述的自组装纳米颗粒药物递送系统包括病毒衣壳蛋白，例如包封药物的乙型肝炎病毒核心蛋白，脂质双层包膜和靶向或促进锚定在脂质双层中的分子。 还提供了用于构建自组装纳米颗粒药物递送系统的方法。
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