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1.发明授权
公开(公告)号：US5369004A
公开(公告)日：1994-11-29
申请号：US922723
申请日：1992-07-31
CPC分类号： C12Q1/6876 , C12Q1/6858 , C12Q2600/156
摘要： The invention relates to polymorphic markers (two tetranucleotide, one dinucleotide repeat polymorphisms, 27 markers characterized by primer pairs 1A-27A, and five markers characterized by primer pairs 1B-5B that are useful for human individualization. Applications are in forensic medicine and for paternity and prenatal screening as well as genetic mapping. These markers are characterized by sets of oligonucleotide primers according to the invention useful in PCR amplification and DNA segment resolution. The invention further relates to an assay for measuring the subtle differences in genetic material regarding an added or omitted set of dinucleotide or tetranucleotide repeat polymorphisms which comprises obtaining an amount of nucleotide segments effective for testing, amplifying the segments by the PCR procedure using at least one primer nucleotide sequence according to the present invention, resolving the amplified segments using gel electrophoresis, and comparing the resolved segments by autoradiography to observe the differences in migration patterns due to structural differences. The assay according to the invention is easy to perform and results can be obtained within 24 hours. It is not uncommon for results to be available within 3-4 hours. Accordingly, the invention also relates to an improved PCR procedure and a PCR assay kit which comprise nucleotides according to the invention.
摘要翻译： 本发明涉及多态性标记（两个四核苷酸，一个二核苷酸重复多态性，以引物对1A-27A为特征的27个标记，以及用于人个体化的引物对1B-5B特征的5个标记，应用于法医学和亲子鉴定 本发明还涉及用于测量遗传物质中关于添加或添加的遗传物质的微妙差异的测定法， 省略了一组二核苷酸或四核苷酸重复多态性，其包括获得有效用于测试的量的核苷酸区段，使用至少一个本发明引物核苷酸序列通过PCR程序扩增片段，使用凝胶电泳解析扩增片段，并比较 解决的segme 通过放射自显影观察由于结构差异的迁移模式的差异。 根据本发明的测定容易进行，并且可以在24小时内获得结果。 结果在3-4小时内可以使用并不罕见。 因此，本发明还涉及包含根据本发明的核苷酸的改进的PCR方法和PCR测定试剂盒。
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公开(公告)号：US5721100A
公开(公告)日：1998-02-24
申请号：US480366
申请日：1995-06-07
CPC分类号： C12Q1/6858 , C12Q1/6876 , C12Q2600/156
摘要： The invention relates to polymorphic markers (two tetranucleotide and one dinucleotide repeat polymorphisms) that are useful for human individualization. Applications are in forensic medicine and for paternity and prenatal screening as well as genetic mapping. These markers are characterized by sets of oligonucleotide primers according to the invention useful in PCR amplification and DNA segment resolution. The invention further relates to an assay for measuring the subtle differences in genetic material regarding an added or omitted set of dinucleotide or tetranucleotide repeat polymorphisms which comprises obtaining an amount of nucleotide segments effective for testing, amplifying the segments by the PCR procedure using at least one primer nucleotide sequence according to the present invention, resolving the amplified segments using gel electrophoresis, and comparing the resolved segments by autoradiography to observe the differences in migration patterns due to structural differences. The assay according to the invention is easy to perform and results can be obtained within 24 hours. It is not uncommon for results to be available within 3-4 hours. Accordingly, the invention also relates to an improved PCR procedure and a PCR assay kit which comprise nucleotides according to the invention.
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3.发明授权Eleven highly informative microsatelite repeat polymorphic DNA markers 失效十一个高度信息的microsatelite重复多态性DNA标记
公开(公告)号：US5861504A
公开(公告)日：1999-01-19
申请号：US952277
申请日：1992-09-28
CPC分类号： C12Q1/6876 , C12Q1/6858 , C12Q2600/156
摘要： The invention relates to polymorphic markers (two tetranucleotide, one dinucleotide repeat polymorphisms, 27 markers characterized by primer pairs 1A-27A, and eleven markers characterized by primer pairs 1B-11B that are useful for human individualization. Applications are in forensic medicine and for paternity and prenatal screening as well as genetic mapping. These markers are characterized by sets of oligonucleotide primers according to the invention useful in PCR amplification and DNA segment resolution. The invention further relates to an assay for measuring the subtle differences in genetic material regarding an added or omitted set of dinucleotide or tetranucleotide repeat polymorphisms which comprises obtaining an amount of nucleotide segments effective for testing, amplifying the segments by the PCR procedure using at least one primer nucleotide sequence according to the present invention, resolving the amplified segments using gel electrophoresis, and comparing the resolved segments by autoradiography to observe the differences in migration patterns due to structural differences. The assay according to the invention is easy to perform and results can be obtained within 24 hours. It is not uncommon for results to be available within 3-4 hours. Accordingly, the invention also relates to an improved PCR procedure and a PCR assay kit which comprise nucleotides according to the invention.
摘要翻译： 本发明涉及多态性标记（两个四核苷酸，一个二核苷酸重复多态性，27个引物对1A-27A特征的标记，以及引物对1B-11B特征的11个标记，可用于人的个体化，应用于法医学和亲子鉴定 本发明还涉及用于测量遗传物质中关于添加或添加的遗传物质的微妙差异的测定法， 省略了一组二核苷酸或四核苷酸重复多态性，其包括获得有效用于测试的量的核苷酸区段，使用至少一个本发明引物核苷酸序列通过PCR程序扩增片段，使用凝胶电泳解析扩增片段，并比较 解决了 通过放射自显影来观察由于结构差异导致的迁移模式的差异。 根据本发明的测定容易进行，并且可以在24小时内获得结果。 结果在3-4小时内可以使用并不罕见。 因此，本发明还涉及包含根据本发明的核苷酸的改进的PCR方法和PCR测定试剂盒。
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4.发明授权
公开(公告)号：US5468610A
公开(公告)日：1995-11-21
申请号：US74275
申请日：1993-06-09
CPC分类号： C12Q1/6858 , C12Q1/6876 , C12Q2600/156
摘要： The invention relates to polymorphic markers (two tetranucleotide and one dinucleotide repeat polymorphisms) that are useful for human individualization. Applications are in forensic medicine and for paternity and prenatal screening as well as genetic mapping. These markers are characterized by sets of oligonucleotide primers according to the invention useful in PCR amplification and DNA segment resolution. The invention further relates to an assay for measuring the subtle differences in genetic material regarding an added or omitted set of dinucleotide or tetranucleotide repeat polymorphisms which comprises obtaining an amount of nucleotide segments effective for testing, amplifying the segments by the PCR procedure using at least one primer nucleotide sequence according to the present invention, resolving the amplified segments using gel electrophoresis, and comparing the resolved segments by autoradiography to observe the differences in migration patterns due to structural differences. The assay according to the invention is easy to perform and results can be obtained within 24 hours. It is not uncommon for results to be available within 3-4 hours. Accordingly, the invention also relates to an improved PCR procedure and a PCR assay kit which comprise nucleotides according to the invention.
摘要翻译： 本发明涉及可用于人类个体化的多态性标记（两个四核苷酸和一个二核苷酸重复多态性）。 应用于法医学和亲子鉴定和产前筛查以及基因测绘。 这些标记的特征在于本发明的可用于PCR扩增和DNA片段拆分的一组寡核苷酸引物。 本发明还涉及用于测量关于添加或省略的二核苷酸或四核苷酸重复多态性的集合的遗传物质的微妙差异的测定法，其包括获得有效测试的量的核苷酸区段，通过PCR程序使用至少一个 本发明的引物核苷酸序列，使用凝胶电泳解析扩增片段，并通过放射自显影比较分辨的片段以观察由于结构差异引起的迁移模式的差异。 根据本发明的测定容易进行，并且可以在24小时内获得结果。 结果在3-4小时内可以使用并不罕见。 因此，本发明还涉及包含根据本发明的核苷酸的改进的PCR方法和PCR测定试剂盒。
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公开(公告)号：US08586610B2
公开(公告)日：2013-11-19
申请号：US11576178
申请日：2005-09-30
IPC分类号： A61K31/445 , C12Q1/68
CPC分类号： A61K31/454 , A61K31/519 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.
摘要翻译： 本发明涉及用碘吡啶治疗后可能与QT延长风险相关的遗传多态性的鉴定方法，以及对具有这种多态性的患者施用伊氟哌啶酮的相关方法。
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公开(公告)号：US20110118313A1
公开(公告)日：2011-05-19
申请号：US12991766
申请日：2009-05-15
IPC分类号： A61K31/4535 , C12Q1/68 , C40B30/00 , A61K31/138 , A61P25/00 , A61P25/18
CPC分类号： A61K31/00 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5058 , G01N33/6896 , G01N33/92 , G01N2500/10 , G01N2800/302 , G01N2800/52
摘要： Molecular signature for antipsychotics and SERMs has been identified, namely their upregulation of genes that alter lipid homeostasis, preferably of one or more of the following genes: TNSIG1, SCD, FADS2, LDLR, FDPS, ACAT2, FDFT1, CYP51A1, FASN, DHCR7, RAB26, TM7SF2, SATB1, FAM117, GPNMB, NUPR1, VAC14, and LSS.
摘要翻译： 已经鉴定了抗精神病药和SERMs的分子特征，即其改变脂质体内平衡的基因的上调，优选一种或多种以下基因：TNSIG1，SCD，FADS2，LDLR，FDPS，ACAT2，FDFT1，CYP51A1，FASN，DHCR7， RAB26，TM7SF2，SATB1，FAM117，GPNMB，NUPR1，VAC14和LSS。
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7.发明申请METHOD AND COMPOSITION FOR TREATING A SERATONIN RECEPTOR-MEDIATED CONDITION 有权用于治疗SERATONIN受体介导的病症的方法和组合物公开(公告)号：US20110044971A1
公开(公告)日：2011-02-24
申请号：US12747912
申请日：2008-12-13
IPC分类号： A61K31/454 , A61P7/02 , A61P9/10 , A61P11/06 , C07D413/04 , A61K31/4365 , A61K38/48 , A61K38/49 , A61K38/17 , A61K31/616
CPC分类号： A61K31/454 , A61K31/445 , A61K45/06 , A61K2300/00
摘要： A method and composition for treating serotonin receptor-mediated conditions.
摘要翻译： 用于治疗血清素受体介导的病症的方法和组合物。
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8.发明授权Genetic markers for efficacy of iloperidone in the treatment of psychotic symptoms 有权伊立替尼治疗精神病症状的有效性的遗传标记公开(公告)号：US09080214B2
公开(公告)日：2015-07-14
申请号：US12600036
申请日：2008-05-17
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Methods for predicting whether iloperidone will be efficacious in treating a psychotic symptom in an individual, based on the individual's genotype at one or more single nucleotide polymorphism (SNP) loci are described, as are methods for treating an individual based on such prediction.
摘要翻译： 描述了基于个体在一个或多个单核苷酸多态性（SNP）基因座上的基因型是否依据碘吡啶酮治疗个体精神病症状有效的方法，以及基于这种预测治疗个体的方法。
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9.发明申请PREDICTION OF SLEEP PARAMETER AND RESPONSE TO SLEEP-INDUCING COMPOUND BASED ON PER3 VNTR GENOTYPE 审中-公开基于PER3 VNTR基因组预测睡眠参数和对休眠诱导化合物的反应公开(公告)号：US20100261786A1
公开(公告)日：2010-10-14
申请号：US12675614
申请日：2008-09-12
IPC分类号： A61K31/343 , G01N33/50 , C07D307/81 , A61P25/00
CPC分类号： C12Q1/6883 , A61K31/16 , C12Q2600/106 , C12Q2600/156 , Y10T436/143333
摘要： The invention relates to the prediction of a sleep parameter (e.g., sleep efficiency (SE), latency to persistent sleep (LPS), wake after sleep onset (WASO), total sleep time (TST)) of an individual and the response of such an individual to a sleep inducing compound based on the individual's PER3 variable number tandem repeat (VNTR) genotype.
摘要翻译： 本发明涉及预测个体的睡眠参数（例如，睡眠效率（SE）），持续睡眠（LPS）潜伏期，睡眠发作后唤醒（WASO），总睡眠时间（TST））以及其响应 基于个人的PER3可变序列串联重复（VNTR）基因型的睡眠诱导化合物的个体。
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公开(公告)号：US20090306137A1
公开(公告)日：2009-12-10
申请号：US12301675
申请日：2007-05-21
IPC分类号： A61K31/454 , A61P25/24
CPC分类号： A61K31/454 , A61K45/06 , A61K2300/00
摘要： A method of treating depression comprising administering a melatonin agonist.
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