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公开(公告)号：US09249230B2
公开(公告)日：2016-02-02
申请号：US12365784
申请日：2009-02-04
申请人： Mike Rothe , Martin Treder , Eric Borges , Susanne Hartmann , Larry L. Green
发明人： Mike Rothe , Martin Treder , Eric Borges , Susanne Hartmann , Larry L. Green
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , G01N33/574 , A61K39/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20120058122A1
公开(公告)日：2012-03-08
申请号：US12761370
申请日：2010-04-15
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges , Larry L. Green
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges , Larry L. Green
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US07705130B2
公开(公告)日：2010-04-27
申请号：US11649722
申请日：2007-01-03
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Eric Borges , Larry L. Green
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Eric Borges , Larry L. Green
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US08771695B2
公开(公告)日：2014-07-08
申请号：US12761370
申请日：2010-04-15
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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5.发明申请公开(公告)号：US20110110956A1
公开(公告)日：2011-05-12
申请号：US12680191
申请日：2008-09-26
申请人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
发明人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
CPC分类号： C07K16/22 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor.
摘要翻译： 本文提供了抗原结合蛋白，例如对肝素结合表皮生长因子样生长因子（HB-EGF）具有亲和力并中和该生长因子的生物学功能的人和/或单克隆抗体。
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6.发明授权公开(公告)号：US08828382B2
公开(公告)日：2014-09-09
申请号：US12680191
申请日：2008-09-26
申请人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
发明人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
IPC分类号： A61K39/395 , C07K16/22 , C12P21/08 , C07H21/04
CPC分类号： C07K16/22 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor.
摘要翻译： 本文提供抗原结合蛋白，例如对肝素结合表皮生长因子样生长因子（HB-EGF）具有亲和力并中和该生长因子的生物学功能的人和/或单克隆抗体。
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公开(公告)号：US20100189722A1
公开(公告)日：2010-07-29
申请号：US12672378
申请日：2008-08-08
IPC分类号： A61K39/395 , C07K16/16 , C07H21/04 , C12N15/74 , C12N5/10 , C12P21/00 , A61P35/00 , A61P35/02
CPC分类号： C07K16/28 , A01K67/0275 , A01K2207/15 , A01K2217/072 , A01K2227/105 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K2317/24 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Chimeric and humanized anti-CD37 antibodies and pharmaceutical compositions containing them are useful for the treatment of B cell malignancies and autoimmune and inflammatory diseases that involve B cells in their pathology.
摘要翻译： 嵌合和人源化抗CD37抗体和含有它们的药物组合物可用于治疗涉及B细胞病理学的B细胞恶性肿瘤和自身免疫性和炎性疾病。
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8.发明授权Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof 有权阻断受体蛋白酪氨酸激酶激活的抗体，筛选方法及其应用公开(公告)号：US08828385B2
公开(公告)日：2014-09-09
申请号：US12394756
申请日：2009-02-27
申请人： Avner Yayon , Eran Rom , Elisabeth Thomassen-Wolf , Eric Borges
发明人： Avner Yayon , Eran Rom , Elisabeth Thomassen-Wolf , Eric Borges
CPC分类号： C07K16/3038 , A61K38/00 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： Molecules comprising the antigen-binding portion of antibodies that block constitutive and/or ligand-dependent activation of a receptor protein tyrosine kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found through screening methods, where a soluble dimeric form of a receptor protein tyrosine kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat or inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase.
摘要翻译： 通过筛选方法发现包含阻断受体蛋白酪氨酸激酶（例如成纤维细胞生长因子受体3（FGFR3））的组成型和/或配体依赖性激活的抗体的抗原结合部分的分子，其中可溶性二聚体形式的 受体蛋白酪氨酸激酶用作筛选噬菌体表面上显示的抗体片段的文库的靶标。 可以施用阻断组成型活化的本发明的分子，以治疗或抑制骨骼发育不良，颅缝管瘤病，细胞增殖性疾病或病症，或与受体蛋白酪氨酸激酶的组成型激活相关的肿瘤进展。
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9.发明申请AGENTS AND METHODS FOR TREATING DISEASES THAT CORRELATE WITH BCMA EXPRESSION 审中-公开用于治疗与BCMA表达相关的疾病的代理和方法公开(公告)号：US20130273055A1
公开(公告)日：2013-10-17
申请号：US13885646
申请日：2011-11-16
申请人： Eric Borges , Jasmin Barbara Hebeis
发明人： Eric Borges , Jasmin Barbara Hebeis
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/2809 , C07K16/2878 , C07K2317/31
摘要： A bispecific binding agent comprising at least two binding domains, wherein a first binding domain binds to the B cell maturation antigen BCMA and wherein a second binding domain binds to CD3, pharmaceutical compositions containing such agent and use for the treatment of plasma cell disorders or B cell disorders which correlate with BCMA expression.
摘要翻译： 包含至少两个结合结构域的双特异性结合剂，其中第一结合结构域结合B细胞成熟抗原BCMA，并且其中第二结合结构域与CD3结合，含有该药剂的药物组合物和用于治疗浆细胞疾病或B 与BCMA表达相关的细胞病症。
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公开(公告)号：US09079958B2
公开(公告)日：2015-07-14
申请号：US13246022
申请日：2011-09-27
申请人： Renate Konopitzky , Eric Borges , Paul Adam , Karl-Heinz Heider
发明人： Renate Konopitzky , Eric Borges , Paul Adam , Karl-Heinz Heider
CPC分类号： C07K16/2803 , C07K16/2851 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS).
摘要翻译： 本发明涉及基于骨髓细胞消耗的免疫疗法。 特别地，本发明涉及用于此类疗法的CD33结合剂，例如， 治疗骨髓细胞恶性肿瘤和骨髓增生异常综合征（MDS）。
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