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公开(公告)号：US09249230B2
公开(公告)日：2016-02-02
申请号：US12365784
申请日：2009-02-04
申请人： Mike Rothe , Martin Treder , Eric Borges , Susanne Hartmann , Larry L. Green
发明人： Mike Rothe , Martin Treder , Eric Borges , Susanne Hartmann , Larry L. Green
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , G01N33/574 , A61K39/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20120058122A1
公开(公告)日：2012-03-08
申请号：US12761370
申请日：2010-04-15
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges , Larry L. Green
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges , Larry L. Green
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US07705130B2
公开(公告)日：2010-04-27
申请号：US11649722
申请日：2007-01-03
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Eric Borges , Larry L. Green
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Eric Borges , Larry L. Green
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US08771695B2
公开(公告)日：2014-07-08
申请号：US12761370
申请日：2010-04-15
申请人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges
发明人： Mike Rothe , Martin Treder , Susanne Hartmann , Daniel J. Freeman , Robert Radinsky , Eric Borges
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20100183631A1
公开(公告)日：2010-07-22
申请号：US12365784
申请日：2009-02-04
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20080124345A1
公开(公告)日：2008-05-29
申请号：US11649722
申请日：2007-01-03
IPC分类号： A61K39/395 , A61P37/00 , C07H21/04 , C07K16/00 , C12N1/34 , C12N15/00 , C12N5/02 , C12N5/04 , G01N33/53
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/00 , C12N15/09 , C12N15/63 , C12N2800/00 , G01N33/574
摘要： The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
摘要翻译： 本发明涉及结合HER-3的结合蛋白和编码其的多核苷酸。 还提供了包含其用于产生本发明的结合蛋白的表达载体和宿主细胞。 此外，本发明提供用于诊断和治疗与HER-3介导的信号转导相关的疾病和/或其配体调节蛋白的组合物和方法。
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公开(公告)号：US20100047829A1
公开(公告)日：2010-02-25
申请号：US12516682
申请日：2007-11-28
申请人： Mike Rothe , Martin Treder
发明人： Mike Rothe , Martin Treder
CPC分类号： G01N33/5748 , A61K39/395 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/76 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N2333/71 , G01N2333/91205 , G01N2440/14 , G01N2800/205 , G01N2800/52
摘要： The present invention provides methods for the determination of the activation level of Receptor Tyrosine kinases, e.g. phosporylated HER3, for the selection of patients for disease treatment. Methods are also provided for the evaluation of the biological and pharmacodynamic effects of an active substance and/or its efficacy in disease treatment, utilizing a tissue sample from a test subject, for example tumor material or normal tissue such as skin or hair follicle. Further, methods for the treatment of HER receptor-associated diseases are disclosed.
摘要翻译： 本发明提供了用于测定受体酪氨酸激酶活化水平的方法，例如， 磷酸化HER3，用于选择患者进行疾病治疗。 还提供了用于评估活性物质的生物学和药效学效应和/或其在疾病治疗中的功效的方法，利用来自测试对象的组织样品，例如肿瘤材料或正常组织，例如皮肤或毛囊。 此外，公开了治疗HER受体相关疾病的方法。
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8.发明申请公开(公告)号：US20110110956A1
公开(公告)日：2011-05-12
申请号：US12680191
申请日：2008-09-26
申请人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
发明人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
CPC分类号： C07K16/22 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor.
摘要翻译： 本文提供了抗原结合蛋白，例如对肝素结合表皮生长因子样生长因子（HB-EGF）具有亲和力并中和该生长因子的生物学功能的人和/或单克隆抗体。
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9.发明授权公开(公告)号：US08828382B2
公开(公告)日：2014-09-09
申请号：US12680191
申请日：2008-09-26
申请人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
发明人： Mike Rothe , Norbert Prenzel , Eric Borges , Thore Hettmann , Esther Zwick-Wallasch , Orit Foord
IPC分类号： A61K39/395 , C07K16/22 , C12P21/08 , C07H21/04
CPC分类号： C07K16/22 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor.
摘要翻译： 本文提供抗原结合蛋白，例如对肝素结合表皮生长因子样生长因子（HB-EGF）具有亲和力并中和该生长因子的生物学功能的人和/或单克隆抗体。
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公开(公告)号：US08933202B2
公开(公告)日：2015-01-13
申请号：US12742546
申请日：2008-11-12
申请人： Thore Hettmann , Jens Niewöhner , Jens Ruhe , Peter Wirtz , Kerstin Selle , Esther Zwick-Wallasch , Mike Rothe
发明人： Thore Hettmann , Jens Niewöhner , Jens Ruhe , Peter Wirtz , Kerstin Selle , Esther Zwick-Wallasch , Mike Rothe
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395 , C07K16/28 , A61K31/282 , A61K31/704 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2863 , A61K31/282 , A61K31/704 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention refers to antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
摘要翻译： 本发明涉及结合AXL受体酪氨酸激酶的细胞外结构域并且至少部分抑制AXL活性的抗体，特别是单克隆抗体。
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