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    Method for the production of bacterial toxins
    3.
    发明申请
    Method for the production of bacterial toxins 失效
    生产细菌毒素的方法

    公开(公告)号：US20050100553A1

    公开(公告)日：2005-05-12

    申请号：US10677496

    申请日：2003-10-03

    申请人： Milan Blake ,  John Bogdan ,  Javier Nazario-Larrieu

    发明人： Milan Blake ,  John Bogdan ,  Javier Nazario-Larrieu

    IPC分类号： C07K14/235 ,  C12N1/20 ,  C12N9/88 ,  A61K39/02 ,  C12N1/21

    CPC分类号： C07K14/235 ,  C12N1/20 ,  C12N9/88

    摘要： Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.

    摘要翻译： 提供了用于在大规模培养物中增强细菌毒素生产的方法和组合物。 具体地，用于减少细菌毒素表达抑制剂的方法和组合物提供包括但不限于添加毒素表达抑制剂结合化合物，具有降低浓度的毒素抑制剂代谢前体的培养基和缺乏代谢毒素所需的酶的遗传修饰的产毒细菌 抑制剂代谢前体。

    Single-chip digital phase frequency synthesiser
    4.
    发明申请
    Single-chip digital phase frequency synthesiser 审中-公开
    单芯片数字相位频率合成器

    公开(公告)号：US20050212565A1

    公开(公告)日：2005-09-29

    申请号：US10498184

    申请日：2002-12-02

    申请人： John Bogdan

    发明人： John Bogdan

    IPC分类号： H03L7/07 ,  H04J3/06 ,  H03B21/00

    CPC分类号： H03L7/07 ,  H04J3/0685

    摘要： An inexpensive, reliable and high quality digital phase frequency synthesis method and circuit providing universal transmission synchronizer for wireless, optical, or wireline transmission systems and for a wide range of data rates. In particular this invention enables the transmission synchronizer to produce a variety of network element synchronization clocks fulfilling a programmable phase transfer function versus external synchronization clocks. The transmission synchronizer designed in accordance with this invention integrates comprehensive programmable reference monitoring, phase transfer processing, reference switching and protection switching functions into a single integrated circuit; based on high resolution synthesized clock generator, high resolution digital phase detectors, and efficient on chip system architecture.

    摘要翻译： 一种廉价，可靠和高质量的数字相位频率合成方法和电路，为无线，光或有线传输系统和广泛的数据速率提供通用传输同步器。 特别地，本发明使得传输同步器能够产生满足可编程相位传递函数与外部同步时钟的各种网络元件同步时钟。 根据本发明设计的传输同步器将综合可编程参考监视，相位传输处理，参考开关和保护切换功能集成到单个集成电路中; 基于高分辨率合成时钟发生器，高分辨率数字相位检测器和高效的片上系统架构。

    Noise Filtering Edge Detectors
    7.
    发明申请
    Noise Filtering Edge Detectors 审中-公开
    噪声滤波边缘检测器

    公开(公告)号：US20070160229A1

    公开(公告)日：2007-07-12

    申请号：US10597043

    申请日：2005-01-07

    申请人： John Bogdan

    发明人： John Bogdan

    IPC分类号： H04B15/00

    CPC分类号： H04L25/068

    摘要： This invention relates to a noise filtering edge detector (NFED) for recovering data carrying edges from a noisy received signal by dense over-sampling of the received signal and by detecting edge phases and edge amplitude limits wherein recovered signal amplitudes at sampling instance defining said edge phase are determined by said edge amplitude limits while recovered amplitudes assumed at sampling instances following the last edge detected are those implementing an ideal signal shape determined by the last edge. The NFED comprises a system for adaptive noise filtering which analyzes captured unfiltered portions of the over-sampled waveform in order to compensate predictable and/or random signal distortions and interferences.

    摘要翻译： 噪声滤波边缘检测器（NFED）本发明涉及噪声滤波边缘检测器（NFED），用于通过接收信号的密集过采样和通过检测边缘相位和边缘幅度极限从嘈杂接收信号中恢复数据携带边缘，其中在采样实例上限定所述边缘的恢复信号幅度 相位由所述边缘幅度极限确定，而在检测到的最后边缘之后的采样实例处假设的恢复幅度是实现由最后边缘确定的理想信号形状的那些。 NFED包括用于自适应噪声滤波的系统，其分析过采样波形的捕获的未滤波部分，以便补偿可预测和/或随机的信号失真和干扰。

    Digital signal processing of multi-sampled phase
    8.
    发明申请
    Digital signal processing of multi-sampled phase 失效
    数字信号处理多采样相位

    公开(公告)号：US20060238240A1

    公开(公告)日：2006-10-26

    申请号：US10520040

    申请日：2003-06-25

    申请人： John Bogdan

    发明人： John Bogdan

    IPC分类号： H03D3/02

    CPC分类号： H04L7/0087 ,  H04L7/0338

    摘要： The DSP MSP invention provides an implementation of programmable algorithms for analyzing a very wide range of low and high frequency wave-forms. The DSP MSP comprises a synchronous sequential processor (SSP) for real time capturing and processing of in-coming wave-form and a programmable computing unit (PCU) for controlling SSP operations and supporting adaptive signal analysis algorithms. The DSP MSP further comprises a circuit for Sequential Data Recovery from Multi Sampled Phase (SDR MSP), for a receiver of an optical waveform.

    摘要翻译： DSP MSP发明提供了用于分析非常宽范围的低频和高频波形的可编程算法的实现。 DSP MSP包括用于实时捕获和处理进入波形的同步顺序处理器（SSP）和用于控制SSP操作并支持自适应信号分析算法的可编程计算单元（PCU）。 DSP MSP还包括用于光学波形的接收机的用于从多采样相位（SDR MSP）进行顺序数据恢复的电路。