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    Surface modifying composition
    1.
    发明申请
    Surface modifying composition 审中-公开
    表面改性组合物

    公开(公告)号：US20050255582A1

    公开(公告)日：2005-11-17

    申请号：US11124022

    申请日：2005-05-06

    申请人： Milan Mrksich ,  Yan-Yeung Luk

    发明人： Milan Mrksich ,  Yan-Yeung Luk

    IPC分类号： B05D1/18 ,  C07C323/12 ,  H01L21/00 ,  C07C323/39 ,  C12M1/34

    CPC分类号： B82Y30/00 ,  B05D1/185 ,  B82Y5/00 ,  C07C323/12

    摘要： Alkanethiols of formula (1) and the enantimomers of the alkanethiol of formula (1): HS-L-Q-T  (1), and disulfides of formula (3) and the enantimomers of the disulfide of formula (3): T-Q-L-S—S-J  (3), where -T is a moiety of formula (2) R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.

    摘要翻译： 式（1）的烷基硫醇和式（1）的链烷硫醇的对映异构体：<？in-line-formula description =“In-line Formulas”end =“lead”？> HS-LQT（1），< 和式（3）的二硫化物和式（3）的二硫化物的对映体：<？in-line-formula description =“In-line-formula description =”In-line formula“end =”tail“ “公式”end =“lead”？> TQLSSJ（3），<？in-line-formula description =“In-line formula”end =“tail”？>其中-T是式（2） SUP> 1和R 2各自分别选自H和OH; a是0到3; b为0〜3; “img id =”custom-character-00001“he =”2.79mm“wi =”5.25mm“file =”US20050255582A1-20051117-P00900.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>表示其附着的碳原子的手性为R或S; 可形成惰性表面，防止蛋白质和细胞的不必要的吸附。

    Making surfaces inert by modifying with alkanethiolates
    2.
    发明授权
    Making surfaces inert by modifying with alkanethiolates 失效
    用烷基硫醇盐改性使表面呈惰性

    公开(公告)号：US06972196B1

    公开(公告)日：2005-12-06

    申请号：US09689263

    申请日：2000-10-11

    申请人： Milan Mrksich ,  Yan-Yeung Luk

    发明人： Milan Mrksich ,  Yan-Yeung Luk

    IPC分类号： B05D1/18 ,  C07C323/12 ,  C12N5/06 ,  C12N5/08 ,  C12N11/02 ,  C12N11/14 ,  C12Q1/02

    CPC分类号： B82Y30/00 ,  B05D1/185 ,  B82Y5/00 ,  C07C323/12

    摘要： Alkanethiols of formula (1) and the enantiomers of the alkanethiol of formula (1): HS-L-Q-T  (1), and disulfides of formula (3) and the enantiomers of the disulfide of formula (3): T-Q-L S-S-J  (3), where -T is a moiety of formula (2) R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.

    摘要翻译： 式（1）的烷基硫醇和式（1）的链烷硫醇的对映异构体：<？in-line-formula description =“In-line formula”end =“lead”？> HS-LQT（1），< 式（3）的二硫化物和式（3）的二硫化物的对映异构体：<？in-line-formula description =“In-line-formula description =”In-line formula“end =”tail“ “公式”end =“lead”？> TQL SSJ（3），<？in-line-formula description =“In-line Formulas”end =“tail”？>其中-T是式（2）的部分R H 1和R 2各自独立地选自H和OH; a是0到3; b为0〜3; “img id =”CUSTOM-CHARACTER-00001“he =”2.46mm“wi =”5.67mm“file =”US06972196-20051206-P00900.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>表示其附着的碳原子的手性为R或S; 可形成惰性表面，防止蛋白质和细胞的不必要的吸附。

    SYSTEM AND METHOD FOR CONTROLLING GROWTH OF MICROORGANISMS WITH BROMINATED FURANONES
    3.
    发明申请
    SYSTEM AND METHOD FOR CONTROLLING GROWTH OF MICROORGANISMS WITH BROMINATED FURANONES 有权
    用于控制微生物生长的系统和方法

    公开(公告)号：US20120264950A1

    公开(公告)日：2012-10-18

    申请号：US13529411

    申请日：2012-06-21

    申请人： Yan-Yeung Luk ,  Dacheng Ren

    发明人： Yan-Yeung Luk ,  Dacheng Ren

    IPC分类号： C07D305/12

    CPC分类号： A01N43/08

    摘要： A method for inhibiting the growth of a microorganism using an effective amount of one or more of the following synthetic brominated furanones: (i) 4-bromo-5Z-(bromomethylene)-3-methylfuran-2-one; (ii) 3-(dibromomethyl)-5-(dibromomethylene)furan-2-one; (iii) 3-(bromomethyl)-5-(dibromomethylene)furan-2-one; (iv) 4-bromo-3-(bromomethyl)-5Z-(bromomethylene)furan-2-one; or (v) 4-bromo-5-(dibromomethyl)-3-methylfuran-2(5H)-one. The brominated furanones inhibit the growth of both fungi and bacteria, including the fungal species Candida albicans, Gloeophyllum trabeum, Chaetomium globosum, and Trametes versicolor and the bacterial species Pseudomonas aeruginosa. The brominated furanones can be used topically or internally to treat human infections, and can be used to treat other objects, such as wood building supplies, to prevent fungal rot.

    摘要翻译： 使用有效量的一种或多种以下合成溴化呋喃酮抑制微生物生长的方法：（i）4-溴-5Z-（溴亚甲基）-3-甲基呋喃-2-酮; （ii）3-（二溴甲基）-5-（二溴亚甲基）呋喃-2-酮; （iii）3-（溴甲基）-5-（二溴亚甲基）呋喃-2-酮; （ⅳ）4-溴-3-（溴甲基）-5Z-（溴亚甲基）呋喃-2-酮; 或（v）4-溴-5-（二溴甲基）-3-甲基呋喃-2（5H） - 酮。 溴化呋喃酮抑制真菌和细菌的生长，包括真菌种白色念珠菌，小叶绿脓杆菌，球状芽孢杆菌和多花紫色和细菌种绿脓假单胞菌（Pseudomonas aeruginosa）。 溴化呋喃酮可以局部或内部用于治疗人类感染，并可用于治疗其他物体，如木材建筑用品，以防止霉菌腐烂。

    Squarylated Lactones Inhibitors for Bacterial Biofilm Formation
    6.
    发明申请
    Squarylated Lactones Inhibitors for Bacterial Biofilm Formation 有权
    用于细菌生物膜形成的Squarylated内酯抑制剂

    公开(公告)号：US20140039195A1

    公开(公告)日：2014-02-06

    申请号：US13957038

    申请日：2013-08-01

    申请人： Yan-Yeung Luk ,  Sri Kamesh Narasimhan ,  Eric Falcone

    发明人： Yan-Yeung Luk ,  Sri Kamesh Narasimhan ,  Eric Falcone

    IPC分类号： C07D307/20 ,  C07D405/12 ,  C07D409/12

    CPC分类号： C07D307/20 ,  C07D307/32 ,  C07D405/12 ,  C07D409/12

    摘要： A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 μM), these small molecules inhibit biofilm formation of E. coli. Moreover, these compounds are not toxic up to 300 μM and do not significantly attenuate E. coli growth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (˜50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.

    摘要翻译： 一种非天然的正方体高丝氨酸内酯（SHL）和squarylated内酯的文库，其具有调节革兰氏阴性细菌生物膜形成的潜力。 在低浓度（约200μM）下，这些小分子抑制大肠杆菌的生物膜形成。 此外，这些化合物至多300μM没有毒性，并且不显着减弱大肠杆菌的生长。 SHL具有分散已知生物膜的潜力，并且在生物膜生长期间通过使用SHL显示出最大生物膜厚度的降低（约50％）。

    METHOD OF COVALENTLY MODIFYING PROTEINS WITH ORGANIC MOLECULES TO PREVENT AGGREGATION
    8.
    发明申请
    METHOD OF COVALENTLY MODIFYING PROTEINS WITH ORGANIC MOLECULES TO PREVENT AGGREGATION 有权
    共同修饰蛋白质与有机分子的方法，以防止聚集

    公开(公告)号：US20100273991A1

    公开(公告)日：2010-10-28

    申请号：US12766063

    申请日：2010-04-23

    申请人： Yan-Yeung Luk ,  DaWei Cui ,  Debjyoti Bandyopadhyay ,  Deepali Prashar ,  Preeti Sejwal ,  Karen Simon

    发明人： Yan-Yeung Luk ,  DaWei Cui ,  Debjyoti Bandyopadhyay ,  Deepali Prashar ,  Preeti Sejwal ,  Karen Simon

    IPC分类号： C07K16/00 ,  C07K1/107 ,  C07K14/00

    CPC分类号： C07K1/1077 ,  A61K38/00 ,  A61K39/39591 ,  A61K41/0004 ,  C07K1/006 ,  C07K1/13

    摘要： A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved.

    摘要翻译： 用蛋白质共价修饰可以保护天然蛋白质折叠的有机分子来发展蛋白质聚集的系统和方法。 通过水驱动的生物有机反应，蛋白质与糖醇或环糊精（有机Kosmotropes）或其他小分子药物共价修饰。 在水驱动的生物有机反应中，试剂在水中稳定，可以在生理条件下以高产率和快速率调节蛋白质的赖氨酸残基或半胱氨酸残基。 蛋白质和抗体将被非天然糖醇修饰。 结果，可以提高蛋白质药物的功效（聚集和酶降解降低，血流寿命增加）。