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公开(公告)号：US06584013B2
公开(公告)日：2003-06-24
申请号：US09982792
申请日：2001-10-22
IPC分类号： G11C1134
CPC分类号： G11C11/005
摘要： A dynamic-type memory A, a non-volatile memory B and a static-type memory C are enclosed in one package. Separated from a first terminal supplying a power-supply potential to the memories A and B, a second terminal supplying a power-supply potential to the memory C is provided. By stopping the supply of the power-supply potential to the first terminal at stand-by, stand-by current of a semiconductor memory device can be reduced. Therefore, the semiconductor memory device having an increased memory capacity while reducing a mounting area and consumption current at stand-by can be provided.
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公开(公告)号：US06697910B2
公开(公告)日：2004-02-24
申请号：US09987895
申请日：2001-11-16
IPC分类号： G06F1200
CPC分类号： G11C11/406
摘要： In a semiconductor memory device, a refresh circuit outputs a refresh command signal for executing refresh operation. The refresh circuit includes a command-signal activating circuit for activating the refresh command signal, and a determination circuit for determining whether the activated refresh command signal is to be output. The determination circuit determines that the activated refresh command signal is to be output when the semiconductor memory device is in a standby state. Thereby, the semiconductor memory device enables stable refresh operation to be executed.
摘要翻译： 在半导体存储器件中，刷新电路输出用于执行刷新操作的刷新命令信号。 刷新电路包括用于激活刷新命令信号的命令信号激活电路，以及用于确定是否输出激活的刷新命令信号的确定电路。 确定电路确定当半导体存储器件处于待机状态时，输出激活的刷新命令信号。 因此，半导体存储器件能够执行稳定的刷新操作。
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公开(公告)号：US06577553B2
公开(公告)日：2003-06-10
申请号：US10123167
申请日：2002-04-17
申请人： Ryu Makabe , Masaki Tsukude , Hirotoshi Sato , Shinichi Kobayashi
发明人： Ryu Makabe , Masaki Tsukude , Hirotoshi Sato , Shinichi Kobayashi
IPC分类号： G11C800
CPC分类号： G11C7/1045 , G11C7/1078 , G11C7/22 , G11C11/406 , G11C11/40615 , G11C11/40618 , G11C11/40622 , G11C11/4093 , G11C2207/2227
摘要： Successive data read access with a final address specified is detected by a command mode detecting circuit to set a command mode entry status. In the command mode entry, a command of designating an internal state is made acceptable in accordance with a predetermined external signal. Consequently, a semiconductor memory device that enters a command mode, maintaining compatibility of pins and signal timings with a conventional static memory is provided.
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公开(公告)号：USRE41245E1
公开(公告)日：2010-04-20
申请号：US11148452
申请日：2005-06-09
申请人： Ryu Makabe , Masaki Tsukude , Hirotoshi Sato , Shinichi Kobayashi
发明人： Ryu Makabe , Masaki Tsukude , Hirotoshi Sato , Shinichi Kobayashi
IPC分类号： G11C8/00
CPC分类号： G11C7/1045 , G11C7/1078 , G11C7/22 , G11C11/406 , G11C11/40615 , G11C11/40618 , G11C11/40622 , G11C11/4093 , G11C2207/2227
摘要： Successive data read access with a final address specified is detected by a command mode detecting circuit to set a command mode entry status. In the command mode entry, a command of designating an internal state is made acceptable in accordance with a predetermined external signal. Consequently, a semiconductor memory device that enters a command mode, maintaining compatibility of pins and signal timings with a conventional status memory is provided.
摘要翻译： 通过命令模式检测电路检测指定的最终地址的连续数据读取访问以设置命令模式输入状态。 在命令模式输入中，根据预定的外部信号使指定内部状态的命令成为可接受的命令。 因此，提供了进入指令模式，保持引脚和信号定时与常规状态存储器的兼容性的半导体存储器件。
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公开(公告)号：US06434065B1
公开(公告)日：2002-08-13
申请号：US09911729
申请日：2001-07-25
申请人： Shinichi Kobayashi , Masaki Tsukude
发明人： Shinichi Kobayashi , Masaki Tsukude
IPC分类号： G11C700
CPC分类号： G11C29/83 , G11C7/12 , G11C29/02 , G11C2207/2227
摘要： In order to change the precharging voltage level when the bit lines are in the floating state, current control circuits are provided for restricting a current supply amount to the bit lines in the standby state, for example. Data, of which the logic level is fixed, are read out, in the existence of a leak current, due to a change of the bit line voltage caused by this leak current and thereby, the existence of a minute leak current can be detected. Consequently, a semiconductor memory device with an extremely low standby current is implemented by precisely detecting a minute leak current of the bit lines and by repairing the leak current defect.
摘要翻译： 为了在位线处于浮置状态时改变预充电电压电平，例如提供电流控制电路用于限制待机状态下的位线的电流供给量。 由于漏电流引起的位线电压的变化，在存在漏电流的情况下，读出固定有逻辑电平的数据，从而可以检测出微小漏电流的存在。 因此，具有极低待机电流的半导体存储器件通过精确检测位线的微小泄漏电流并修复泄漏电流缺陷来实现。
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公开(公告)号：US09273128B2
公开(公告)日：2016-03-01
申请号：US14236793
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段 和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。
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公开(公告)号：US09180188B2
公开(公告)日：2015-11-10
申请号：US14236795
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译： 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。
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公开(公告)号：US08985387B2
公开(公告)日：2015-03-24
申请号：US13253729
申请日：2011-10-05
申请人： Shinichi Kobayashi
发明人： Shinichi Kobayashi
CPC分类号： B65D83/0829 , A45C11/182
摘要： In order to provide a card case in which cards can be automatically and promptly discharged one by one, the case has a case body capable of accommodating more than one cards inside, a card discharging plate mounted so as to proceed from and retreat into the case body via a card discharging opening provided on a side portion of the case body, with a card being placed on its upper surface, and an elastic piece for movably urging the card discharging plate in one direction.
摘要翻译： 为了提供卡片可以一个一个地自动且及时地排出的卡片盒，该壳体具有能够容纳多于一个卡片的盒体，安装在其上的卡片放出板，以便从壳体 通过设置在壳体的侧部上的卡片排出口，具有放置在其上表面上的卡片以及用于沿一个方向可移动地推动卡片排出板的弹性件。
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9.发明授权Head-mounted display device and control method for the head-mounted display device 有权头戴显示装置的头戴显示装置和控制方法公开(公告)号：US08896500B2
公开(公告)日：2014-11-25
申请号：US13353731
申请日：2012-01-19
申请人： Shinichi Kobayashi
发明人： Shinichi Kobayashi
CPC分类号： G02B27/017 , G02B2027/014 , G02B2027/0178 , G09G3/003 , G09G3/3406 , G09G2310/0237
摘要： A head-mounted display device that is mounted on the head of an observer and forms a virtual image before the eyes of the observer includes: a display device that forms an image, which is the source of image light, from image data; a light source that emits the image light representing the formed image; a light guide unit that forms a virtual image from the emitted image light; and a display control unit that turns off the light source and changes the head-mounted display device to a suspension mode when a suspension request is received from the outside.
摘要翻译： 安装在观察者的头部并在观察者的眼睛之前形成虚拟图像的头戴式显示装置包括：从图像数据形成作为图像光源的图像的显示装置; 发出表示形成图像的图像光的光源; 导光单元，其从所发射的图像光形成虚拟图像; 以及显示控制单元，当从外部接收到暂停请求时，关闭光源并将头戴式显示设备改变为暂停模式。
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公开(公告)号：US20140178373A1
公开(公告)日：2014-06-26
申请号：US14236665
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6865 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
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