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    Stable plurilamellar vesicles
    4.
    发明授权
    Stable plurilamellar vesicles 失效
    稳定的多层囊泡

    公开(公告)号：US5169637A

    公开(公告)日：1992-12-08

    申请号：US679569

    申请日：1991-04-02

    申请人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    发明人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1277

    摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

    摘要翻译： 描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包裹含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的排出。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

    Stable plurilamellar vesicles
    5.
    发明授权
    Stable plurilamellar vesicles 失效
    稳定的多层囊泡

    公开(公告)号：US5030453A

    公开(公告)日：1991-07-09

    申请号：US660573

    申请日：1984-10-12

    申请人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    发明人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1277 ,  A61K9/127

    摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

    摘要翻译： 描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包围含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的浓度。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

    Liposome composition for lupus assay
    10.
    发明授权
    Liposome composition for lupus assay 失效
    用于狼疮检测的脂质体组成

    公开(公告)号：US4668638A

    公开(公告)日：1987-05-26

    申请号：US535884

    申请日：1983-09-26

    申请人： Andrew S. Janoff ,  Marc J. Ostro ,  Alan L. Weiner ,  Gerald Weissmann ,  James R. Seibold

    发明人： Andrew S. Janoff ,  Marc J. Ostro ,  Alan L. Weiner ,  Gerald Weissmann ,  James R. Seibold

    IPC分类号： G01N33/544 ,  A61K39/00 ,  G01N33/554 ,  G01N33/564 ,  B32B5/16 ,  B32B9/02 ,  B32B9/04

    CPC分类号： G01N33/554 ,  G01N33/564 ,  G01N2800/104 ,  Y10S436/829 ,  Y10T428/2984

    摘要： An immunoassay utilizing a novel liposome composition in which there is incorporated a stabilizing or destabilizing component and an antigen. The presence of cognate antibodies in test samples is detected by the alteration of the supramolecular structure of the liposomes resulting in changes in stabilization. Destabilization can be detected, and in certain cases, caused by, the addition of magnesium or calcium ions. Increased stabilization can be detected by the polymerization of bilayer components in response to ultraviolet light. Antibody-antigen interactions at the liposome surface mediate the stabilization/destabilization response.

    摘要翻译： 使用新型脂质体组合物的免疫测定法，其中引入了稳定化或去稳定化组分和抗原。 通过改变脂质体的超分子结构来检测测试样品中同源抗体的存在，导致稳定性的变化。 可以检测到不稳定，并且在某些情况下，由添加镁或钙离子引起。 通过响应于紫外光的双层组分的聚合可以检测到增加的稳定性。 脂质体表面的抗体 - 抗原相互作用介导稳定/不稳定反应。