-
公开(公告)号：US5059591A
公开(公告)日：1991-10-22
申请号：US405623
申请日：1989-09-12
申请人： Andrew S. Janoff , Mircea C. Popescu , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Paul A. Tremblay , Alan L. Weiner
发明人： Andrew S. Janoff , Mircea C. Popescu , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Paul A. Tremblay , Alan L. Weiner
CPC分类号： A61K47/48215 , A61K47/48053 , A61K47/48123 , A61K9/127
摘要： Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.
摘要翻译： 描述了与某些配体混合的药物的制备，其当施用于动物或人时比常规药物制剂毒性低。 虽然所述药物 - 配体制剂的毒性大大降低，但药物保留药理活性。
-
公开(公告)号：US4897384A
公开(公告)日：1990-01-30
申请号：US844248
申请日：1986-03-24
申请人： Andrew S. Janoff , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Mircea C. Popescu , Paul A. Tremblay , Alan L. Weiner
发明人： Andrew S. Janoff , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Mircea C. Popescu , Paul A. Tremblay , Alan L. Weiner
IPC分类号： A61K20060101 , A61K9/127 , A61K31/00 , A61K31/66 , A61K31/665 , A61K31/70 , A61K47/00 , A61K47/48
CPC分类号： A61K9/127 , A61K47/48053 , A61K47/48123 , A61K47/48215
摘要： Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.
摘要翻译： 描述了与某些配体混合的药物的制备，其当施用于动物或人时比常规药物制剂毒性低。 虽然所述药物 - 配体制剂的毒性大大降低，但药物保留药理活性。
-
公开(公告)号：US5154930A
公开(公告)日：1992-10-13
申请号：US160141
申请日：1988-02-25
申请人： Mircea C. Popescu , Paul A. Tremblay , Andrew S. Janoff , Marc J. Ostro , Elaine Chan , Alan Weiner
发明人： Mircea C. Popescu , Paul A. Tremblay , Andrew S. Janoff , Marc J. Ostro , Elaine Chan , Alan Weiner
CPC分类号： B82Y5/00 , A61K47/10 , A61K47/24 , A61K9/0019 , A61K9/1277 , A61K9/4858 , Y10S436/829 , Y10S514/885 , Y10S514/937 , Y10T428/2984
摘要： A pharmacological agent-lipid solution preparation comprising a lipophilic pharmacological agent, a desalted charged lipid and an aqueous-miscible lipid solvent such that upon introduction into an aqueous medium a suspension of lipid aggregates associated with the pharmacological agent are formed, and methods of manufacture and use.
摘要翻译： 一种药理学试剂 - 脂溶液制剂，其包含亲脂性药理学试剂，脱盐的带电脂质和水溶性脂溶性溶剂，使得在引入水性介质中形成与药理学试剂相关的脂质聚集体的悬浮液时， 使用。
-
公开(公告)号：US4891208A
公开(公告)日：1990-01-02
申请号：US773429
申请日：1985-09-10
申请人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolscak , Paul A. Tremblay , Christine E. Swenson
发明人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolscak , Paul A. Tremblay , Christine E. Swenson
IPC分类号： A61K38/00 , A23K20060101 , A23K1/00 , A61K20060101 , A61K9/00 , A61K9/02 , A61K9/06 , A61K9/10 , A61K9/107 , A61K9/127 , A61K9/52 , A61K31/00 , A61K31/415 , A61K38/22 , A61K39/00 , A61K39/395 , A61K47/00 , A61K47/28 , A61K49/00 , A61K51/00 , A61P31/04 , B01J20060101 , B01J13/00 , B01J13/02
CPC分类号： A61K9/1271 , A61K9/1272 , A61K2039/55555 , Y10S436/829 , Y10S514/885 , Y10S514/887 , Y10S514/967 , Y10T428/2984
摘要： Steroidal liposomes comprising a bioactive agent and method for their administration are disclosed, the bilayers of said steroidal liposomes comprising a salt form of a carboxylic acid derivative of a sterol, a salt form of a polycarboxylic acid derivative of a sterol, a salt form of a hydroxy carboxylic acid derivative of a sterol, a salt form of an amino acid derivative of a sterol or a salt form of a poly (amino acid) derivative of a sterol; or a salt form of an organic acid derivative of cholesterol, a vitamin D, a phytosterol, or a steroidal hormone.
摘要翻译： 公开了包含生物活性剂和其给药方法的类固醇脂质体，所述甾族脂质体的双层包含固醇的羧酸衍生物的盐形式，固醇的多元羧酸衍生物的盐形式， 固醇的羟基羧酸衍生物，固醇的氨基酸衍生物的盐形式或固醇的聚（氨基酸）衍生物的盐形式; 或胆固醇，维生素D，植物甾醇或类固醇激素的有机酸衍生物的盐形式。
-
公开(公告)号：US5288499A
公开(公告)日：1994-02-22
申请号：US758587
申请日：1991-09-12
申请人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolcsak , Paul A. Tremblay , Christine E. Swenson
发明人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolcsak , Paul A. Tremblay , Christine E. Swenson
CPC分类号： A61K9/1271 , A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/02 , A61K9/12 , A61K9/1272 , C12N15/88 , A61K2039/55555 , A61K47/12 , A61K47/28 , Y10S424/15 , Y10S436/829 , Y10S514/887 , Y10S514/967 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such as the tris-salt form of a sterol hemisuccinate, and to compositions comprising a mixture of tris(hydroxymethyl)aminomethane salt of cholesteryl hemisuccinate with either an antifungal compound or a peptide. These compositions have various applications in vivo.
摘要翻译： 描述了用于制备包含在脂质囊泡中的生物活性剂的方法和组合物，其双层包含固醇类的有机酸衍生物的盐形式，例如三羟甲基半琥珀酸酯的三盐形式，以及包含混合物 胆固醇半琥珀酸盐的三（羟甲基）氨基甲烷盐与抗真菌化合物或肽。 这些组合物在体内具有各种应用。
-
6.发明授权Compositions containing tris salt of cholesterol hemisuccinate and antifungal 失效含有胆固醇半琥珀酸三钠盐和抗真菌剂的组合物
公开(公告)号：US5231112A
公开(公告)日：1993-07-27
申请号：US425727
申请日：1989-10-23
申请人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolcsak , Paul A. Tremblay , Christine E. Swenson
发明人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolcsak , Paul A. Tremblay , Christine E. Swenson
CPC分类号： A61K9/1271 , A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/02 , A61K9/12 , A61K9/1272 , C12N15/88 , A61K2039/55555 , A61K47/12 , A61K47/28 , Y10S424/15 , Y10S436/829 , Y10S514/887 , Y10S514/967 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such as the tris-salt form of a sterol hemisuccinate, and to bompositions comprising a mixture of tris(hydroxymethyl)aminomethane salt of cholesteryl hemisuccinate with either an antifungal compound or a peptide. These compositions have various applications in vivo.
摘要翻译： 描述了用于制备包埋在脂质囊泡中的生物活性剂的方法和组合物，其双层包含固醇的有机酸衍生物的盐形式，例如三羟甲基半琥珀酸盐的三盐形式，以及包含混合物 胆固醇半琥珀酸盐的三（羟甲基）氨基甲烷盐与抗真菌化合物或肽。 这些组合物在体内具有各种应用。
-
公开(公告)号：US06352716B1
公开(公告)日：2002-03-05
申请号：US08108822
申请日：1993-08-18
申请人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolcsak , Paul A. Tremblay , Christine E. Swenson
发明人： Andrew S. Janoff , Mircea C. Popescu , Alan L. Weiner , Lois E. Bolcsak , Paul A. Tremblay , Christine E. Swenson
IPC分类号： A61K9127
CPC分类号： A61K9/1271 , A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/02 , A61K9/12 , A61K9/1272 , A61K47/12 , A61K47/28 , A61K2039/55555 , C12N15/88 , Y10S424/15 , Y10S436/829 , Y10S514/887 , Y10S514/967 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such as the tris-salt form of a sterol hemisuccinate, and to bompositions comprising a mixtue of tris(hydroxymethyl)aminomethane salt of cholesteryl hemisuccinate with either an antifungal compound or a peptide. These compositions have various applications in vivo.
摘要翻译： 描述了用于制备包含在脂质囊泡中的生物活性剂的方法和组合物，其双层包含固醇的有机酸衍生物的盐形式，例如半琥珀酸固醇的三盐形式，以及包含混合物 胆固醇半琥珀酸盐的三（羟甲基）氨基甲烷盐与抗真菌化合物或肽。 这些组合物在体内具有各种应用。
-
8.发明授权Composition using salt form of organic acid derivative of alpha-tocopheral 失效使用盐形式的α-生育酚的有机酸衍生物的组合物
公开(公告)号：US4861580A
公开(公告)日：1989-08-29
申请号：US911138
申请日：1986-09-24
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
IPC分类号： A61K9/127 , A61K31/355 , A61K38/00 , A61K45/00 , A61K47/22 , A61K47/28 , A61P25/00 , A61P25/04 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/10 , A61P37/06
CPC分类号： A61K9/1277 , A61K31/355 , A61K9/1272 , Y10S436/829 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
摘要翻译： 描述了用于制备α-生育酚囊泡的方法和组合物，其双层包含α-生育酚的有机酸衍生物的盐形式，例如α-生育酚半琥珀酸盐的三盐盐形式。 该方法快速有效，不需要使用有机溶剂。 α-生育酚囊泡可用于捕获不溶于水溶液的化合物。 这种制剂对于捕获有限溶解度的生物活性剂特别有用，因此能够在体内施用。
-
9.发明授权
公开(公告)号：US5330689A
公开(公告)日：1994-07-19
申请号：US39941
申请日：1993-03-29
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
IPC分类号： A61K9/127 , A61K9/133 , A61K31/355
CPC分类号： A61K9/1272 , A61K31/355 , A61K9/1277 , Y10S436/829 , Y10S514/885 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
摘要翻译： 描述了用于制备α-生育酚囊泡的方法和组合物，其双层包含α-生育酚的有机酸衍生物的盐形式，例如α-生育酚半琥珀酸盐的三盐盐形式。 该方法快速有效，不需要使用有机溶剂。 α-生育酚囊泡可用于捕获不溶于水溶液的化合物。 这种制剂对于捕获有限溶解度的生物活性剂特别有用，因此能够在体内施用。
-
公开(公告)号：US5234634A
公开(公告)日：1993-08-10
申请号：US599290
申请日：1990-10-17
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini
IPC分类号： A61K9/127 , A61K9/133 , A61K31/355
CPC分类号： A61K9/1272 , A61K31/355 , A61K9/1277 , Y10S436/829 , Y10S514/885 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.039 秒)
