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21 条记录 (耗时 0.053 秒)

    Stable plurilamellar vesicles
    3.
    发明授权
    Stable plurilamellar vesicles 失效
    稳定的多层囊泡

    公开(公告)号：US5169637A

    公开(公告)日：1992-12-08

    申请号：US679569

    申请日：1991-04-02

    申请人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    发明人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1277

    摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

    摘要翻译： 描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包裹含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的排出。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

    Stable plurilamellar vesicles
    4.
    发明授权
    Stable plurilamellar vesicles 失效
    稳定的多层囊泡

    公开(公告)号：US5030453A

    公开(公告)日：1991-07-09

    申请号：US660573

    申请日：1984-10-12

    申请人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    发明人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1277 ,  A61K9/127

    摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

    摘要翻译： 描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包围含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的浓度。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

    Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
    5.
    发明授权
    Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use 失效
    含肽的脂质体，免疫原性脂质体及其制备和使用方法

    公开(公告)号：US5916588A

    公开(公告)日：1999-06-29

    申请号：US452549

    申请日：1995-05-25

    申请人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    发明人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K39/39 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K9/1271 ,  A61K2039/55555

    摘要： A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use.Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.

    摘要翻译： 包含至少一种稳定脂质和至少一种与脂质体相关的肽样治疗剂的高完整性脂质体，其适于肠胃外给予动物，包括人类，以及根据制造和使用的方法。 包含脂质体和免疫原的免疫剂型，其中所述脂质体和免疫原以免疫剂量存在。 此外，包含特定适于产生免疫应答的形式的剂型，其包含根据固醇和免疫原的有机酸衍生物的盐，其以免疫剂量存在，并且公开了根据用途的方法。 此外，包括特别适于产生免疫应答的剂型，包括任选在氢氧化铝凝胶中的二肉豆蔻基磷脂酰胆碱（DMPC）/胆固醇脂质体和免疫原，其中DMPC /胆固醇和免疫原以免疫剂量存在， 和方法根据用途。

    Potentiation of immune responses with liposomal adjuvants
    6.
    发明授权
    Potentiation of immune responses with liposomal adjuvants 失效
    用脂质体佐剂增强免疫反应

    公开(公告)号：US6090406A

    公开(公告)日：2000-07-18

    申请号：US485388

    申请日：1990-02-26

    申请人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    发明人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K39/12 ,  A61K39/385 ,  B01J13/02

    CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K2039/55555 ,  Y10S424/812

    摘要： A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.

    摘要翻译： 包含至少一种稳定脂质和与所述脂质体相关联的至少一种肽样治疗剂的高完整性脂质体，适于肠胃外给予动物（包括人），以及根据制造和使用的方法。 包含脂质体和免疫原的免疫剂型，其中所述脂质体和免疫原以免疫剂量存在。 另外，包括特别适于产生免疫应答的剂型，其包含根据固醇和免疫原的有机酸衍生物的盐，其中所述固醇和免疫原的所述有机酸衍生物以免疫剂量存在，以及 公开了根据使用的方法。 此外，包括特别适于产生免疫应答的形式的剂型，包括二肉豆蔻酰磷脂酰胆碱（DMPC）/胆固醇脂质体，任选地在氢氧化铝凝胶中，以及免疫原，其中所述DMPC /胆固醇和免疫原以免疫剂量存在， 和方法根据用途。