专利检索 cpc:"C07C327/46" 第 1 页

1.

发明申请
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO 有权

公开(公告)号：US20160044925A1

公开(公告)日：2016-02-18

申请号：US14880782

申请日：2015-10-12

申请人： Dow AgroSciences LLC

发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa

IPC分类号： A01N47/32 , A01N43/40 , C07D207/27 , A01N43/36 , C07D331/04 , A01N43/20 , C07D277/30 , A01N43/78 , C07D239/26 , A01N43/54 , C07D307/16 , A01N37/10 , A01N43/08 , C07D277/64 , C07D241/12 , A01N43/60 , C07D233/64 , A01N43/50 , C07D309/14 , A01N43/16 , C07D271/10 , C07C255/57 , A01N43/82 , C07D211/58 , C07D209/50 , A01N43/38 , A01N37/34 , C07D249/08 , A01N43/653 , A01N25/08 , A01N37/18 , C07D295/192 , A01N43/84 , C07D213/61 , C07C335/14 , C07C233/59 , C07D237/32 , A01N43/58 , C07C211/29 , A01N33/04 , C07D401/10 , C07C63/70

CPC分类号： C07D405/04 , A01N25/08 , A01N33/04 , A01N37/10 , A01N37/18 , A01N37/28 , A01N37/32 , A01N37/34 , A01N37/36 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , A01N43/84 , A01N47/18 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , A01N53/00 , C07C63/70 , C07C63/74 , C07C211/27 , C07C211/29 , C07C211/42 , C07C233/13 , C07C233/14 , C07C233/56 , C07C233/59 , C07C233/65 , C07C233/66 , C07C233/76 , C07C233/83 , C07C235/80 , C07C237/06 , C07C237/22 , C07C243/34 , C07C243/36 , C07C243/38 , C07C255/57 , C07C255/58 , C07C259/06 , C07C259/08 , C07C271/14 , C07C275/24 , C07C317/32 , C07C317/44 , C07C323/59 , C07C323/60 , C07C323/62 , C07C323/63 , C07C327/42 , C07C327/46 , C07C327/48 , C07C335/12 , C07C335/14 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/48 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/74 , C07D213/75 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/10 , C07D249/14 , C07D271/10 , C07D277/30 , C07D277/32 , C07D277/64 , C07D295/073 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10

摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

2.

发明授权
Pesticidal compositions and processes related thereto 有权

公开(公告)号：US09226501B2

公开(公告)日：2016-01-05

申请号：US14133094

申请日：2013-12-18

申请人： Dow AgroSciences LLC

发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa

IPC分类号： A01N53/00 , A01N43/00 , A01N43/653 , A01N43/54 , A01N47/32 , A01N43/58 , A01N43/84 , A01N43/78 , A01N37/10 , A01N37/18 , A01N37/34 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/60 , A01N43/82 , C07C233/65 , C07C233/66 , C07C255/57 , C07C63/70 , C07D207/16 , C07D213/61 , C07D295/192 , C07D331/04 , C07D401/10 , C07C259/06 , C07C259/08 , C07C271/14 , C07C275/24 , C07C211/27 , C07C211/42 , C07C233/13 , C07C233/14 , C07C233/56 , C07C233/59 , C07C233/76 , C07C233/83 , C07C237/22 , C07C243/36 , C07C243/38 , C07C317/44 , C07C323/60 , C07C323/62 , C07C327/42 , C07C327/46 , C07C327/48 , C07C335/12 , C07C335/14 , A01N33/04 , A01N37/28 , A01N37/32 , A01N37/46 , A01N41/10 , A01N43/38 , A01N47/18 , A01N47/36 , A01N47/38

CPC分类号： C07D405/04 , A01N25/08 , A01N33/04 , A01N37/10 , A01N37/18 , A01N37/28 , A01N37/32 , A01N37/34 , A01N37/36 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , A01N43/84 , A01N47/18 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , A01N53/00 , C07C63/70 , C07C63/74 , C07C211/27 , C07C211/29 , C07C211/42 , C07C233/13 , C07C233/14 , C07C233/56 , C07C233/59 , C07C233/65 , C07C233/66 , C07C233/76 , C07C233/83 , C07C235/80 , C07C237/06 , C07C237/22 , C07C243/34 , C07C243/36 , C07C243/38 , C07C255/57 , C07C255/58 , C07C259/06 , C07C259/08 , C07C271/14 , C07C275/24 , C07C317/32 , C07C317/44 , C07C323/59 , C07C323/60 , C07C323/62 , C07C323/63 , C07C327/42 , C07C327/46 , C07C327/48 , C07C335/12 , C07C335/14 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/48 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/74 , C07D213/75 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/10 , C07D249/14 , C07D271/10 , C07D277/30 , C07D277/32 , C07D277/64 , C07D295/073 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10

摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

3.

发明授权
Amide derivatives and medicinal use thereof 失效
标题翻译：酰胺衍生物及其药用

公开(公告)号：US08198454B2

公开(公告)日：2012-06-12

申请号：US12458095

申请日：2009-06-30

申请人： Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh

发明人： Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh

IPC分类号： C07D401/00 , A61K31/44

CPC分类号： C07D213/40 , C07C233/59 , C07C233/60 , C07C233/62 , C07C235/40 , C07C255/29 , C07C255/60 , C07C317/32 , C07C317/40 , C07C323/40 , C07C327/46 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/74 , C07D213/75 , C07D215/50 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D295/13 , C07D295/135 , C07D295/185 , C07D309/12 , C07D311/04 , C07D311/66 , C07D317/58 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/36 , C07D335/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04

摘要： The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.

摘要翻译： 本发明涉及具有C5a受体拮抗作用的式（1）的酰胺衍生物，其中每个符号如说明书中所定义。上述酰胺衍生物，其光学活性形式和其药学上可接受的盐有望用作治疗或预防由C5a引起的炎症引起的疾病或综合征的药物[例如，自身免疫疾病如风湿病，系统性红斑狼疮败血症，成人呼吸窘迫综合征，慢性阻塞性肺病，哮喘等过敏性疾病，动脉粥样硬化，心肌梗死，脑梗塞，牛皮癣，阿尔茨海默病和严重器官损伤（例如肺炎，肾炎，肝炎和胰腺炎等）由于由缺血再灌注，创伤，烧伤，手术入侵等引起的白细胞的活化]。此外，它们可用作由通过C5a受体侵入的细菌和病毒引起的感染性疾病的治疗或预防剂。

4.

发明授权
Diphenyl heterocyclic thioamide derivatives 失效
标题翻译：二苯基杂环硫代酰胺衍生物

公开(公告)号：US06426348B1

公开(公告)日：2002-07-30

申请号：US09864032

申请日：2001-05-23

申请人： Kenneth Gregory Hull , Achytharao Sidduri , Jefferson Wright Tilley

发明人： Kenneth Gregory Hull , Achytharao Sidduri , Jefferson Wright Tilley

IPC分类号： A61K31505

CPC分类号： C07D213/82 , C07C327/46 , C07C327/48 , C07C2601/04 , C07C2601/08 , C07D213/56 , C07D233/38 , C07D239/28 , C07D401/06

摘要： It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).

摘要翻译： 已经发现下式的化合物及其药学上可接受的盐和酯，其中X和Y如下所定义，抑制VCAM-1与VLA-4的结合，并且可用于治疗与慢性炎性疾病相关的炎症，例如作为类风湿性关节炎（RA），多发性硬化，（MS），哮喘和炎症性肠病（I BD）。

5.

发明申请
Heterocyclic thioamide derivatives 失效
标题翻译：杂环硫代酰胺衍生物

公开(公告)号：US20020052508A1

公开(公告)日：2002-05-02

申请号：US09864104

申请日：2001-05-23

发明人： Kenneth G. Hull , Achytharao Sidduri , Jefferson W. Tilley

IPC分类号： C07D213/56

CPC分类号： C07D213/82 , C07C327/46 , C07C327/48 , C07C2601/04 , C07C2601/08 , C07D213/56 , C07D233/38 , C07D239/28 , C07D401/06

摘要： It has been discovered that compounds of the formula: 1 and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (IBD).

摘要翻译： 已经发现下式的化合物及其药学上可接受的盐和酯，其中X和Y如下所定义，抑制VCAM-1与VLA-4的结合，并且可用于治疗与慢性炎性疾病相关的炎症，例如作为类风湿性关节炎（RA），多发性硬化，（MS），哮喘和炎性肠病（IBD）。

6.

发明授权
.beta.-oxo-.beta.-benzenepropanethioamide compounds 失效
标题翻译： β-氧代-β-苯丙烷硫代酰胺化合物

公开(公告)号：US5332833A

公开(公告)日：1994-07-26

申请号：US996404

申请日：1992-12-23

申请人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino

发明人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino

IPC分类号： A61K31/16 , A61K31/18 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/496 , A61K31/50 , A61K31/505 , A61P1/00 , A61P9/08 , A61P9/12 , A61P11/00 , A61P11/08 , A61P29/00 , C07C327/42 , C07C327/44 , C07C327/46 , C07D207/327 , C07D213/59 , C07D231/12 , C07D233/54 , C07D233/58 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/84 , C07D233/90 , C07D237/08 , C07D263/32 , C07D277/20 , C07D277/30 , C07C327/38 , A61K31/165 , C07C327/48 , C07D233/96

CPC分类号： C07C327/46 , C07C327/44 , C07C2101/02 , C07C2101/04 , C07C2101/08

摘要： The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.

摘要翻译： 本发明的β-氧代-β-苯丙烷硫代酰胺衍生物具有钾通道开放作用，可用于治疗高血压，哮喘，过敏性结肠综合征和肠炎，包括血管扩张，支气管扩张，胃肠道松弛等药理作用平滑肌等。本发明还包括含有本发明化合物作为有效成分的药物组合物及其制造方法。

7.

发明申请
PROCESSES FOR CONVERTING CARBOXAMIDES TO THIOCARBOXAMIDES 有权

公开(公告)号：US20180118675A1

公开(公告)日：2018-05-03

申请号：US15572451

申请日：2016-05-06

申请人： Vertellus Holdings LLC

发明人： Martin P. GRENDZE , Ramiah MURUGAN

IPC分类号： C07C327/46 , C07C327/44 , C07C327/42 , C07B45/00 , C07D211/60

CPC分类号： C07C327/46 , C07B45/00 , C07C327/42 , C07C327/44 , C07D211/60 , C07F9/165

摘要： Process for converting a carboxamide to a thiocarboxamide includes reacting (a) a substrate that comprises a heteroatom-containing moiety and a carboxamide moiety with (b) a dialkyl dithiophosphate and/or a salt thereof. The heteroatom-containing moiety includes a heteroatom selected from the group consisting of N, O, and S. Processes for preparing piperidine-4-thiocarboxamide are described.