公开(公告)号：US20070187003A1

公开(公告)日：2007-08-16

申请号：US10591475

申请日：2005-03-01

申请人： Mitsuo Takashima ,  Kentaro Takada ,  Zenji Iida ,  Katsuhiro Tsukiyama ,  Takehiko Egawa ,  Yuichi Namimura ,  Nobuhiko Ibaraki

发明人： Mitsuo Takashima ,  Kentaro Takada ,  Zenji Iida ,  Katsuhiro Tsukiyama ,  Takehiko Egawa ,  Yuichi Namimura ,  Nobuhiko Ibaraki

IPC分类号： C22C38/00

CPC分类号： C22C38/02 ,  C22C38/04 ,  C22C38/18 ,  F16B35/00

摘要： Disclosed is a high-strength bolt having a tensile strength of 1,200 N/mm2 or more and superior in delayed fracture resistance and relaxation resistance, prepared by wire-drawing a bolt steel containing the following elements: C: 0.5 to 1.0% (mass %, the same shall apply hereinafter), Si: 0.55 to 3%, Mn: 0.2 to 2%, P: 0.03% or less (but not 0%), S: 0.03% or less (but not 0%), and Al: 0.3% or less (but not 0%), and containing proeutectoid ferrite, proeutectoid cementite, bainite and martensite at a total areal rate of less than 20% and pearlite in balance; cold-heading the wire into a bolt shape; and then bluing the bolt in a temperature range of 100 to 500° C.

摘要翻译： 公开了通过拉拔含有以下元素的螺栓钢制备的拉伸强度为1200N / mm 2以上的耐久性和耐松弛性优异的高强度螺栓：C ：0.5〜1.0％（质量％，以下相同），Si：0.55〜3％，Mn：0.2〜2％，P：0.03％以下（但不为0％），S：0.03％以下 但不是0％），Al：0.3％以下（但不是0％），并且总共面积率小于20％的前共析铁素体，共析铁素体，贝氏体和马氏体，平衡的珠光体; 将钢丝冷拔成螺栓形状; 然后在100〜500℃的温度范围内使螺栓上蓝。

公开(公告)号：US20090311122A1

公开(公告)日：2009-12-17

申请号：US12307662

申请日：2007-07-04

申请人： Masaaki Sato ,  Minoru Takada ,  Kentaro Takada ,  Zenji Iida ,  Ryosuke Kogure

发明人： Masaaki Sato ,  Minoru Takada ,  Kentaro Takada ,  Zenji Iida ,  Ryosuke Kogure

IPC分类号： B22F3/12 ,  C22C38/16 ,  B22F3/24

CPC分类号： F16C7/02 ,  B21J5/002 ,  B21K1/766 ,  B22F3/17 ,  B22F2998/10 ,  C22C33/0264 ,  C22C38/04 ,  C22C38/16 ,  F16C7/023 ,  F16C9/045 ,  Y10T74/2142 ,  B22F3/10

摘要： A member produced by powder forging which retains machinability and improved fatigue strength without having an increased hardness and can retain self conformability after fracture splitting; a powder mixture for powder forging; a process for producing a member by powder forging; and a fracture splitting connecting rod obtained from the member produced by powder forging. The member produced by powder forging is one obtained by preforming a powder mixture, subsequently sintering the preform, and forging the resultant sintered preform at a high temperature. The free-copper proportion in the sintered preform at the time when the forging is started is 10% or lower, and the member obtained through the forging has a composition containing, in terms of mass %, 0.2-0.4% C, 3-5% Cu, and up to 0.4% Mn (excluding 0), the remainder being iron and incidental impurities, and has a ferrite content of 40-90%.

摘要翻译： 通过粉末锻造制成的构件，其保持机械加工性和改善的疲劳强度，而不增加硬度并且可以在断裂后保持自适应性; 用于粉末锻造的粉末混合物; 通过粉末锻造制造构件的方法; 以及由由粉末锻造制成的构件获得的断裂连接杆。 通过粉末锻造制造的构件是通过预先形成粉末混合物，随后烧结预成型件和在高温下锻造所得到的烧结预成型体而获得的构件。 锻造开始时的烧结预成型体中的游离铜比例为10％以下，通过锻造得到的成分的组成为以质量％计含有0.2〜0.4％的C，3-5 ％Cu和高达0.4％的Mn（不包括0），其余为铁和杂质，铁素体含量为40-90％。

公开(公告)号：US20060000088A1

公开(公告)日：2006-01-05

申请号：US11221853

申请日：2005-09-09

申请人： Tatsuya Hasegawa ,  Zenji Iida ,  Kentaro Takada

发明人： Tatsuya Hasegawa ,  Zenji Iida ,  Kentaro Takada

IPC分类号： B21D53/84

CPC分类号： F16C7/023 ,  F16C9/045 ,  Y10T29/49288 ,  Y10T29/49291 ,  Y10T74/2142

摘要： A non-heat treated connecting rod which comprises, by mass %, C: 0.25-0.35%, Si: 0.50-0.70%, Mn: 0.60-0.90%, P: 0.040-0.070%, S: 0.040-0.130%, Cr: 0.10-0.20%, V: 0.15-0.20%, Ti: 0.15-0.20% and N: 0.002-0.020%, and the balance Fe and impurities, with chemical compositions being less than 0.80 in the value of C+(Si/10)+(Mn/5)+(5Cr/22)+1.65 V−(5S/7) using the symbol of the element as its content, the microstructure of the Big end of the said connecting rod being ferrite-pearlite, all-region hardness of the said big end being 255 to 320 in Vickers hardness, the ferrite-region hardness in the said ferrite-pearlite of the Big end being 250 or more in Vickers hardness and the ratio of the said ferrite-region hardness to the said all-region hardness of the said Big end being 0.80 or more, is excellent in machinability, fracture splitting ability, and fatigue resistance, although no Pb at all is added. Therefore, this non-heat treated connecting rod can be utilized as a low cost type connecting rod in automobile engines or the like.

摘要翻译： 1.一种非热处理连杆，其以质量％计含有C：0.25-0.35％，Si：0.50-0.70％，Mn：0.60-0.90％，P：0.040-0.070％，S：0.040-0.130％，Cr ：0.10-0.20％，V：0.15-0.20％，Ti：0.15-0.20％和N：0.002-0.020％，余量为Fe和杂质，化学成分小于0.80（C +（Si / 10） ）+（Mn / 5）+（5Cr / 22）+1.65V-（5S / 7），使用元素的符号作为其含量，所述连杆的大端的微结构为铁素体 - 珠光体， 所述大端的区域硬度维氏硬度为255〜320，所述大端的所述铁素体 - 珠光体的铁素体区硬度为维氏硬度为250以上，所述铁素体区硬度与所述 所述大端的全区域硬度为0.80以上，尽管不添加Pb，但是其切削性，断裂能力和耐疲劳性优异。 因此，这种未经热处理的连杆可用作汽车发动机等中的低成本型连杆。

公开(公告)号：US08152939B2

公开(公告)日：2012-04-10

申请号：US11221853

申请日：2005-09-09

申请人： Tatsuya Hasegawa ,  Zenji Iida ,  Kentaro Takada

发明人： Tatsuya Hasegawa ,  Zenji Iida ,  Kentaro Takada

IPC分类号： C22C38/00 ,  C21D8/00

CPC分类号： F16C7/023 ,  F16C9/045 ,  Y10T29/49288 ,  Y10T29/49291 ,  Y10T74/2142

摘要： A non-heat treated connecting rod which comprises, by mass %, C: 0.25-0.35%, Si: 0.50-0.70%, Mn: 0.60-0.90%, P: 0.040-0.070%, S: 0.040-0.130%, Cr: 0.10-0.20%, V: 0.15-0.20%, Ti: 0.15-0.20% and N: 0.002-0.020%, and the balance Fe and impurities, with chemical compositions being less than 0.80 in the value of C+(Si/10)+(Mn/5)+(5Cr/22)+1.65 V−(5S/7) using the symbol of the element as its content, the microstructure of the Big end of the said connecting rod being ferrite-pearlite, all-region hardness of the said big end being 255 to 320 in Vickers hardness, the ferrite-region hardness in the said ferrite-pearlite of the Big end being 250 or more in Vickers hardness and the ratio of the said ferrite-region hardness to the said all-region hardness of the said Big end being 0.80 or more, is excellent in machinability, fracture splitting ability, and fatigue resistance, although no Pb at all is added. Therefore, this non-heat treated connecting rod can be utilized as a low cost type connecting rod in automobile engines or the like.

摘要翻译： 1.一种非热处理连杆，其以质量％计含有C：0.25-0.35％，Si：0.50-0.70％，Mn：0.60-0.90％，P：0.040-0.070％，S：0.040-0.130％，Cr ：0.10-0.20％，V：0.15-0.20％，Ti：0.15-0.20％和N：0.002-0.020％，余量为Fe和杂质，化学成分小于0.80（C +（Si / 10） ）+（Mn / 5）+（5Cr / 22）+1.65V-（5S / 7），使用元素的符号作为其含量，所述连杆的大端的微结构为铁素体 - 珠光体， 所述大端的区域硬度维氏硬度为255〜320，所述大端的所述铁素体 - 珠光体的铁素体区硬度为维氏硬度为250以上，所述铁素体区硬度与所述 所述大端的全区域硬度为0.80以上，尽管不添加Pb，但是其切削性，断裂能力和耐疲劳性优异。 因此，这种未经热处理的连杆可用作汽车发动机等中的低成本型连杆。

公开(公告)号：US20100317732A1

公开(公告)日：2010-12-16

申请号：US12811144

申请日：2008-12-29

申请人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

发明人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

IPC分类号： A61K31/35 ,  A61K31/165 ,  C07C211/00 ,  A61P35/02 ,  A61P35/04

CPC分类号： A61K31/277 ,  A61K31/165 ,  A61K31/353 ,  C07C235/34 ,  C07C255/54 ,  C07C291/10 ,  C07D311/92

摘要： Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

摘要翻译： 公开了增强肿瘤细胞化学治疗，降低癌细胞对化学治疗剂的抗性的方法，抑制患有癌症的哺乳动物中的ABCG2，Pgp或MRP1的方法，以及增加ABCG2的生物利用度的方法 哺乳动物中的底物药物。 所述方法包括向哺乳动物施用有效量的某些化合物，例如式（I）的化合物：式（I），其中R 1，R 2，R 3，X 1，X 2，X 3，a和b如上所述 这里。 还公开了这些化合物在制备药物中的用途。 还公开了式（II）的化合物，包含这些化合物的药物组合物及其用途。

公开(公告)号：US20140053955A1

公开(公告)日：2014-02-27

申请号：US14003508

申请日：2012-04-17

申请人： Kentaro Takada ,  Hiroki Terada ,  Shinichiro Kato

发明人： Kentaro Takada ,  Hiroki Terada ,  Shinichiro Kato

IPC分类号： C22C38/32 ,  C22C38/02 ,  C22C38/22 ,  C22C38/04 ,  C22C38/28 ,  C22C38/24

CPC分类号： C22C38/32 ,  C21D1/25 ,  C21D9/0068 ,  C21D9/46 ,  C21D2211/004 ,  C21D2211/005 ,  C21D2211/009 ,  C22C38/02 ,  C22C38/04 ,  C22C38/22 ,  C22C38/24 ,  C22C38/28 ,  F16G5/16

摘要： A steel used in a belt-type CVT that is superior in wear resistance and toughness, and a steel for cold punching, that provides the same. The steel satisfies the following: 10.8 [C]+5.6 [Si]+2.7 [Mn]+0.3 [Cr]+7.8 [Mo]+1.4 [V]≦13. The steel contains C within the range of 0.50 to 0.70%, Si within the range of 0.03 to 0.60%, Mn within the range of 0.50 to 1.00%, Cr within the range of 0.20 to 1.00%, Ti within the range of 0.01 to 0.10%, and B within the range of 0.0005 to 0.0050% by mass as required additional elements, P within the range of 0.025% or less and S within the range of 0.015% or less by mass as optional additional elements, and the remainder as Fe and unavoidable impurities.

摘要翻译： 用于耐磨性和韧性优异的带式CVT的钢和用于冷冲压的钢，提供相同的。 钢满足以下条件：10.8 [C] +5.6 [Si] +2.7 [Mn] +0.3 [Cr] +7.8 [Mo] +1.4 [V] @ 13。 钢含有0.50〜0.70％的C，0.03〜0.60％的Si，0.50〜1.00％的Mn，0.20〜1.00％的Cr，0.01〜 0.10％，B为0.0005〜0.0050质量％，P为0.025％以下，S为0.015质量％以下，S为0.015质量％以下，余量为 Fe和不可避免的杂质。

公开(公告)号：US08470888B2

公开(公告)日：2013-06-25

申请号：US12811144

申请日：2008-12-29

申请人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

发明人： Curtis J. Henrich ,  Heidi R. Bokesch ,  Laura K. Cartner ,  Richard W. Fuller ,  Kirk R. Gustafson ,  Kentaro Takada ,  James B. McMahon ,  Susan E. Bates ,  Robert W. Robey ,  Suneet Shukla ,  Suresh V. Ambudkar ,  Michael C. Dean

IPC分类号： A61K31/12 ,  C07C59/86

CPC分类号： A61K31/277 ,  A61K31/165 ,  A61K31/353 ,  C07C235/34 ,  C07C255/54 ,  C07C291/10 ,  C07D311/92

摘要： Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

摘要翻译： 公开了增强肿瘤细胞化学治疗，降低癌细胞对化学治疗剂的抗性的方法，抑制患有癌症的哺乳动物中的ABCG2，Pgp或MRP1的方法，以及增加ABCG2的生物利用度的方法 哺乳动物中的底物药物。 所述方法包括向哺乳动物施用有效量的某些化合物，例如式（I）的化合物：式（I），其中R 1，R 2，R 3，X 1，X 2，X 3，a和b如上所述 这里。 还公开了这些化合物在制备药物中的用途。 还公开了式（II）的化合物，包含这些化合物的药物组合物及其用途。