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    COMPOSITIONS AND METHODS FOR THE PRODUCTION AND DELIVERY OF DOUBLE STRANDED RNA
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR THE PRODUCTION AND DELIVERY OF DOUBLE STRANDED RNA 有权
    用于生产和递送双链RNA的组合物和方法

    公开(公告)号：US20140271559A1

    公开(公告)日：2014-09-18

    申请号：US14208788

    申请日：2014-03-13

    Applicant: Monsanto Technology LLC

    Inventor： James A. Baum ,  Allen T. Christian ,  Artem Evdokimov ,  Farhad Moshiri ,  Lisa Marie Weaver ,  Haitao Zhang

    IPC: A01N63/02

    CPC classification number: A01N63/02 ,  A01H3/00 ,  A01N63/00 ,  C12N9/22 ,  C12N15/67 ,  C12N15/72

    Abstract: Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.

    Abstract translation: 提供了有效生产和递送双链RNA（dsRNA）的组合物和方法。 描述了可用于dsRNA的体外和体内表达的载体构建体。 还描述了用于在活细胞中有效和成本有效地生产dsRNA的细胞表达系统，以及用于将表达的dsRNA提供给靶生物的方法和组合物。 所述的组合物和方法可用于产生用于筛选或其它用途的RNA分子，并扩增用于分析的RNA序列。

    Bacillus thuringiensis toxin receptors and uses thereof
    9.
    发明授权
    Bacillus thuringiensis toxin receptors and uses thereof 有权

    公开(公告)号：US11274138B2

    公开(公告)日：2022-03-15

    申请号：US15940962

    申请日：2018-03-29

    Applicant: MONSANTO TECHNOLOGY LLC

    Inventor： Edward Kraft ,  Renata Bolognesi ,  Artem Evdokimov ,  Farhad Moshiri ,  Meiying Zheng ,  Victor M. Guzov

    IPC: C07K14/705 ,  G01N33/50 ,  C12N9/16 ,  C07K14/435 ,  C12N9/48 ,  C12N9/64 ,  C12N15/63 ,  C12N5/10

    Abstract: The invention relates to identification and characterization of recombinant DNA and polypeptides for specific Bt toxin receptors. In particular, the Bt toxin receptors of the invention include those derived from the Lepidopteran super family including the species Trichoplusiani ni, Pseudoplusia includens, Helicoverpa zea, and Spodoptera frugiperda. The receptors of the invention further include those derived from the Coleopteran super family and particularly from the species Diabrotica virgifera virgifera. The recombinant DNA and polypeptides so provided are useful in the identification and design of novel Bt toxin receptor ligands including novel or improved insecticidal toxins for use in a variety of agricultural applications. Materials and methods for identifying novel toxins are also disclosed herein. The invention also provides methods for selecting toxins to combine to control insect populations by manipulating Bt toxin receptor.

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