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公开(公告)号：US20240262872A1
公开(公告)日：2024-08-08
申请号：US18595330
申请日：2024-03-04
发明人： James A. Baum , Artem G. Evdokimov , Stanislaw Flasinski , Farhad Moshiri , Timothy J. Rydel , Eric J. Sturman , Moritz von Rechenberg , Halong Vu , Andrew M. Wollacott , Meiying Zheng
IPC分类号： C07K14/325 , A01N37/46 , C07K14/00 , C07K14/32 , C07K14/435 , C12N15/82
CPC分类号： C07K14/325 , A01N37/46 , C07K14/001 , C07K14/32 , C07K14/43577 , C12N15/8286 , Y02A40/146
摘要： The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.
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公开(公告)号：US11939589B2
公开(公告)日：2024-03-26
申请号：US17729892
申请日：2022-04-26
发明人： James A. Baum , Claire A. CaJacob , Pascale Feldmann , Gregory R. Heck , Irene Maria Antonia Nooren , Geert Plaetinck , Wendy T. Maddelein , Ty T. Vaughn
IPC分类号： C12N15/82 , C07H21/04 , C07K14/435 , C12N15/113
CPC分类号： C12N15/8286 , C07H21/04 , C07K14/43536 , C07K14/43563 , C12N15/113 , C12N15/8218 , C12N15/8282 , C12N15/8285 , Y02A40/146
摘要： The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US11702455B2
公开(公告)日：2023-07-18
申请号：US16894459
申请日：2020-06-05
发明人： James A. Baum , David J. Bowen , Catherine A. Chay , David J. Chi , William P. Clinton , Crystal L. Dart , Leigh English , Stanislaw Flasinski , Victor M. Guzov , Kevin A. Jarrell , Uma R. Kesanapalli , Thomas M. Malvar , Robert M. McCarroll , Jason S. Milligan , Jay P. Morgenstern , Deborah G. Rucker , Sara A. Salvador , Temple F. Smith , Carlos E. Soto , Collin M. Stultz , Brian M. Turczyk , Ty T. Vaughn , Moritz W. F. Von Rechenberg
IPC分类号： C07K14/325 , C12N15/82 , A01N63/50
CPC分类号： C07K14/325 , A01N63/50 , C12N15/8286 , Y02A40/146 , A01N63/50 , A01N63/23 , A01N63/50 , A01N63/50
摘要： Disclosed herein are nucleotide sequences encoding an insecticidal protein exhibiting Lepidopteran inhibitory activity, as well as novel insecticidal proteins referred to herein as a BCW 001, BCW 002, BCW 003, and BCW toxic protein-containing chimeras and BCW toxin insecticide, transgenic plants expressing the chimeras or the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.
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公开(公告)号：US20230018327A1
公开(公告)日：2023-01-19
申请号：US17815122
申请日：2022-07-26
发明人： James A. Baum , Thomas Cerruti , Stainslaw Flasinski , Xiaoran Fu , Arlene R. Howe , Sara Ann Salvador
IPC分类号： C12N15/82 , A01N47/08 , A01N63/50 , C07K14/325
摘要： Engineered Cry1Da amino acid sequences are provided that exhibit improved Lepidopteran insecticidal activity and an enhanced Lepidopteran spectrum compared to the naturally occurring Cry1Da protein toxin. Polynucleotide sequences intended for use in expression of the improved proteins in plants are also provided. Particular embodiments provide compositions containing insect inhibitory amounts of the engineered proteins, as well as recombinant plants, plant parts, and seeds containing polynucleotide constructs encoding one or more of the improved engineered proteins.
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公开(公告)号：US20220356214A1
公开(公告)日：2022-11-10
申请号：US17742215
申请日：2022-05-11
发明人： James A. Baum , Artem G. Evdokimov , Farhad Moshiri , Timothy J. Rydel , Eric J. Sturman , Moritz von Rechenberg , Halong Vu , Andrew M. Wollacott , Meiying Zheng
IPC分类号： C07K14/325 , C12N15/82 , C07K14/00 , A01N37/46 , C07K14/435 , C07K14/32
摘要： The present invent in discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.
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公开(公告)号：US20220267793A1
公开(公告)日：2022-08-25
申请号：US17689613
申请日：2022-03-08
发明人： James A. Baum , Larry A. Gilbertson , David K. Kovalic , Thomas J. Larosa , Maolong Lu , Tichafa R. I. Munyikwa , James K. Roberts , Wei Wu , Bei Zhang
摘要： The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US11286284B2
公开(公告)日：2022-03-29
申请号：US16658938
申请日：2019-10-21
发明人： James A. Baum , Thomas A. Cerruti , Crystal L. Dart , Leigh H. English , Stanislaw Flasinski , Xiaoran Fu , Victor M. Guzov , Arlene R. Howe , Jay P. Morgenstern , James K. Roberts , Sara Salvador , Jinling Hung Wang
IPC分类号： C07K14/325 , C12N15/82 , A01N37/46 , C12N15/62
摘要： Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
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公开(公告)号：US10897910B2
公开(公告)日：2021-01-26
申请号：US16594713
申请日：2019-10-07
发明人： James A. Baum , Artem G. Evdokimov , Farhad Moshiri , Timothy J. Rydel , Eric J. Sturman , Moritz von Rechenberg , Halong Vu , Andrew M. Wollacott , Meiying Zheng
IPC分类号： C12N1/20 , A01N63/10 , C12N15/82 , C07K14/00 , A01N37/46 , C07K14/435 , C07K14/325 , C07K14/32
摘要： The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.
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公开(公告)号：US10757947B2
公开(公告)日：2020-09-01
申请号：US16103451
申请日：2018-08-14
发明人： James A. Baum , Allen T. Christian , Artem Evdokimov , Farhad Moshiri , Lisa Marie Weaver , Haitao Zhang
摘要： Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.
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10.发明申请公开(公告)号：US20200172922A1
公开(公告)日：2020-06-04
申请号：US16706285
申请日：2019-12-06
发明人： James A. Baum , Claire A. CaJacob , Pascale Feldman , Gregory R. Heck , Irene Maria Antonia Nooren , Geert Plaetinck , Wendy T. Maddelein , Ty T. Vaughn
IPC分类号： C12N15/82 , C07H21/04 , C07K14/435 , C12N15/113
摘要： The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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