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公开(公告)号：US06534084B1
公开(公告)日：2003-03-18
申请号：US09740289
申请日：2000-12-19
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A61F1300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US06365149B2
公开(公告)日：2002-04-02
申请号：US09740086
申请日：2000-12-19
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A01N6300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US06355699B1
公开(公告)日：2002-03-12
申请号：US09345095
申请日：1999-06-30
IPC分类号： C08J926
CPC分类号： C08J9/26 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , C08J9/28 , C08J2367/02 , C08L67/04
摘要： The present invention provides an improved lyophilization process for forming biocompatible foam structures. The process allows the foam structures to be tailored for specific end uses. The foams formed by this process are well suited to be used in medical applications such as tissue engineering. The foam structures may also contain pharmaceutically active substances
摘要翻译： 本发明提供了用于形成生物相容性泡沫结构的改进的冻干方法。 该方法允许为特定的最终用途定制泡沫结构。 由该方法形成的泡沫非常适用于医疗应用如组织工程。 泡沫结构还可以含有药物活性物质
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公开(公告)号：US06306424B1
公开(公告)日：2001-10-23
申请号：US09469118
申请日：1999-12-21
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
IPC分类号： A61F200
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了一种生物相容性复合材料，其由连接到通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫的第一纤维层制成。 这些复合材料可以由可吸收和生物相容性聚合物的混合物制成。 这些生物相容性复合材料特别适用于组织工程应用，可以设计为模拟组织转变或界面区域。
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公开(公告)号：US07112417B2
公开(公告)日：2006-09-26
申请号：US09938364
申请日：2001-08-24
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
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公开(公告)号：US06333029B1
公开(公告)日：2001-12-25
申请号：US09345096
申请日：1999-06-30
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A01N6300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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