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公开(公告)号：US06534084B1
公开(公告)日：2003-03-18
申请号：US09740289
申请日：2000-12-19
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A61F1300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US06365149B2
公开(公告)日：2002-04-02
申请号：US09740086
申请日：2000-12-19
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A01N6300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US06306424B1
公开(公告)日：2001-10-23
申请号：US09469118
申请日：1999-12-21
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
IPC分类号： A61F200
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了一种生物相容性复合材料，其由连接到通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫的第一纤维层制成。 这些复合材料可以由可吸收和生物相容性聚合物的混合物制成。 这些生物相容性复合材料特别适用于组织工程应用，可以设计为模拟组织转变或界面区域。
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公开(公告)号：US07112417B2
公开(公告)日：2006-09-26
申请号：US09938364
申请日：2001-08-24
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
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公开(公告)号：US06333029B1
公开(公告)日：2001-12-25
申请号：US09345096
申请日：1999-06-30
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A01N6300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US06355699B1
公开(公告)日：2002-03-12
申请号：US09345095
申请日：1999-06-30
IPC分类号： C08J926
CPC分类号： C08J9/26 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , C08J9/28 , C08J2367/02 , C08L67/04
摘要： The present invention provides an improved lyophilization process for forming biocompatible foam structures. The process allows the foam structures to be tailored for specific end uses. The foams formed by this process are well suited to be used in medical applications such as tissue engineering. The foam structures may also contain pharmaceutically active substances
摘要翻译： 本发明提供了用于形成生物相容性泡沫结构的改进的冻干方法。 该方法允许为特定的最终用途定制泡沫结构。 由该方法形成的泡沫非常适用于医疗应用如组织工程。 泡沫结构还可以含有药物活性物质
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公开(公告)号：US07012106B2
公开(公告)日：2006-03-14
申请号：US10401469
申请日：2003-03-28
申请人： Jenny J. Yuan , Joseph H. Contiliano , Yufu Li , Zhigang Li , Mark B. Roller , Murty N. Vyakarnam
发明人： Jenny J. Yuan , Joseph H. Contiliano , Yufu Li , Zhigang Li , Mark B. Roller , Murty N. Vyakarnam
CPC分类号： A61L31/127 , A61L31/125 , A61L31/148 , Y10S525/937
摘要： The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.
摘要翻译： 本发明涉及适用于至少部分由这样的组合物制备的可植入医疗装置和医疗装置的增强的，生物相容的，可生物降解的组合物，其中组合物包括生物相容的可生物降解的聚合物; 生物相容的，可生物降解的蜡; 和大于约30重量％的无机填料。
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公开(公告)号：US06325810B1
公开(公告)日：2001-12-04
申请号：US09345093
申请日：1999-06-30
申请人： Leslie Hamilton , Rao S. Bezwada , Mark B. Roller , Murty N. Vyakarnam , David A. Dalessandro , Joel S. Rosenblatt , Ram L. Kataria , Lowell G. Saferstein , James F. Martin
发明人： Leslie Hamilton , Rao S. Bezwada , Mark B. Roller , Murty N. Vyakarnam , David A. Dalessandro , Joel S. Rosenblatt , Ram L. Kataria , Lowell G. Saferstein , James F. Martin
IPC分类号： A61B1704
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00004 , A61B2017/07214
摘要： An apparatus for achieving hemostasis and pneumostasis along a staple line by utilizing a compliant bioabsorbable foam buttress which may be attached to one jaw of a surgical stapling apparatus by a biocompatible releasable adhesive.
摘要翻译： 一种用于通过使用柔性生物可吸收的泡沫支撑件，通过生物相容的可释放粘合剂附着到外科缝合装置的一个钳口上，沿着缝合线实现止血和肺静止的装置。
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9.发明申请Medical Devices, Drug Coatings And Methods For Maintaining The Drug Coatings Thereon 审中-公开医疗器械，药物涂层和维护药物涂层的方法公开(公告)号：US20100285089A1
公开(公告)日：2010-11-11
申请号：US12839918
申请日：2010-07-20
IPC分类号： A61F2/82 , A61K31/436 , A61P9/00
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In particular, disclosed herein is a drug delivery device comprising a balloon-expandable intraluminal stent, and a pharmaceutical agent-containing coating, wherein the coating comprises a biocompatible polyfluoro copolymer that comprises about eighty-five weight percent vinylidinefluoride copolymerized with about fifteen weight percent hexafluoropropylene and a pharmaceutical agent intermixed with said polyfluoro copolymer.
摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 特别地，本文公开了一种药物递送装置，其包括球囊可扩张的管腔内支架和含药剂的涂层，其中所述涂层包含生物相容性多氟共聚物，其包含与约十五重量％六氟丙烯共聚的约八十五重量％的偏二氟乙烯 和与所述多氟共聚物混合的药剂。
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公开(公告)号：US07591844B2
公开(公告)日：2009-09-22
申请号：US11941351
申请日：2007-11-16
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61L31/16 , A61L2300/00 , A61L2300/41 , A61L2300/416 , A61L2300/606 , B05D3/0254 , Y10T428/3154 , C08L27/12 , C08L27/16 , C08L27/14
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
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