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公开(公告)号：US20220079994A1
公开(公告)日：2022-03-17
申请号：US17536841
申请日：2021-11-29
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
摘要： Methods are provided for treatment of several conditions of one or more body features, where the method comprises implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose matrix. The delipidated, decellularized adipose tissue matrix is produced by delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting matrix contains a proportion of lipids which is less than the proportion of lipids contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating. The delipidated, decellularized adipose matrix may be provided as particles, a slurry, a paste, a gel, an injectable form, or in some other form.
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公开(公告)号：US10596201B2
公开(公告)日：2020-03-24
申请号：US16121969
申请日：2018-09-05
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
摘要： An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
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3.发明申请公开(公告)号：US20150037436A1
公开(公告)日：2015-02-05
申请号：US14446629
申请日：2014-07-30
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
IPC分类号： A61K35/12
CPC分类号： A61K35/35 , A61L27/3604 , A61L27/3683 , A61L2430/40
摘要： An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
摘要翻译： 无细胞软组织衍生基质包括已被脱脂和脱细胞的胶原组织。 脂肪组织是适合制造无细胞软组织衍生基质的软组织之一。 外源性组织细胞和其他生物活性因子可以加入到无细胞基质中。 无细胞基质可以作为颗粒，浆液，糊剂，凝胶或其它形式提供。 无细胞基质可以提供为已经从三维组织的颗粒重构的三维支架。 三维支架可以具有解剖特征的形状并且用作用于组织修复或替换的模板。 制备无细胞软组织衍生基质的方法包括通过溶液萃取和软组织的化学脱细胞化从软组织中除去脂质的步骤。
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公开(公告)号：US11779610B2
公开(公告)日：2023-10-10
申请号：US17536841
申请日：2021-11-29
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
CPC分类号： A61K35/35 , A61L27/3604 , A61L27/3683 , A61L2430/40
摘要： Methods are provided for treatment of several conditions of one or more body features, where the method comprises implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose matrix. The delipidated, decellularized adipose tissue matrix is produced by delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting matrix contains a proportion of lipids which is less than the proportion of lipids contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating. The delipidated, decellularized adipose matrix may be provided as particles, a slurry, a paste, a gel, an injectable form, or in some other form.
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公开(公告)号：US20170119826A1
公开(公告)日：2017-05-04
申请号：US15388428
申请日：2016-12-22
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
CPC分类号： A61K35/35 , A61L27/3604 , A61L27/3683 , A61L2430/40
摘要： An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
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公开(公告)号：US20230270794A1
公开(公告)日：2023-08-31
申请号：US18143316
申请日：2023-05-04
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
CPC分类号： A61K35/35 , A61L27/3604 , A61L27/3683 , A61L2430/40
摘要： Methods are provided for treatment of several conditions of one or more body features, where the method comprises implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose matrix. The delipidated, decellularized adipose tissue matrix is produced by delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting matrix contains a proportion of lipids which is less than the proportion of lipids contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating. The delipidated, decellularized adipose matrix may be provided as particles, a slurry, a paste, a gel, an injectable form, or in some other form.
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公开(公告)号：US20190008903A1
公开(公告)日：2019-01-10
申请号：US16121969
申请日：2018-09-05
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
摘要： An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
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公开(公告)号：US10092600B2
公开(公告)日：2018-10-09
申请号：US15388428
申请日：2016-12-22
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo
摘要： An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
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9.发明申请公开(公告)号：US20170021058A1
公开(公告)日：2017-01-26
申请号：US15217409
申请日：2016-07-22
发明人： Yen-Chen Huang , Asia Ivery , Bryan Choi , Benjamin Schilling , Manh-Dan Ngo , Evangelia Chnari , Todd Nilsen
IPC分类号： A61L27/36 , A61L27/54 , A61L27/38 , C12N5/077 , C12N5/0775
CPC分类号： A61L27/3604 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2300/64 , A61L2400/06 , A61L2430/34 , C12N5/0653 , C12N5/0667 , C12N2533/92
摘要： A composition including delipidated, decellularized adipose tissue and delipidated, decellularized fascial tissue is provided. The composition may further include exogenous tissuegenic cells, an exogenous growth-inductive substance, and/or a carrier. The composition is suitable for implantation into a living body in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, wound care procedures or other procedures of regenerative medicine. A method of preparing an acellular soft tissue-derived matrix from adipose tissue and fascial tissue is also provided. The method involves preparing a delipidated, decellularized adipose-derived matrix by delipidizing the adipose tissue and decellularizing the adipose tissue; preparing a delipidated, decellularized fascia-derived matrix by delipidizing the fascial tissue and decellularizing the fascial tissue; and combining the delipidated, decellularized adipose-derived matrix and the delipidated, decellularized fascia-derived matrix to produce said acellular soft tissue-derived matrix. The resulting Acellular soft tissue-derived matrix may be partially dried, substantially dried, or not dried.
摘要翻译： 提供了包含脱脂，脱细胞脂肪组织和脱脂，脱细胞的筋膜组织的组合物。 该组合物可进一步包括外源性组织生成细胞，外源生长诱导物质和/或载体。 该组合物适于在整形手术中植入生物体，包括重建或整容手术程序，伤口护理程序或再生医学的其他程序。 还提供了从脂肪组织和筋膜组织制备无细胞软组织衍生基质的方法。 该方法包括通过使脂肪组织脱脂并使脂肪组织脱细胞来制备脱脂，脱细胞脂肪来源的基质; 通过使筋膜组织脱水和脱细胞化筋膜组织来制备脱脂，去细胞化的筋膜衍生基质; 并且将脱脂，脱细胞脂肪来源的基质和脱脂的去细胞化的筋膜衍生的基质组合以产生所述无细胞软组织衍生的基质。 得到的无细胞软组织衍生基质可以被部分干燥，基本干燥或不干燥。
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