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    Genes encoding several poly (ADP-RIBOSE) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
    1.
    发明申请
    Genes encoding several poly (ADP-RIBOSE) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith 有权
    编码几种聚（ADP-RIBOSE）糖水解酶（PARG）酶的基因，其蛋白质及其片段和与其免疫反应的抗体

    公开(公告)号：US20070136833A1

    公开(公告)日：2007-06-14

    申请号：US11638012

    申请日：2006-12-13

    申请人： Myron Jacobson ,  Elaine Jacobson ,  Jean-Christophe Ame ,  Winston Lin

    发明人： Myron Jacobson ,  Elaine Jacobson ,  Jean-Christophe Ame ,  Winston Lin

    IPC分类号： A01K67/027 ,  C12Q1/68 ,  C07H21/02 ,  A61K48/00 ,  C12P21/06 ,  A61K39/395 ,  C12N9/22 ,  C07H21/04

    CPC分类号： C12Y302/01143 ,  A01K2217/075 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/2402 ,  C12Q1/34

    摘要： The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods for inhibiting PARG expression or overexpressing PARG in a subject for therapeutic benefit are described. Exemplary of PARG inhibitors are anti-sense oligonucleotides. The invention has implications for treatment of neoplastic disorder, heart attack, stroke, and neurodegenerative diseases. Methods for detecting a mutant PARG allele are also described. Antibodies immunoreactive with PARGs and fragments thereof are described.

    摘要翻译： 描述了编码聚（ADP-核糖）糖水解酶（PARG）酶的cDNA和来自几种物种的PARG的氨基酸序列的分离和表征。 PARG参与对DNA损伤的细胞反应，其适当的功能与身体对肿瘤性疾病诱导剂和氧化应激的反应有关。 描述了含有cDNA和用载体转化的细胞的表达载体。 描述了与cDNA杂交的探针和引物。 cDNA在大肠杆菌中的表达产生约111kDa的酶活性蛋白质和约59kDa的活性片段。 描述了用于抑制受试者中PARG表达或过表达PARG的治疗益处的方法。 PARG抑制剂的示例是反义寡核苷酸。 本发明对于治疗肿瘤性疾病，心脏病发作，中风和神经变性疾病具有意义。 还描述了用于检测突变型PARG等位基因的方法。 描述了与PARG及其片段免疫反应的抗体。

    Method for inducing cell death with carbonyl scavengers
    3.
    发明申请
    Method for inducing cell death with carbonyl scavengers 有权
    用羰基清除剂诱导细胞死亡的方法

    公开(公告)号：US20050197400A1

    公开(公告)日：2005-09-08

    申请号：US11069292

    申请日：2005-03-01

    申请人： Georg Wondrak ,  Myron Jacobson ,  Elaine Jacobson

    发明人： Georg Wondrak ,  Myron Jacobson ,  Elaine Jacobson

    IPC分类号： A61K31/155 ,  A61K31/195 ,  A61K31/198

    CPC分类号： A61K31/155 ,  A61K31/195 ,  A61K31/198

    摘要： Carbonyl scavengers, which have been recognized for their ability to react with reactive carbonyl species, have been implicated as agents that can accelerate or induce the death of abnormal cells without having a parallel effect on normal cells. As such, they are useful therapeutic agents in cases where the acceleration or induction of cell death is desirable, such as in cells where the normal apoptotic pathways have been disrupted and where hyperproliferative cell growth occurs.

    摘要翻译： 被认为与反应性羰基物质反应的能力的羰基清除剂已经被认为是可以加速或诱导异常细胞死亡但不对正常细胞具有平行作用的试剂。 因此，在需要加速或诱导细胞死亡的情况下，例如在正常凋亡途径被破坏并且发生过度增殖细胞生长的细胞中，它们是有用的治疗剂。