公开(公告)号：US20240180860A1

公开(公告)日：2024-06-06

申请号：US18181653

申请日：2017-12-08

申请人： N.V. Nutricia

发明人： Anniek Lidewij SCHIPPER ,  Eline Marleen VAN DER BEEK ,  Dennis Stanley ACTON ,  Nana BARTKE ,  Stefanie SCHOEN

IPC分类号： A61K31/201 ,  A23L33/00 ,  A61K31/202 ,  A61K31/688 ,  A61P25/00

CPC分类号： A61K31/201 ,  A23L33/40 ,  A61K31/202 ,  A61K31/688 ,  A61P25/00

摘要： An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

公开(公告)号：US20190076490A1

公开(公告)日：2019-03-14

申请号：US15969401

申请日：2018-05-02

申请人： N.V. Nutricia

发明人： Johan GARSSEN ,  Ruurd VAN ELBURG ,  Nana BARTKE ,  Aletta Desiree KRANEVELD

IPC分类号： A61K35/745 ,  A61K31/715 ,  A23L33/21 ,  A61K31/733 ,  A61K31/198 ,  A23L33/18 ,  A61K45/06 ,  A61K9/00 ,  A61K31/202 ,  A61K31/702 ,  A23L33/175 ,  A23L33/00 ,  A23L33/12 ,  A23L33/135 ,  A61K35/00

摘要： The invention relates to nutritional compositions with Bifidobacterium breve and non-digestible oligosaccharides for use infants or toddlers for use in improving cognitive or behavioral performance or neuroinflammation.

公开(公告)号：US20160367511A1

公开(公告)日：2016-12-22

申请号：US15035057

申请日：2014-11-07

申请人： N.V. NUTRICIA

发明人： Nana BARTKE ,  Barry WOBBES

IPC分类号： A61K31/202 ,  A23L33/12 ,  A23L33/00 ,  A61K47/48

CPC分类号： A61K31/202 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/685 ,  A61K47/544 ,  A61K2300/00

摘要： The invention pertains to the use of a dietary DHA comprising phospholipid (PL-DHA) for increasing the amount of DPA or the amount of DHA and DPA in tissues and/or organs, preferably brain, eyes and liver of a young mammal, preferably a human infant. The PL-DHA is preferably comprised in infant formula.

摘要翻译： 本发明涉及包含磷脂（PL-DHA）的饮食DHA用于增加年轻哺乳动物的组织和/或器官，优选脑，眼和肝中DPA的量或DHA和DPA的量，优选地为 人类婴儿 PL-DHA优选包含在婴儿配方奶粉中。

公开(公告)号：US20170042849A1

公开(公告)日：2017-02-16

申请号：US15304279

申请日：2015-04-16

申请人： N.V. Nutricia

发明人： Ruurd VAN ELBURG ,  Nana BARTKE ,  Johan GARSSEN ,  Aletta Desiree KRANEVELD

IPC分类号： A61K31/198 ,  A61K9/00 ,  A61K31/7076 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7004 ,  A61K31/7016 ,  A23L33/175 ,  A23L33/12 ,  A23L33/17 ,  A23L33/115 ,  A23L33/135 ,  A23L33/00 ,  A23L33/125 ,  A23L33/21 ,  A61K31/202

CPC分类号： A61K31/198 ,  A23C9/206 ,  A23L2/39 ,  A23L33/115 ,  A23L33/12 ,  A23L33/125 ,  A23L33/13 ,  A23L33/135 ,  A23L33/17 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/322 ,  A23Y2300/29 ,  A61K9/0095 ,  A61K31/202 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K38/05 ,  A61K38/06 ,  A61K2300/00 ,  A23V2250/062

摘要： The invention relates to the use of glutamine, preferably in the form of free amino acids, dipeptides and/or tripeptides, in the manufacture of a nutritional composition for improving exploratory behavior, memory performance, particularly spatial memory performance, and/or social interaction in an infant or toddler and/or treating or preventing impaired or decreased exploratory behavior, memory performance, particularly spatial memory performance, and/or social interaction in an infant or toddler.

摘要翻译： 本发明涉及谷氨酰胺，优选以游离氨基酸，二肽和/或三肽的形式在制备用于改善探索行为，记忆性能，特别是空间记忆性能和/或社会相互作用的营养组合物中的用途 婴儿或幼儿和/或治疗或预防婴儿或幼儿的受损或减少的探索行为，记忆表现，特别是空间记忆性能和/或社交交互。

公开(公告)号：US20150366919A1

公开(公告)日：2015-12-24

申请号：US14440299

申请日：2013-11-04

申请人： N.V. NUTRICIA

发明人： Johan GARSSEN ,  Ruurd VAN ELBURG ,  Nana BARTKE ,  Aletta Desiree KRANEVELD

IPC分类号： A61K35/745 ,  A61K31/715 ,  A23L1/30 ,  A61K9/00 ,  A23L1/29 ,  A61K31/198 ,  A61K31/733

CPC分类号： A61K35/745 ,  A23L33/12 ,  A23L33/135 ,  A23L33/175 ,  A23L33/18 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23Y2300/29 ,  A61K9/009 ,  A61K31/198 ,  A61K31/202 ,  A61K31/702 ,  A61K31/715 ,  A61K31/733 ,  A61K45/06 ,  A61K2035/115 ,  A61K2300/00 ,  A23V2200/3202 ,  A23V2200/3204 ,  A23V2200/322

摘要： The invention relates to nutritional compositions with Bifidobacterium breve and non-digestible oligosaccharides selected from the group consisting of fructo-oligosaccharides, galacto-oligosaccharides, gluco-oligosaccharides, arabino-oligosaccharides, mannan-oligosaccharides, xylo-oligosaccharides, fuco-oligosaccharides, arabinogalacto-oligosaccharides, glucomanno-oligosaccharides, galactomanno-oligosaccharides, sialic acid comprising oligosaccharides and uronic acid oligosaccharides for use in improving cognitive or behavioral performance, cognitive or behavioral development, social interaction and/or neuroinflammation in infants or toddlers. Also claimed is the use of a nutritional compositions including Bifidobacterium breve, at least one non digestible oligosaccharide, glutamine in the form of free amino acids and/or glutamine containing dipeptide and/or glutaime containing tripeptide and LC-PUFA in the form or arachidonic acid and/or docosahexaenoic acid. Also claimed is a kit of parts comprising a first container comprising glutamine, and a non-digestible oligosaccharide and a second container comprising Bifidobacterium breve.

摘要翻译： 本发明涉及具有双歧杆菌和不消化的寡糖的营养组合物，其选自低聚果糖，低聚半乳糖，葡糖低聚糖，阿拉伯寡糖，甘露聚寡糖，低聚木糖，非低聚糖，阿拉伯半乳糖 - 寡糖，葡甘露寡糖，半乳寡糖低聚糖，包含寡糖的唾液酸和用于改善认知或行为表现，认知或行为发展，社会相互作用和/或婴儿或幼儿中的神经炎症的糖醛酸寡糖。 还要求保护的是使用包括双歧杆菌的营养组合物，至少一种不可消化的寡糖，游离氨基酸形式的谷氨酰胺和/或含有二肽和/或谷氨酰胺的含有三肽和/或戊糖酸的形式或花生四烯酸的LC-PUFA 和/或二十二碳六烯酸。 还要求保护的是一种试剂盒，其包含含有谷氨酰胺的第一容器和不消化的寡糖，以及包含短双歧杆菌的第二容器。

公开(公告)号：US20190289893A1

公开(公告)日：2019-09-26

申请号：US16435141

申请日：2019-06-07

申请人： N.V. Nutricia

发明人： Anniek Lidewij Schipper ,  Eline Marleen VAN DER BEEK ,  Dennis Stanley ACTON ,  Nana BARTKE ,  Stefanie SCHOEN

IPC分类号： A23L33/12 ,  A23L33/105 ,  A23L33/21 ,  A23L33/00

摘要： An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

公开(公告)号：US20170273343A1

公开(公告)日：2017-09-28

申请号：US15503930

申请日：2015-08-17

申请人： N.V. Nutricia

发明人： Annemiek Lidewij SCHIPPER ,  Eline Marleen VAN DER BEEK ,  Nana BARTKE

IPC分类号： A23L33/115 ,  A23C9/20 ,  A23L33/00

CPC分类号： A23L33/115 ,  A23C9/20 ,  A23C2240/05 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/18 ,  A23V2200/322 ,  A23V2250/184 ,  A23V2250/204

摘要： The present invention relates to a method for improving behaviour in a human subject, comprising administering a nutritional composition comprising 5-50 wt % vegetable lipids based on dry weight of the composition to the subject, the nutritional composition comprising lipid globules having (i) a volume-weighted mode diameter above 1.0 micrometer and/or (ii) a diameter of 2 to 12 micrometer in an amount of at least 45 volume % based on total lipid, wherein improving behaviour is selected from (a) increasing novel object recognition; (b) increasing the preference for novelty; (c) increasing the attention for surroundings; and (d) increasing exploratory behaviour and/or exploratory activity.