公开(公告)号：US11673925B2

公开(公告)日：2023-06-13

申请号：US17811302

申请日：2022-07-07

申请人： NANJING UNIVERSITY OF FINANCE AND ECONOMICS ,  NANJING UNIVERSITY OF CHINESE MEDICINE

发明人： Fang Wang ,  Xinchun Shen ,  Yong Fang ,  Zebin Weng

IPC分类号： C07K14/415 ,  A23L33/18 ,  A23L33/00 ,  A61P29/00 ,  A61K8/64 ,  A61Q19/00 ,  A61K38/00

CPC分类号： C07K14/415 ,  A23L33/18 ,  A23L33/40 ,  A61K8/645 ,  A61P29/00 ,  A61Q19/00 ,  A23V2002/00 ,  A61K38/00

摘要： An oligopeptide with anti-inflammatory activity, a preparation method, and an application thereof are provided, belonging to the field of biotechnology. An amino acid sequence of the oligopeptide is shown as SEQ ID NO:1. The preparation method includes: digesting a wheat germ protein through a simulated gastrointestinal tract to obtain protein digestion products; separating the protein digestion products by ultrafiltration membranes to obtain components I (>3 kDa), II (1˜3 kDa), and III (

公开(公告)号：US20240084357A1

公开(公告)日：2024-03-14

申请号：US18461604

申请日：2023-09-06

申请人： Nanjing University of Finance and Economics ,  Nanjing University of Chinese Medicine

发明人： Fang Wang ,  Xinchun Shen ,  Yong Fang ,  Zebin Weng

IPC分类号： C12P21/02 ,  C07K1/34

CPC分类号： C12P21/02 ,  C07K1/34

摘要： An oligopeptide with lipid-lowering activity, a preparation method and an application thereof are provided, belonging to the field of biotechnology. The amino acid sequence of the oligopeptide with lipid-lowering activity is shown in SEQ ID NO: 1. The preparation method includes the following steps: (1) hydrolyzing a loach protein with proteases to obtain an enzymatic hydrolysis product; (2) separating the enzymatic hydrolysis product using an ultrafiltration membrane, and taking a component with a molecular weight less than 3 kilodalton (kDa); and (3) filtering and separating the component with the molecular weight less than 3 kDa by Sephadex G-15 to obtain the oligopeptide. The oligopeptide is derived from the loach protein and has the characteristics of high safety, high efficiency, and wide sources.

公开(公告)号：US12077797B2

公开(公告)日：2024-09-03

申请号：US18461604

申请日：2023-09-06

申请人： Nanjing University of Finance and Economics ,  Nanjing University of Chinese Medicine

发明人： Fang Wang ,  Xinchun Shen ,  Yong Fang ,  Zebin Weng

IPC分类号： C07K1/34 ,  C12P21/02 ,  C12P21/06

CPC分类号： C12P21/02 ,  C07K1/34

摘要： An oligopeptide with lipid-lowering activity, a preparation method and an application thereof are provided, belonging to the field of biotechnology. The amino acid sequence of the oligopeptide with lipid-lowering activity is shown in SEQ ID NO: 1. The preparation method includes the following steps: (1) hydrolyzing a loach protein with proteases to obtain an enzymatic hydrolysis product; (2) separating the enzymatic hydrolysis product using an ultrafiltration membrane, and taking a component with a molecular weight less than 3 kilodalton (kDa); and (3) filtering and separating the component with the molecular weight less than 3 kDa by Sephadex G-15 to obtain the oligopeptide. The oligopeptide is derived from the loach protein and has the characteristics of high safety, high efficiency, and wide sources.