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公开(公告)号：US20240124409A1
公开(公告)日：2024-04-18
申请号：US18519062
申请日：2023-11-26
IPC分类号： C07D307/93 , A61P1/16 , A61P11/00 , A61P13/12 , A61P19/02 , A61P19/06 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： C07D307/93 , A61P1/16 , A61P11/00 , A61P13/12 , A61P19/02 , A61P19/06 , A61P29/00 , A61P31/00 , A61P35/00
摘要： The present application discloses a class of guaianolide sesquiterpene lactone derivatives and pharmaceutical use thereof. The guaianolide sesquiterpene lactone derivative or a pharmaceutically acceptable salt thereof is shown as general formula I. In the present application, a class of novel guaianolide sesquiterpene lactone derivatives are found by structural optimization with abundant natural ingredients such as parthenolide and dehydrocostus lactone as raw materials, which derivatives have good inhibitory activity on the activation of the NLRP3 inflammasome, and the chemical stability, water solubility and oral bioavailability of which are significantly improved, and it is verified by experiments that the derivatives have inhibitory effects on the activity of the NLRP3 inflammasome and have potential pharmaceutical applications.
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公开(公告)号：US20240084357A1
公开(公告)日：2024-03-14
申请号：US18461604
申请日：2023-09-06
发明人： Fang Wang , Xinchun Shen , Yong Fang , Zebin Weng
摘要： An oligopeptide with lipid-lowering activity, a preparation method and an application thereof are provided, belonging to the field of biotechnology. The amino acid sequence of the oligopeptide with lipid-lowering activity is shown in SEQ ID NO: 1. The preparation method includes the following steps: (1) hydrolyzing a loach protein with proteases to obtain an enzymatic hydrolysis product; (2) separating the enzymatic hydrolysis product using an ultrafiltration membrane, and taking a component with a molecular weight less than 3 kilodalton (kDa); and (3) filtering and separating the component with the molecular weight less than 3 kDa by Sephadex G-15 to obtain the oligopeptide. The oligopeptide is derived from the loach protein and has the characteristics of high safety, high efficiency, and wide sources.
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公开(公告)号：US20230086152A1
公开(公告)日：2023-03-23
申请号：US17998792
申请日：2021-12-14
发明人： Xu SHEN , Jiaying WANG , Yujie HUANG , Jian LU
IPC分类号： A61K31/4465 , A61P25/28
摘要： The present disclosure discloses a new use of desloratadine (DLT) and pharmaceutically acceptable salts thereof in preparing a drug for treating a neurodegenerative disease related to motor dysfunction. The present disclosure shows, through a large number of experimental tests, that desloratadine and the pharmaceutically acceptable salts thereof can improve the state of motor dysfunction in an SOD1-G93A model mouse in the behavioral experimental tests of Rotarod experimental test, gait monitoring experimental test and cage experimental test, and that desloratadine and the pharmaceutically acceptable salts thereof can effectively delay the onset time and prolong the survival cycle of the SOD1-G93A model mouse, and therefore, desloratadine and the pharmaceutically acceptable salts thereof can be used to treat neurodegenerative diseases related to motor dysfunction, including amyotrophic lateral sclerosis.
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4.发明授权公开(公告)号：US11673925B2
公开(公告)日：2023-06-13
申请号：US17811302
申请日：2022-07-07
发明人： Fang Wang , Xinchun Shen , Yong Fang , Zebin Weng
CPC分类号： C07K14/415 , A23L33/18 , A23L33/40 , A61K8/645 , A61P29/00 , A61Q19/00 , A23V2002/00 , A61K38/00
摘要： An oligopeptide with anti-inflammatory activity, a preparation method, and an application thereof are provided, belonging to the field of biotechnology. An amino acid sequence of the oligopeptide is shown as SEQ ID NO:1. The preparation method includes: digesting a wheat germ protein through a simulated gastrointestinal tract to obtain protein digestion products; separating the protein digestion products by ultrafiltration membranes to obtain components I (>3 kDa), II (1˜3 kDa), and III (
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公开(公告)号：US12077797B2
公开(公告)日：2024-09-03
申请号：US18461604
申请日：2023-09-06
发明人： Fang Wang , Xinchun Shen , Yong Fang , Zebin Weng
摘要： An oligopeptide with lipid-lowering activity, a preparation method and an application thereof are provided, belonging to the field of biotechnology. The amino acid sequence of the oligopeptide with lipid-lowering activity is shown in SEQ ID NO: 1. The preparation method includes the following steps: (1) hydrolyzing a loach protein with proteases to obtain an enzymatic hydrolysis product; (2) separating the enzymatic hydrolysis product using an ultrafiltration membrane, and taking a component with a molecular weight less than 3 kilodalton (kDa); and (3) filtering and separating the component with the molecular weight less than 3 kDa by Sephadex G-15 to obtain the oligopeptide. The oligopeptide is derived from the loach protein and has the characteristics of high safety, high efficiency, and wide sources.
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公开(公告)号：US20230266339A1
公开(公告)日：2023-08-24
申请号：US18040497
申请日：2020-11-26
发明人： Rui LIU , Shuo CAI , Mengtong JIANG , Kexuan ZHAO , Jinao DUAN
CPC分类号： G01N33/6887 , C07K14/78 , G01N30/88 , G01N30/7233 , G01N33/6848 , G01N2030/8831 , G01N2333/944
摘要： Disclosed are a deer-derived specific peptide and a detection method therefor; by screening through a large number of experiments, a ratio of relative contents of two deer-derived peptides is determined, and a graph is drawn by using a proportion of a deer antler gelatin in a mixed gelatin as an abscissa and using a value of Apeptide 1/Apeptide 2 as an ordinate; the proportion of the deer antler gelatin is linear with Apeptide 1/Apeptide 2 as a standard curve equation to distinguish a deer hide gelatin from the deer antler gelatin; the method can be used for distinguishing the deer antler gelatin from the deer hide gelatin, and controlling the quality; a defect in the prior art that the deer antler gelatin and the deer hide gelatin are difficult to distinguish in appearance, and are also difficult to distinguish by using a specific peptide fragment, is solved.
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7.发明公开公开(公告)号：US20240341311A1
公开(公告)日：2024-10-17
申请号：US18754225
申请日：2024-06-26
发明人： Jinao DUAN , Pei LIU , Hui YAN , Weimeng FENG , Sheng GUO , Sen ZHANG
CPC分类号： A01N63/22 , A01P21/00 , C12N1/205 , C12R2001/07
摘要： A strain separation method for preventing and controlling early bolting of Angelica sinensis, and preparation of a microbial agent and use thereof, the strain is obtained by separation, purification and cultivation from rhizosphere soil of Angelica sinensis, and is identified as Bacillus spp. by Microbial 16S rDNA sequencing; the strain was deposited at China Center for Type Culture Collection on Jun. 24, 2021 under CCTCC NO: M 2021767; The Bacillus velezensis XG3 strain provided by the present invention can promote the seed germination of Angelica sinensis and delay the flowering of Arabidopsis thaliana for about 2 days; according to field test verification, the microbial agent can increase the root weight, root diameter and rootlet number of Angelica sinensis, can effectively prevent and control early bolting of Angelica sinensis.
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公开(公告)号：US20210161929A1
公开(公告)日：2021-06-03
申请号：US17174266
申请日：2021-02-11
发明人： Shulan SU , Jinao DUAN , Dawei QIAN , Yue ZHU , Hui YAN , Xinxin DAI
IPC分类号： A61K31/7034 , A61P3/10 , A61P13/12
摘要： Disclosed is an application of verbascoside in the preparation of drugs for preventing and treating type II diabetic nephropathy. The protective effect of verbascoside on type II diabetic nephropathy and the action mechanism thereof are also included in the invention. The results show that verbascoside may improve liver injuries caused by high glucose, and reduce levels of serum creatinine, urea nitrogen, microalbuminuria and blood lipid (total cholesterol and triglyceride), fasting blood sugar and serum insulin in spontaneous diabetic db/db mice, and significantly reduce expressions of TGF-β1 and its signal transduction protein Smad3 and Smad4 and α-SMA in kidney tissues. Meanwhile, verbascoside may improve liver injuries caused by high glucose, and inhibit HK-2 proliferation and EMT formation. In conclusion, verbascoside induces significant protection on type II diabetic nephropathy, and its action mechanism is to protect kidney by regulating oxidative stress response, inhibiting TGF-β/smad signal pathways and improving renal fibrosis.
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公开(公告)号：US20240342225A1
公开(公告)日：2024-10-17
申请号：US18754218
申请日：2024-06-26
发明人： Jinao DUAN , Sheng GUO , Wanchen CUI , Haifeng LIU
IPC分类号： A61K35/741 , A61K36/815 , A61P1/00
CPC分类号： A61K35/741 , A61K36/815 , A61P1/00 , A61K2236/331 , A61K2236/333 , A61K2236/51
摘要： Disclosed in the present invention is a combined formulation capable of ameliorating gastrointestinal adverse effects caused by oxaliplatin, which comprises lycium barbarum polysaccharides and Akkermansia muciniphila; the lycium barbarum polysaccharide is obtained by removing small molecular substances by ethanol extraction, then continuously performing reflux extraction by using water, and separating by using a hollow fiber ultrafiltration device; Akkermansia muciniphila is Akkermansia muciniphila ATCC BAA835; the combined formulation provided by the present invention can ameliorate intestinal injury, reduce inflammatory factors and maintain intestinal barriers, and thus can be used as a functional food or a medicine to ameliorate gastrointestinal adverse effects caused by oxaliplatin.
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10.发明申请公开(公告)号：US20230008335A1
公开(公告)日：2023-01-12
申请号：US17811302
申请日：2022-07-07
发明人： FANG WANG , Xinchun Shen , Yong Fang , Zebin Weng
摘要： An oligopeptide with anti-inflammatory activity, a preparation method, and an application thereof are provided, belonging to the field of biotechnology. An amino acid sequence of the oligopeptide is shown as SEQ ID NO:1. The preparation method includes: digesting a wheat germ protein through a simulated gastrointestinal tract to obtain protein digestion products; separating the protein digestion products by ultrafiltration membranes to obtain components I (>3 kDa), II (1˜3 kDa), and III (
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