公开(公告)号：US20150265731A1

公开(公告)日：2015-09-24

申请号：US14254365

申请日：2014-04-16

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  NATIONAL CANCER CENTER

Inventor： Yoonkyung KIM ,  Ju Young HEO ,  June-key CHUNG ,  Young-Hwa KIM ,  Seok Ki KIM ,  Se Hun KANG

IPC: A61K51/08

CPC classification number: A61K49/0002 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K51/065 ,  A61K51/082

Abstract: Disclosed herein is a method of improving tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting, and the multivalent ligands for tumor diagnosis.

Abstract translation: 本文公开了通过调节用于肿瘤靶向的内表面官能团和配体部分之间的化学计量比和用于肿瘤诊断的多价配体来提高多价配体的肿瘤诊断效率的方法。

公开(公告)号：US20210369875A1

公开(公告)日：2021-12-02

申请号：US17290906

申请日：2019-11-01

Applicant: National Cancer Center

Inventor： Yong Doo CHOI ,  Seon Sook LEE ,  Hyun Jin KIM ,  Dae Kyung SOHN ,  Seok Ki KIM ,  Young Woo KIM ,  Keun Won RYU ,  Hong Man YOON

IPC: A61K49/00 ,  A61K49/18 ,  A61K45/06

Abstract: The present invention provides an alginic acid-based injectable hydrogel system for labeling an accurate position of a disease lesion and effectively delivering a drug to a target region. The formulation of the present invention can make it easy to locally inject a contrast agent and a drug into a target region while controlling the release rate of the contrast agent or the drug, with the formation of the hydrogel in the injected region. Through the advantages, the labeled position can be accurately determined from images, thereby enhancing the precision of surgical operation, with a minimal incision formed therefor. In addition, when used, the alginic acid-based injectable hydrogel system allows the effective local delivery of a drug to a target region while increasing the long-acting effect of the drug.

公开(公告)号：US20190111158A1

公开(公告)日：2019-04-18

申请号：US16094037

申请日：2017-04-21

Applicant: NATIONAL CANCER CENTER

Inventor： Seok Ki KIM ,  Insoo PARK ,  Jin Hee NOH

IPC: A61K49/00 ,  A61K51/08

Abstract: The present invention relates to an injectable composition for labeling a lesion and a method for providing information on the position of the lesion using the injectable composition. More specifically, the injectable composition for labeling a lesion according to the present invention can include a second composition comprising a biocompatible viscous material in a first composition comprising a complex containing an active ingredient to resolve a problem of rapid settling of the complex. Additionally, in particular, the injection composition for labeling a lesion according to the present invention can have an effect of allowing a predetermined amount of the complex to be injected by resolving the problem of rapid settling of the complex during preparation of the injection, allowing a certain amount of the complex to be injected, and an effect of enabling convenient and stable use thereof for clinical purposes by resolving the problems of injecting an excessive amount of the complex and the quick spread thereof to the periphery.

公开(公告)号：US20180042692A1

公开(公告)日：2018-02-15

申请号：US15556945

申请日：2016-02-01

Applicant: NATIONAL CANCER CENTER

Inventor： Seok Ki KIM ,  Seong Cheon KIM ,  Sun Up PARK

IPC: A61B90/00 ,  A61B1/313 ,  A61B1/04

Abstract: The present disclosure relates to an augmented reality (AR) image projection system capable of simultaneously capturing a real image and projecting an AR image, and capable of applying same to a subject requiring precise work or in an environment having spatial restrictions. The present disclosure includes a real image capture device for capturing a real image illuminated by invisible rays without interference with visible rays, and an AR image projection device for projecting an AR image, wherein the real image capture device captures a real image and the AR image projection device projects an AR image through the same optical axis. Further, the present disclosure includes a real image capture device, an AR image projection device, as well as additional imaging devices such as a fluorescent camera configured integrally along the same optical axis, and configured to avoid wavelength interference between a light source and an excitation light and the like.

公开(公告)号：US20180052107A1

公开(公告)日：2018-02-22

申请号：US15553858

申请日：2016-01-29

Applicant: NATIONAL CANCER CENTER

Inventor： Seok Ki KIM ,  Seong Cheon KIM ,  Sun Up PARK

IPC: G01N21/64 ,  G01N21/17 ,  A61B1/06 ,  G06T7/90

CPC classification number: G01N21/6456 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  A61B5/0071 ,  A61B5/0084 ,  G01J3/10 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/106 ,  G01N21/17 ,  G01N2021/1736 ,  G01N2021/174 ,  G01N2021/6417 ,  G01N2021/6471 ,  G06T7/90 ,  G06T2207/10064

Abstract: The present invention relates to a fluorescent image system capable of generating white light by mixing three monochromatic lights, i.e. red, green and blue monochromatic lights, having a narrow band wavelength, instead of white light of constant wavelength; providing a fluorescent image-use light source that generates a mixed light by adding a fluorescent excitation light source suitable for fluorescent substances; and photographing a general image and fluorescent image simultaneously with the light sources. The fluorescent image system includes a monochromatic light source to generate white light by mixing red, green and blue monochromatic lights, and a fluorescent excitation light source for fluorescent images; and includes a mixed light source to provide a mixed light which mixes monochromatic light and fluorescent light, and an image photographing device which separates the wavelengths of visible light and fluorescent light in the mixed light, and photographs a general image, fluorescent image and mixed image.

公开(公告)号：US20150328345A1

公开(公告)日：2015-11-19

申请号：US14758179

申请日：2013-12-04

Applicant: NATIONAL CANCER CENTER

Inventor： Seok Ki KIM ,  Se Hun KANG ,  Seok Won KIM ,  So Youn JUNG

IPC: A61K51/08 ,  A61K49/00

CPC classification number: A61K51/081 ,  A61K49/0056 ,  A61K49/006 ,  G01N33/574 ,  G01N33/58 ,  G01N2333/765

Abstract: The present invention relates to a labeling composition for a cancer lesion, having a complex in which a pigment for straining living tissues, a radioactive isotope, or a combination thereof binds to macro aggregated albumin (MAA). A method for providing information regarding a cancer lesion site using the labeling composition for a cancer lesion. A labeling kit for a cancer lesion having the labeling composition for a cancer lesion; and a complex in which a pigment for straining living tissues binds to MAA included in the labeling composition for a cancer lesion. The labeling composition for a cancer lesion according to the present invention binds to a cancer lesion to detect a site, size, and the like of the cancer lesion in real time, thereby improving the success rate of a surgical operation for the cancer lesion and also preventing excessive loss of normal tissues.

Abstract translation: 本发明涉及一种癌症病变标记组合物，其具有将活体组织，放射性同位素或其组合的颜料与宏观聚集白蛋白（MAA）结合的复合物。 使用癌症病变的标记组合物提供关于癌症病变部位的信息的方法。 用于癌症病变的标记试剂盒，其具有癌症病变的标记组合物; 以及其中用于使活组织变性的颜料与包括在癌症病变的标记组合物中的MAA结合的复合物。 根据本发明的癌症病变的标记组合物结合癌症病变以实时检测癌症病变的部位，大小等，从而提高癌症病变的外科手术的成功率，并且还 防止正常组织的过度损失。