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公开(公告)号：US20160333113A1
公开(公告)日：2016-11-17
申请号：US15111875
申请日：2015-02-03
发明人： Yasuhiro MATSUMURA , Masahiro YASUNAGA , Yoshikatsu KOGA , Yoshiyuki YAMAMOTO , Ryuta SATO , Ryo TSUMURA , Kazunori KATAOKA , Nobuhiro NISHIYAMA , Yutaka MIURA , Shino MANABE , Yasuki KATO
IPC分类号： C07K16/36 , A61K47/48 , A61K39/395
CPC分类号： C07K16/36 , A61K39/3955 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies against human and mouse tissue factor, and fragments thereof, are disclosed, as well as pharmaceutical compositions and compositions for drug delivery containing the same. Therapeutic methods using the same are also disclosed.
摘要翻译： 公开了针对人和小鼠组织因子的单克隆抗体及其片段，以及含有其的药物组合物和用于药物递送的组合物。 还公开了使用其的治疗方法。
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公开(公告)号：US20180042955A1
公开(公告)日：2018-02-15
申请号：US15725703
申请日：2017-10-05
发明人： Kazunori KATAOKA , Kanjiro MIYATA , Nobuhiro NISHIYAMA , Kensuke OSADA , Sumiyo WATANABE , Shigeto FUKUSHIMA , Hiroyuki CHAYA , Hiroyasu TAKEMOTO , Yasuki KATO
IPC分类号： A61K31/713 , A61K47/60 , A61K47/64 , A61K9/00
CPC分类号： A61K31/713 , A61K9/0019 , A61K47/60 , A61K47/64 , A61K47/645 , A61K47/6455 , A61K48/00
摘要： A unit structure-type pharmaceutical composition includes a single nucleic acid, such as an antisense nucleic acid, electrostatically bound to a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charges of the nucleic acid are counterbalanced, at least substantially, by the positive charges of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment. The block copolymer thereby improves the blood retention capability of the nucleic acids.
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公开(公告)号：US20180153920A1
公开(公告)日：2018-06-07
申请号：US15879821
申请日：2018-01-25
发明人： Kazunori KATAOKA , Kanjiro MIYATA , Nobuhiro NISHIYAMA , Kensuke OSADA , Sumiyo WATANABE , Shigeto FUKUSHIMA , Hiroyuki CHAYA , Hiroyasu TAKEMOTO , Yasuki KATO
IPC分类号： A61K31/713 , A61K47/64 , A61K47/60 , A61K9/00
CPC分类号： A61K31/713 , A61K9/0019 , A61K47/60 , A61K47/645 , A61K47/6455 , C08G69/10
摘要： A unit structure consists of a single nucleic acid having a length of 10 to 30 bases, and a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. In this unit structure: (i) a difference between a total of positive charges derived from cationic groups of the cationic polyamino acid segment and a total of negative charges derived from the nucleic acid in the unit structure falls within a range of ±10% of the total of the negative charges derived from the nucleic acid, (ii) the hydrophilic polymer chain segment comprises polyethylene glycol, (iii) the polyethylene glycol has a radius of inertia (Rg) equal to or longer than the length of the nucleic acid, and (iv) the cationic polyamino acid segment is bound to the nucleic acid via electrostatic bonds.
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公开(公告)号：US20180334674A1
公开(公告)日：2018-11-22
申请号：US15777498
申请日：2016-11-18
IPC分类号： C12N15/113 , A61P35/00 , A61K9/107 , A61K47/69 , A61K47/60 , A61K47/64 , A61K31/713
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/127 , A61K31/7088 , A61K31/713 , A61K35/76 , A61K47/34 , A61K47/60 , A61K47/6455 , A61K47/6907 , A61K48/00 , A61P35/00 , C12N15/00 , C12N2310/111 , C12N2310/14 , C12N2310/3231 , C12N2310/351 , C12N2310/3513 , C12N2320/32
摘要： This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.
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公开(公告)号：US20180185281A1
公开(公告)日：2018-07-05
申请号：US15740987
申请日：2016-07-01
发明人： Kazunori KATAOKA , Yasutaka ANRAKU , Mao HORI
CPC分类号： A61K9/1075 , A61K9/0085 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/34 , A61K47/42 , A61P25/16 , A61P25/28 , C08G65/08 , C08G65/33396 , C08G69/36 , C08G69/48 , C08G81/00
摘要： The present invention provides a carrier containing a first block copolymer and a second block copolymer, wherein the first block copolymer is a block copolymer of a first non-charged segment and a first complex-forming segment, at least some proportion of said first block copolymer is modified by a first molecule, the second block copolymer is a block copolymer of a second non-charged segment and a second complex-forming segment, and wherein at least some proportion of said second block copolymer is modified by a second molecule, said first molecule is a GLUT1 ligand, and said second molecule is different from the first molecule.
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6.发明申请POLYMER NANOPARTICLE COMPOSITE AND COMPOSITION FOR MRI IMAGING INCLUDING SAME 有权聚合物纳米复合材料和用于MRI成像的组合物，包括它们公开(公告)号：US20160206759A1
公开(公告)日：2016-07-21
申请号：US14913903
申请日：2014-08-22
发明人： Kazunori KATAOKA , Nobuhiro NISHIYAMA , Horacio CABRAL , Peng MI , Akihiro KISHIMURA , Yutaka MIURA , Ichio AOKI , Daisuke KOKURYO , Tsuneo SAGA
CPC分类号： A61K49/1872 , A61K9/14 , A61K9/143 , A61K49/128 , A61K49/1818 , A61K49/1824 , A61K49/1851 , A61K49/1866 , C08K3/32
摘要： The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.
摘要翻译： 本发明提供了具有很少副作用的安全聚合物纳米颗粒复合材料，以及掺入所述聚合物纳米颗粒复合材料的MRI造影剂。 聚合物纳米颗粒复合物能够特异性地积聚在肿瘤组织上以选择性地提取组织，即使在少量使用时也显示出高对比度，并且能够在长时间内成像。 该聚合物纳米颗粒复合材料的特征在于含有包含无电荷的亲水聚合物链段和阴离子聚合物链段的嵌段共聚物和MnCaP。
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公开(公告)号：US20150087601A1
公开(公告)日：2015-03-26
申请号：US14531301
申请日：2014-11-03
IPC分类号： A61K41/00
CPC分类号： A61K41/0042 , A61K9/5146 , A61K47/34 , A61K48/00 , C08G73/0233 , C08G73/028 , C12N15/87 , C12N15/88
摘要： It is an object of the present invention to provide: a polyion complex that sufficiently retains a photosensitizing substance in serum and is excellent in terms of structural stability; a nucleic acid polyplex as a constituent thereof; and a device and a kit for delivering a nucleic acid into a cell.The nucleic acid polyplex of the present invention comprises a cationic polymer represented by general formula (1) and a nucleic acid. The polyion complex of the present invention comprises the nucleic acid polyplex of the present invention and an anionic photosensitizing substance.
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公开(公告)号：US20180140680A1
公开(公告)日：2018-05-24
申请号：US15571217
申请日：2016-05-06
CPC分类号： A61K38/46 , A61K9/127 , A61K47/42 , A61P35/00 , C12Y302/0102
摘要： The present invention provides a nanoreactor (nano size reaction field) using a polyion complex polymersome and a method for producing the nanoreactor. The present invention provides a polyion complex polymersome encapsulating e.g., an enzyme, in which the enzyme is an enzyme acting on a substance passing through a membrane of the polyion complex polymersome, as a substrate.
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公开(公告)号：US20210346472A1
公开(公告)日：2021-11-11
申请号：US17380226
申请日：2021-07-20
摘要： The present invention provides a nanoreactor (nano size reaction field) using a polyion complex polymersome and a method for producing the nanoreactor. The present invention provides a polyion complex polymersome encapsulating e.g., an enzyme, in which the enzyme is an enzyme acting on a substance passing through a membrane of the polyion complex polymersome, as a substrate.
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公开(公告)号：US20210346290A1
公开(公告)日：2021-11-11
申请号：US17251521
申请日：2019-06-13
发明人： Yasutaka ANRAKU , Kazunori KATAOKA , Shigeto FUKUSHIMA , Kanjiro MIYATA , Hyun Su MIN , Mitsuru NAITO
IPC分类号： A61K9/107 , A61K31/7088 , A61K47/34 , A61K9/00 , A61P3/08
摘要： The present invention provides a polyion complex micelle including an antisense oligonucleotide and a block copolymer of a cationic polymer and a PEG block having a number average molecular weight of 3 kDa to 10 kDa.
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