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公开(公告)号：US09920133B2
公开(公告)日：2018-03-20
申请号：US15111875
申请日：2015-02-03
发明人： Yasuhiro Matsumura , Masahiro Yasunaga , Yoshikatsu Koga , Yoshiyuki Yamamoto , Ryuta Sato , Ryo Tsumura , Kazunori Kataoka , Nobuhiro Nishiyama , Yutaka Miura , Shino Manabe , Yasuki Kato
IPC分类号： C07K16/36 , A61K47/48 , A61K39/395 , A61K39/00
CPC分类号： C07K16/36 , A61K39/3955 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies against human and mouse tissue factor, and fragments thereof, are disclosed, as well as pharmaceutical compositions and compositions for drug delivery containing the same. Therapeutic methods using the same are also disclosed.
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公开(公告)号：US11633499B2
公开(公告)日：2023-04-25
申请号：US16083077
申请日：2017-03-07
发明人： Yasuhiro Matsumura , Masahiro Yasunaga , Shinji Saijou , Shingo Hanaoka , Takahiro Anzai , Shino Manabe
IPC分类号： G01N33/574 , C07K16/30 , A61K47/68 , C12N15/09 , C12N5/10 , A61K39/395 , A61K49/00 , A61P35/00 , C12N15/62
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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公开(公告)号：US20200078458A1
公开(公告)日：2020-03-12
申请号：US16578861
申请日：2019-09-23
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30 , A61K39/00 , C07K16/18
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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公开(公告)号：US11377504B2
公开(公告)日：2022-07-05
申请号：US16760539
申请日：2018-10-29
摘要： The present invention provides an antibody beneficial for treatment of a solid tumor, an antibody-drug conjugate thereof, and an anticancer agent comprising these. The present invention provides, for example, an antibody that binds to tissue factor or an antigen-binding fragment thereof, wherein the antibody has a dissociation rate constant kd of 5×10−4 s−1 or more and an association rate constant Ka of 1×104 M−1 s−1 or more.
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公开(公告)号：US11192956B2
公开(公告)日：2021-12-07
申请号：US16325315
申请日：2017-08-14
IPC分类号： C07K16/30 , A61P43/00 , A61K45/00 , G01N33/53 , G01N33/574 , A61P35/00 , A61K39/395 , C07K16/28 , A61K47/68 , C12N15/09
摘要： [Problem]
The present invention provides an antibody that binds to TMEM132A, an anticancer agent and a cancer test method.
[Solution]
An antibody that binds to TMEM132A.-
公开(公告)号：US09429584B2
公开(公告)日：2016-08-30
申请号：US14770864
申请日：2014-02-27
CPC分类号： G01N33/86 , A61K47/6843 , C07K16/18 , C07K16/36 , C07K2317/33 , C07K2317/34 , G01N2333/75 , G01N2800/226
摘要： With the intention of providing an antibody which does not bind to fibrinogen and which has a high affinity for and a high specificity to insoluble fibrin, it is found that a site comprising the amino acids at positions 231 to 246 of the fibrinogen Bβ chain and a site comprising the amino acids at positions 232 to 246 of the fibrinogen γ chain are bound to each other in a fibrinogen molecule. Further, it is shown that when fibrinogen is converted to insoluble fibrin, the binding is released, and these sites are exposed. It is also found that antibodies obtained by immunization with these sites do not bind to fibrinogen and have high affinity for and high specificity to insoluble fibrin.
摘要翻译： 为了提供不与纤维蛋白原结合并且对不溶性纤维蛋白具有高亲和力和高特异性的抗体，发现包含纤维蛋白原Bβ链的第231至246位的氨基酸的位点和 包含纤维蛋白原γ链的第232至246位的氨基酸的位点在纤维蛋白原分子中彼此结合。 此外，显示当纤维蛋白原转化为不溶性纤维蛋白时，释放结合，并暴露这些部位。 还发现通过用这些位点进行免疫获得的抗体不结合纤维蛋白原并且对不溶性纤维蛋白具有高亲和力和高特异性。
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公开(公告)号：US20240148893A1
公开(公告)日：2024-05-09
申请号：US18178854
申请日：2023-03-06
发明人： Yasuhiro MATSUMURA , Masahiro Yasunaga , Shinji Saijou , Shingo Hanaoka , Takahiro Anzai , Shino Manabe
IPC分类号： A61K47/68 , A61K39/395 , A61K49/00 , A61P35/00 , C07K16/30 , C12N5/10 , C12N15/09 , C12N15/62 , G01N33/574
CPC分类号： A61K47/6851 , A61K39/395 , A61K49/00 , A61P35/00 , C07K16/30 , C12N5/10 , C12N15/09 , C12N15/62 , G01N33/574 , G01N33/57419
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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8.发明授权公开(公告)号：US11524074B2
公开(公告)日：2022-12-13
申请号：US16578861
申请日：2019-09-23
IPC分类号： A61K39/395 , C07K16/30 , C07K16/18 , G01N33/574 , A61K39/00
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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公开(公告)号：US10471146B2
公开(公告)日：2019-11-12
申请号：US15509269
申请日：2015-09-08
IPC分类号： A61K39/395 , G01N33/577 , C07K16/30 , C12N15/13 , C07K16/18 , G01N33/574 , A61K39/00
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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公开(公告)号：US20170260284A1
公开(公告)日：2017-09-14
申请号：US15509269
申请日：2015-09-08
IPC分类号： C07K16/30 , A61K39/00 , G01N33/574 , A61K39/395
摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.
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