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    Use of L. reuteri for recovery of microbiota dysbiosis in early life
    2.
    发明授权
    Use of L. reuteri for recovery of microbiota dysbiosis in early life 有权

    公开(公告)号：US11369646B2

    公开(公告)日：2022-06-28

    申请号：US15521977

    申请日：2015-10-29

    申请人： NESTEC S.A.

    发明人： Clara Lucia Garcia-Rodenas ,  Bernard Berger ,  Catherine Ngom-Bru ,  Melissa Lepage ,  Tara Neville

    IPC分类号： A61K35/747 ,  A23L33/00 ,  A23L33/135 ,  A61K35/745 ,  A61K31/702 ,  A61K31/733 ,  A61K45/06 ,  A61K9/00

    摘要： The invention concerns Lactobacillus reuteri for use in the prevention or treatment of microbiota dysbiosis, in particular, decreased levels of Actinobacteria and increased levels of Proteobacteria, in young mammals and in the prevention or treatment of disorders associated therewith. The microbiota dysbiosis may have been cause by numerous factors including being born by caesarean section, exposure to antibiotics in utero or after birth, or, parenteral feeding, hospitalizing, psychological stress or by gastrointestinal dysfunctions. The disorders that may be treated or prevented by preventing or treating microbiota dysbiosis include propensity to infection, allergy, type I diabetes mellitus, insulin resistance, type 2 diabetes, celiac disease, peripheral and central adiposity, obesity, necrotizing enterocolitis, inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, and functional gastrointestinal disorders such as IBS, functional diarrhea, functional constipation, recurrent abdominal pain, and dyspepsia.