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公开(公告)号：US20210038766A1
公开(公告)日：2021-02-11
申请号：US16757191
申请日：2018-10-19
发明人： Tony Chen , Suzanne A. Maher , Russell Warren
摘要： An improved method of making, manufacturing and/or producing engineered orthopedic soft tissue including cartilage, meniscus, annulus fibrosus, and tendon/ligaments which results in engineered soft tissue in which the fibers are aligned the same or nearly the same as naturally occurring tissue. The present invention also includes molds and other apparatus for carrying out the methods of the invention and kits.
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2.发明申请公开(公告)号：US20170209624A1
公开(公告)日：2017-07-27
申请号：US15370832
申请日：2016-12-06
IPC分类号： A61L27/56 , A61F2/38 , A61F2/44 , B29C70/70 , A61L27/54 , A61F2/08 , A61F2/28 , A61L27/52 , A61L27/16 , A61F2/30 , B29C71/02
CPC分类号： A61L27/56 , A61B17/1675 , A61F2/0811 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/3872 , A61F2/442 , A61F2002/0817 , A61F2002/0858 , A61F2002/087 , A61F2002/0888 , A61F2002/30075 , A61F2210/0061 , A61L27/16 , A61L27/18 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , B29C70/70 , B29C71/02 , B29K2029/04 , B29K2105/0061 , B29K2995/006 , B29L2031/7532 , C08L75/04 , C08L71/02 , C08L29/04 , C08L39/06 , C08L33/26
摘要： An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.
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3.发明授权Multi-component non-biodegradable implant, a method of making and a method of implantation 有权多组分不可生物降解植入物，制备方法和植入方法公开(公告)号：US09545310B2
公开(公告)日：2017-01-17
申请号：US14261821
申请日：2014-04-25
IPC分类号： A61F2/30 , B29C70/70 , A61F2/38 , A61F2/28 , A61F2/44 , A61L27/16 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/56 , A61F2/08 , A61B17/16
CPC分类号： A61L27/56 , A61B17/1675 , A61F2/0811 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/3872 , A61F2/442 , A61F2002/0817 , A61F2002/0858 , A61F2002/087 , A61F2002/0888 , A61F2002/30075 , A61F2210/0061 , A61L27/16 , A61L27/18 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , B29C70/70 , B29C71/02 , B29K2029/04 , B29K2105/0061 , B29K2995/006 , B29L2031/7532 , C08L75/04 , C08L71/02 , C08L29/04 , C08L39/06 , C08L33/26
摘要： An implant having at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.
摘要翻译： 具有至少三个组分的植入物，即固体水凝胶，邻近或环绕固体水凝胶的多孔水凝胶（一起被认为是“水凝胶”）和多孔刚性基质。 固体水凝胶和多孔刚性基底承载接头负载，多孔水凝胶层和多孔刚性基底允许细胞迁移到植入物中和周围。 本发明还是一种制造植入物的新方法，植入植入物的新方法，以及用植入物治疗，修复或替代生物组织，更优选肌肉骨骼组织的方法。
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公开(公告)号：US11040124B2
公开(公告)日：2021-06-22
申请号：US16498211
申请日：2018-05-01
发明人： Suzanne A. Maher , Tony Chen , Russell Warren
IPC分类号： B29C45/03 , A61L27/52 , A61L27/16 , A61L27/56 , A61L27/58 , B29C45/00 , B29C45/14 , B29C45/16 , B29C45/26 , B29C45/72 , B29K29/00 , B29K105/00 , B29K105/04
摘要： An improved new method of making a multi-component implant comprising a solid hydrogel, a porous hydrogel, and a porous rigid base suitable for implantation into a mammal, to treat, repair or replace defects and/or injury biological tissue as well as the implant made from the improved method. The invention also includes an improved method for making devices, constructs, and materials comprising a hydrogel and a porous rigid material. The invention also includes a mold and kits for performing the methods.
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5.发明授权公开(公告)号：US10583224B2
公开(公告)日：2020-03-10
申请号：US15370832
申请日：2016-12-06
IPC分类号： A61F2/30 , A61L27/56 , B29C70/70 , A61F2/38 , A61F2/28 , A61F2/44 , A61F2/08 , A61L27/16 , A61L27/18 , A61L27/52 , A61L27/54 , B29C71/02 , A61B17/16 , B29K29/00 , B29K105/00 , B29L31/00
摘要： An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.
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6.发明申请MULTI-COMPONENT NON-BIODEGRADABLE IMPLANT, A METHOD OF MAKING AND A METHOD OF IMPLANTATION 有权多组分非生物降解植入物，制造方法和植入方法公开(公告)号：US20140324169A1
公开(公告)日：2014-10-30
申请号：US14261821
申请日：2014-04-25
CPC分类号： A61L27/56 , A61B17/1675 , A61F2/0811 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/3872 , A61F2/442 , A61F2002/0817 , A61F2002/0858 , A61F2002/087 , A61F2002/0888 , A61F2002/30075 , A61F2210/0061 , A61L27/16 , A61L27/18 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , B29C70/70 , B29C71/02 , B29K2029/04 , B29K2105/0061 , B29K2995/006 , B29L2031/7532 , C08L75/04 , C08L71/02 , C08L29/04 , C08L39/06 , C08L33/26
摘要： An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.
摘要翻译： 植入物包括至少三种组分，即固体水凝胶，邻近或环绕固体水凝胶的多孔水凝胶（一起被认为是“水凝胶”），以及多孔刚性基底。 固体水凝胶和多孔刚性基底承载接头负载，多孔水凝胶层和多孔刚性基底允许细胞迁移到植入物中和周围。 本发明还是一种制造植入物的新方法，植入植入物的新方法，以及用植入物治疗，修复或替代生物组织，更优选肌肉骨骼组织的方法。
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