-
公开(公告)号：US09855338B2
公开(公告)日：2018-01-02
申请号：US15354547
申请日：2016-11-17
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
IPC分类号： A61K31/00 , A61K47/42 , A61K49/00 , A61K31/337 , A61K49/14 , A61K31/704 , A61K31/4745 , A61K47/62 , A61K47/64 , A61K47/56
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
-
公开(公告)号：US09839694B2
公开(公告)日：2017-12-12
申请号：US14786729
申请日：2013-04-26
发明人： Kwok Yin Tsang , Hao Bai , Yi Jin , Lei Yu
IPC分类号： C08G69/00 , A61K47/48 , A61K31/337 , C08G69/10 , C08G69/46 , C08G69/48 , A61K47/59 , A61K47/64
CPC分类号： A61K47/645 , A61K31/337 , A61K47/595 , C08G69/10 , C08G69/46 , C08G69/48
摘要： Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.
-
公开(公告)号：US20130295039A1
公开(公告)日：2013-11-07
申请号：US13791137
申请日：2013-03-08
发明人： Seiji Nukui , Kwok Yin Tsang , Chunfeng Yin , Yi Jin , Lei Yu
IPC分类号： A61K47/48
CPC分类号： A61K47/48207 , A61K47/645
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可以包括可包含药物的化合物的连接体的聚谷氨酸氨基酸缀合物及其用于各种药物递送的用途 应用，例如抗癌。
-
公开(公告)号：US20130272993A1
公开(公告)日：2013-10-17
申请号：US13790995
申请日：2013-03-08
发明人： Kwok Yin Tsang , Hai Wang , Hao Bai , Yi Jin , Lei Yu
IPC分类号： A61K47/48
CPC分类号： A61K47/48207 , A61K47/645 , A61K49/146 , C08G69/10
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。
-
5.发明申请公开(公告)号：US20160074524A1
公开(公告)日：2016-03-17
申请号：US14786841
申请日：2013-04-26
发明人： Hao Bai , Kwok Yin Tsang , Yi Jin , Lei Yu
CPC分类号： A61K47/48207 , A61K47/645 , C08G69/10 , C08G73/028
摘要： Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.
摘要翻译： 本文描述了制备生物相容性水溶性聚合物共轭物的方法。 特别地，本文描述了可用于各种药物递送应用的制备聚（L-γ-谷氨酸 - 谷氨酸）共轭物的大规模方法。
-
公开(公告)号：US09295728B2
公开(公告)日：2016-03-29
申请号：US13790995
申请日：2013-03-08
发明人： Kwok Yin Tsang , Hai Wang , Hao Bai , Yi Jin , Lei Yu
CPC分类号： A61K47/48207 , A61K47/645 , A61K49/146 , C08G69/10
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。
-
公开(公告)号：US20160058877A1
公开(公告)日：2016-03-03
申请号：US14786729
申请日：2013-04-26
申请人： Kwok Yin TSANG , Hao BAI , Yi JIN , Lei YU , NITTO DENKO CORPORATION
发明人： Kwok Yin Tsang , Hao Bai , Yi Jin , Lei Yu
IPC分类号： A61K47/48 , A61K31/337 , C08G73/02
CPC分类号： A61K47/645 , A61K31/337 , A61K47/595 , C08G69/10 , C08G69/46 , C08G69/48
摘要： Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.
摘要翻译： 本文描述的是降低聚阴离子聚合物缀合物的内毒素含量的方法。 特别地，本文描述了可以用于多种药物递送应用的聚阴离子聚合物缀合物中降低内毒素含量的方法。
-
公开(公告)号：US09078926B2
公开(公告)日：2015-07-14
申请号：US13791137
申请日：2013-03-08
发明人： Seiji Nukui , Kwok Yin Tsang , Chunfeng Yin , Yi Jin , Lei Yu
IPC分类号： A61K31/045 , A61K31/337 , A61K31/40 , A61K38/02 , A61K47/34 , A61K47/48
CPC分类号： A61K47/48207 , A61K47/645
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可以包括可包含药物的化合物的连接体的聚谷氨酸氨基酸缀合物及其用于各种药物递送的用途 应用，例如抗癌。
-
公开(公告)号：US09636411B2
公开(公告)日：2017-05-02
申请号：US14786841
申请日：2013-04-26
发明人： Hao Bai , Kwok Yin Tsang , Yi Jin , Lei Yu
CPC分类号： A61K47/48207 , A61K47/645 , C08G69/10 , C08G73/028
摘要： Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.018 秒)