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公开(公告)号：US20190127318A1
公开(公告)日：2019-05-02
申请号：US16228054
申请日：2018-12-20
发明人： Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号： C07C271/16 , A61K31/713 , C07F9/10 , C07D211/82 , C07D211/86 , C07D207/09 , C07D207/12 , C07D205/04 , C07F9/06 , C07C237/16 , C07C237/50 , C07C237/08 , A61K9/51 , A61K9/127 , A61K47/22 , A61K47/16 , A61K47/24 , A61K31/7105 , C07D211/74
摘要： This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号：US20130272993A1
公开(公告)日：2013-10-17
申请号：US13790995
申请日：2013-03-08
发明人： Kwok Yin Tsang , Hai Wang , Hao Bai , Yi Jin , Lei Yu
IPC分类号： A61K47/48
CPC分类号： A61K47/48207 , A61K47/645 , A61K49/146 , C08G69/10
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。
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公开(公告)号：US20160376229A1
公开(公告)日：2016-12-29
申请号：US15191511
申请日：2016-06-23
发明人： Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Ying , Wenbin Ying
IPC分类号： C07C271/16 , A61K47/22 , C07D207/12 , A61K47/16 , C07C237/16 , A61K31/713 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , A61K47/24 , C07D205/04 , C07D207/09
CPC分类号： C07C271/16 , A61K9/127 , A61K9/5123 , A61K31/7105 , A61K31/713 , C07C237/08 , C07C237/16 , C07C237/50 , C07D205/04 , C07D207/09 , C07D207/12 , C07D211/74 , C07D211/82 , C07D211/86 , C07F9/06 , C07F9/106 , A61K2300/00
摘要： This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
摘要翻译： 本发明包括可离子化的化合物及其组合物及其使用方法。 可电离化合物可用于制备用于生物药物和治疗剂的纳米颗粒组合物。 更具体地说，本发明涉及用于提供纳米颗粒以包封活性剂（例如核酸试剂）的化合物，组合物和方法，并将活性剂递送和分配到细胞，组织，器官和受试者中。
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公开(公告)号：US09295728B2
公开(公告)日：2016-03-29
申请号：US13790995
申请日：2013-03-08
发明人： Kwok Yin Tsang , Hai Wang , Hao Bai , Yi Jin , Lei Yu
CPC分类号： A61K47/48207 , A61K47/645 , A61K49/146 , C08G69/10
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。
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公开(公告)号：US20220242820A1
公开(公告)日：2022-08-04
申请号：US17658075
申请日：2022-04-05
发明人： Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号： C07C271/16 , C07D205/04 , C07D207/12 , C07C237/16 , C07D207/09 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , A61K31/713 , C07F9/10 , A61K31/7105 , A61K9/127 , A61K9/51 , C07C237/08 , C07C237/50 , A61K47/16 , A61K47/22 , A61K47/24
摘要： Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号：US11384051B2
公开(公告)日：2022-07-12
申请号：US16228054
申请日：2018-12-20
发明人： Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号： A61K31/713 , A61K31/7105 , A61K9/127 , A61K9/51 , A61K47/16 , A61K47/22 , A61K47/24 , C07C271/16 , C07D205/04 , C07D207/12 , C07C237/16 , C07D207/09 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , C07F9/10 , C07C237/08 , C07C237/50
摘要： This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号：US10167253B2
公开(公告)日：2019-01-01
申请号：US15191511
申请日：2016-06-23
发明人： Roger Adami , Hao Bai , John Gaudette , Bharat Majeti , Seiji Nukui , Kwok Yin Tsang , Hai Wang , Haiqing Yin , Wenbin Ying
IPC分类号： A61K47/16 , A61K31/17 , A61K47/18 , C07C271/16 , C07D205/04 , A61K47/22 , C07D207/12 , C07C237/16 , C07D207/09 , C07D211/86 , C07D211/82 , C07D211/74 , C07F9/06 , A61K47/24 , A61K31/713 , C07F9/10 , A61K31/7105
摘要： This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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