公开(公告)号：US10195258B2

公开(公告)日：2019-02-05

申请号：US14166954

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION ,  OSAKA UNIVERSITY

Inventor： Yoshiki Maeda ,  Katsuyuki Okubo ,  Daisuke Asari ,  Arimichi Okazaki ,  Takuya Shishido ,  Mitsuhiko Hori ,  Haruo Sugiyama

IPC: A61K39/00 ,  A61K9/70

Abstract: The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support, an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.

公开(公告)号：US10449144B2

公开(公告)日：2019-10-22

申请号：US14166932

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION ,  OSAKA UNIVERSITY

Inventor： Katsuyuki Okubo ,  Yoshiki Maeda ,  Arimichi Okazaki ,  Daisuke Asari ,  Takuya Shishido ,  Mitsuhiko Hori ,  Haruo Sugiyama

IPC: A61K9/00 ,  A61K38/10 ,  A61K39/00

Abstract: The present invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.

公开(公告)号：US10071051B2

公开(公告)日：2018-09-11

申请号：US14166950

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION ,  OSAKA UNIVERSITY

Inventor： Katsuyuki Okubo ,  Yoshiki Maeda ,  Arimichi Okazaki ,  Daisuke Asari ,  Takuya Shishido ,  Mitsuhiko Hori ,  Haruo Sugiyama

IPC: A61K9/00 ,  A61K38/10 ,  A61K39/00 ,  A61K31/045 ,  A61K31/437 ,  A61K31/451 ,  A61K31/513 ,  A61K31/708 ,  A61K31/716 ,  A61K31/728 ,  A61K31/739

CPC classification number: A61K9/0014 ,  A61K31/045 ,  A61K31/437 ,  A61K31/451 ,  A61K31/513 ,  A61K31/708 ,  A61K31/716 ,  A61K31/728 ,  A61K31/739 ,  A61K38/10 ,  A61K39/0011 ,  A61K2039/54

Abstract: The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a pharmacologically acceptable acid as a first cellular immunity induction promoter, or a pharmacologically acceptable salt thereof.

公开(公告)号：US10688120B2

公开(公告)日：2020-06-23

申请号：US15570851

申请日：2016-04-28

Applicant: NITTO DENKO CORPORATION

Inventor： Kyohei Matsushita ,  Masahiro Fukasaka ,  Takuya Shishido ,  Daisuke Asari ,  Katsuyuki Okubo ,  Mitsuhiko Hori

IPC: A61K31/739 ,  A61K39/39 ,  A61K39/00 ,  A61K39/02 ,  A61K39/35 ,  A61P37/02 ,  A61P37/08 ,  A61P11/02 ,  A61P11/06

Abstract: The present invention provides an allergy vaccine composition that is useful as a prophylactic or therapeutic agent for an allergic disease and can safely and effectively induce immune tolerance. The vaccine composition is to be administered to a human or animal with an allergic disease for the prevention or treatment of the allergic disease. The vaccine composition contains: an immunomodulator which is a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt of the lipopolysaccharide; and at least one allergen.

公开(公告)号：US10471140B2

公开(公告)日：2019-11-12

申请号：US16388266

申请日：2019-04-18

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya Shishido ,  Daisuke Asari ,  Kyohei Matsushita ,  Mitsuhiko Hori

IPC: C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  A61K39/395 ,  C07H21/02 ,  A61K39/39 ,  A61K39/00

Abstract: The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

公开(公告)号：US10925936B2

公开(公告)日：2021-02-23

申请号：US15507443

申请日：2015-09-02

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya Shishido ,  Daisuke Asari ,  Mitsuhiko Hori

IPC: A61K39/00 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/355 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/663 ,  A61K31/675 ,  A61K31/685 ,  A61K33/00 ,  A61K31/42 ,  A61K31/192 ,  A61K31/12 ,  A61K9/70 ,  A61K38/00 ,  A61K31/19 ,  A61K31/4375 ,  A61K9/00 ,  A61K45/06 ,  A61K31/415 ,  A61K31/196 ,  A61K9/06 ,  A61K31/09 ,  A61K31/194 ,  A61K31/198 ,  A61K31/216 ,  A61K31/235 ,  A61K31/352 ,  A61K31/353 ,  A61K31/37 ,  A61K31/375 ,  A61K31/405 ,  A61K31/407 ,  A61K31/421 ,  A61K31/4745 ,  A61K31/5415 ,  A61K31/616 ,  A61K31/635 ,  A61K31/7048 ,  A61K33/04 ,  A61K38/10

Abstract: The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of cellular immunity against various antigens and exerting a high cellular immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing cellular immunity, containing: an antigen; and a first cellular immunity induction promoter that is a bisphosphonate.

公开(公告)号：US10722570B2

公开(公告)日：2020-07-28

申请号：US15777441

申请日：2016-11-28

Applicant: NITTO DENKO CORPORATION

Inventor： Eiji Kiyotoh ,  Mitsuhiko Hori ,  Daisuke Asari ,  Katsuyuki Okubo ,  Takuya Shishido ,  Masahiro Fukasaka ,  Kyohei Matsushita

IPC: A61K39/00 ,  C07K14/00 ,  C12N9/90 ,  A61K38/00 ,  A61K39/108 ,  A61K39/145 ,  A61K47/26 ,  A61K9/19 ,  A61K47/18 ,  A61P31/16

Abstract: The present invention provides a dried influenza vaccine preparation in which the activity of an influenza vaccine can be stably maintained even if the preparation is stored without strict temperature control and which can be stably supplied. The present invention also provides a method for producing the dried influenza vaccine preparation. Provided is a dried influenza vaccine preparation including: an influenza vaccine antigen; a disaccharide; and an amino acid.

公开(公告)号：US11278616B2

公开(公告)日：2022-03-22

申请号：US15932118

申请日：2016-08-03

Applicant: NITTO DENKO CORPORATION

Inventor： Kyohei Matsushita ,  Daisuke Asari ,  Takuya Shishido ,  Mitsuhiko Hori

IPC: A61K39/00 ,  A61K39/39 ,  A61K45/00 ,  A61P37/04 ,  A61K9/00

Abstract: The present invention provides an immunity induction-promoting composition which has a track record of use as a medicine or medicinal additive and is capable of safely and effectively inducing cellular immune response, and a vaccine pharmaceutical composition containing the immunity induction-promoting composition. The present invention relates to an immunity induction-promoting composition containing an immunity induction promoter whose active ingredient is an antimicrobial drug.

公开(公告)号：US10286067B2

公开(公告)日：2019-05-14

申请号：US15501271

申请日：2015-08-04

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya Shishido ,  Daisuke Asari ,  Kyohei Matsushita ,  Mitsuhiko Hori

IPC: A61K39/00 ,  C07K14/005 ,  C07H21/00 ,  C07H21/04 ,  C12N15/10 ,  A61K39/39

Abstract: The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

公开(公告)号：US10092505B2

公开(公告)日：2018-10-09

申请号：US13737255

申请日：2013-01-09

Applicant: NITTO DENKO CORPORATION

Inventor： Daisuke Asari ,  Mitsuhiko Hori ,  Takuya Shishido

IPC: A61K9/46 ,  A61K9/00 ,  A61K47/02

Abstract: The present invention provides an oral film-form base which has a rapid dissolution profile in the mouth and sufficient film strength, and gives an improved taking property by foaming in the mouth. The oral film-form base includes an edible polymer soluble both in water and in an organic solvent having a solubility parameter of 9.7 or higher, a foaming agent, and an auxiliary foaming agent, wherein the foaming agent is foamable in the presence of water, and the foaming agent and the auxiliary foaming agent each are insoluble in the organic solvent, have an average particle size of 0.1 to 60 μm, and are included in particle states.