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公开(公告)号：US11786168B2
公开(公告)日：2023-10-17
申请号：US16616898
申请日：2018-06-01
发明人： John A. Rogers , Johnathan T. Reeder , Amay J. Bandodkar , Sungbong Kim , Yurina Sekine , Jungil Choi , Tyler R. Ray , Aurelie Hourlier-Fargette , Philipp Gutruf , Kun Hyuck Lee , Milan Raj
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/1486 , A61B5/145 , A61B5/1477 , A61B5/01 , A61B5/103
CPC分类号： A61B5/4266 , A61B5/0022 , A61B5/01 , A61B5/1032 , A61B5/1455 , A61B5/1477 , A61B5/1486 , A61B5/14517 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B2562/0242 , A61B2562/0276 , A61B2562/164
摘要： The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.
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公开(公告)号：US11883165B2
公开(公告)日：2024-01-30
申请号：US17027887
申请日：2020-09-22
发明人： John A. Rogers , Jungil Choi , Tyler R. Ray , Johnathan T. Reeder , Yurina Sekine , Amay J. Bandodkar , Yi Zhang , Hexia Guo , Sungbong Kim , Diana Ostojich
CPC分类号： A61B5/14539 , A61B5/0002 , A61B5/053 , A61B5/1032 , A61B5/1455 , A61B5/14517 , A61B5/14546 , A61B5/4842 , A61B5/6806 , B01L3/502715 , A61B5/6833 , A61B2562/028 , A61B2562/164 , B01L2300/025 , B01L2300/0663 , B01L2300/0803 , B01L2300/0864 , B01L2300/123 , B01L2400/0406 , B01L2400/0688
摘要： A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.
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公开(公告)号：US11596329B2
公开(公告)日：2023-03-07
申请号：US16872522
申请日：2020-05-12
发明人： John A. Rogers , Jungil Choi , Sungbong Kim
摘要： The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.
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公开(公告)号：US10925523B2
公开(公告)日：2021-02-23
申请号：US16616770
申请日：2018-06-01
发明人： John A. Rogers , Jungil Choi , Tyler R. Ray , Johnathan T. Reeder , Yurina Sekine , Amay J. Bandodkar , Yi Zhang , Hexia Guo , Sungbong Kim , Diana Ostojich
摘要： Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.
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5.发明授权公开(公告)号：US10653342B2
公开(公告)日：2020-05-19
申请号：US15625087
申请日：2017-06-16
发明人： John A. Rogers , Jungil Choi , Sungbong Kim
摘要： The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.
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