公开(公告)号：US10259841B2

公开(公告)日：2019-04-16

申请号：US15306941

申请日：2015-04-30

Applicant: NOVOZYMES A/S

Inventor： Cedric Hobel ,  Heidi Winterberg Andersen ,  Peter Frode Pind ,  Cecilia Jansson Kepka

IPC: C12N9/26 ,  C12Q1/68 ,  C07K1/14 ,  C12N9/82 ,  C12N15/10

Abstract: A method for reducing the level of DNA in a fermentation broth is disclosed where the method includes a heating step where the broth is heated to a temperature of at least 70° C.

公开(公告)号：US20150291656A1

公开(公告)日：2015-10-15

申请号：US14438766

申请日：2013-11-01

Applicant: NOVOZYMES A/S

Inventor： Cedric Hobel ,  Cecilia Jansson Kepka

IPC: C07K1/30

CPC classification number: C07K1/30 ,  C07K1/14 ,  C12N15/1003

Abstract: A method for removing residual DNA from a fermentation broth comprising a protein of interest and a microorganism producing the protein of interest, said method comprising: a) adding a poly aluminium chloride to the fermentation broth, and b) separating the flocculated microorganism from the fermentation broth.

Abstract translation: 一种从包含感兴趣的蛋白质和产生目标蛋白质的微生物的发酵液中除去残留DNA的方法，所述方法包括：a）向发酵液中加入聚氯化铝，和b）将絮凝的微生物与发酵物分离 肉汤。

公开(公告)号：US20230225345A1

公开(公告)日：2023-07-20

申请号：US18151319

申请日：2023-01-06

Applicant: Novozymes A/S

Inventor： Cedric Hobel ,  Karen Jensen

IPC: A23C9/12 ,  C12N9/38 ,  A23C9/13

CPC classification number: A23C9/1206 ,  C12N9/2471 ,  A23C9/1322 ,  C12Y302/01023 ,  C12Y302/01108

Abstract: The present invention relates to a sterile-filtered liquid lactase preparation and to a method of sterile filtering a liquid lactase preparation.

公开(公告)号：US20180030087A1

公开(公告)日：2018-02-01

申请号：US15782282

申请日：2017-10-12

Applicant: NOVOZYMES A/S

Inventor： Cedric Hobel ,  Cecilia Jansson Kepka

IPC: C07K1/30 ,  C12N15/10 ,  C07K1/14

CPC classification number: C07K1/30 ,  C07K1/14 ,  C12N15/1003

Abstract: A method for removing residual DNA from a fermentation broth comprising a protein of interest and a microorganism producing the protein of interest, said method comprising: a) adding a poly aluminium chloride to the fermentation broth, and b) separating the flocculated microorganism from the fermentation broth.

公开(公告)号：US20240246842A1

公开(公告)日：2024-07-25

申请号：US18554192

申请日：2022-04-26

Applicant: Novozymes A/S

Inventor： Cedric Hobel ,  Alexander Findeisen ,  Sebastian Reinhold Soerensen ,  Pavle Andric ,  Nicholas Bagger Gurieff

IPC: C02F3/10 ,  C02F3/34 ,  C02F101/16 ,  C12N1/20 ,  C12N11/084

CPC classification number: C02F3/108 ,  C02F3/341 ,  C12N1/20 ,  C12N11/084 ,  C02F2101/163 ,  C02F2303/02

Abstract: A polymer support of immobilized microorganisms has been shown to be effective in reducing total nitrogen content, removing ammonia, nitrates and nitrites and suitable for the cleaning of wastewater and for the preparation and cleaning of drinking water.

公开(公告)号：US11576393B2

公开(公告)日：2023-02-14

申请号：US16473118

申请日：2018-01-12

Applicant: Novozymes A/S

Inventor： Cedric Hobel ,  Karen Jensen

IPC: A23C9/12 ,  A23C9/13 ,  C12N9/38

Abstract: The present invention relates to a sterile-filtered liquid lactase preparation and to a method of sterile filtering a liquid lactase preparation. At least 0.01% w/w of at least one salt having a monovalent cation is added in order to improve filterability. The system may further comprise a polyol stabilizer.

公开(公告)号：US20200221721A1

公开(公告)日：2020-07-16

申请号：US16473118

申请日：2018-01-12

Applicant: Novozymes A/S

Inventor： Cedric Hobel ,  Karen Jensen

IPC: A23C9/12 ,  C12N9/38 ,  A23C9/13

Abstract: The present invention relates to a sterile-filtered liquid lactase preparation and to a method of sterile filtering a liquid lactase preparation. At least 0.01% w/w of at least one salt having a monovalent cation is added in order to improve filterability. The system may further comprise a polyol stabilizer.

公开(公告)号：US20170044209A1

公开(公告)日：2017-02-16

申请号：US15306941

申请日：2015-04-30

Applicant: NOVOZYMES A/S

Inventor： Cedric Hobel ,  Heidi Winterberg Andersen ,  Peter Frode Pind ,  Cecilia Jansson Kepka

IPC: C07K1/14 ,  C12N9/82 ,  C12N15/10 ,  C12N9/26

CPC classification number: C07K1/14 ,  C07K1/145 ,  C12N9/2414 ,  C12N9/82 ,  C12N15/1003 ,  C12Y302/01001 ,  C12Y305/01001

Abstract: A method for reducing the level of DNA in a fermentation broth is disclosed where the method includes a heating step where the broth is heated to a temperature of at least 70° C.

Abstract translation: 公开了一种用于降低发酵液中DNA水平的方法，其中该方法包括加热步骤，其中将肉汤加热至至少70℃