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    Lipase variants for pharmaceutical use
    5.
    发明授权
    Lipase variants for pharmaceutical use 有权
    用于药物用途的脂肪酶变体

    公开(公告)号：US09539311B2

    公开(公告)日：2017-01-10

    申请号：US14679563

    申请日：2015-04-06

    Applicant: Novozymes A/S ,  Novozymes Inc.

    Inventor： Allan Svendsen ,  Michael Skjoet ,  Debbie Yaver ,  Lars Lehmann Hylling Christensen ,  Signe Eskildsen Larsen ,  Nina Lundin ,  Michael Lamsa ,  Peter Colin Gregory

    IPC: A61K38/47 ,  A61K38/48 ,  A61K38/54 ,  A61K38/46 ,  C12N9/20 ,  C12N9/14 ,  C12N9/26 ,  C12N9/48 ,  C07H21/04 ,  C07K1/00

    CPC classification number: A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  C12N9/20

    Abstract: The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, an are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.

    Abstract translation: 与包含SEQ ID NO：2的氨基酸1-269的Thermomyces lanuginosus（Humicola lanuginosa）脂肪酶相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 本发明的脂肪酶具有例如体外改进的消化性能，在中性范围内的pH值改善的活性，在低pH下的改进的稳定性，对蛋白酶降解是稳定的，和/或在存在时是稳定的 的胃蛋白酶和胆汁盐。 本发明还涉及确定脂肪酶的体外消化性能的方法以及T.lanuginosus的脂肪酶的某些新颖变体。

    Carbohydrate-Binding Modules of a New Family
    6.
    发明申请
    Carbohydrate-Binding Modules of a New Family 审中-公开
    新家庭的碳水化合物绑定模块

    公开(公告)号：US20150024465A1

    公开(公告)日：2015-01-22

    申请号：US14500564

    申请日：2014-09-29

    Applicant: Novozymes A/S

    Inventor： Kirk Matthew Schnorr ,  Lars Lehmann Hylling Christensen

    IPC: C12N9/42 ,  C07K14/37

    CPC classification number: C12N9/2437 ,  C07K14/37 ,  C12N9/2434

    Abstract: The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member of a new family of CBM's. The present invention further relates to CBM's preferably exhibiting binding affinity for cellulose; to a method of producing such CBM's; and to methods for using such CBM's in the textile, detergent and cellulose fiber processing industries, for purification of polypeptides, immobilisation of active enzymes, baking, manufacturing of biofuel, modification of plant cell walls.

    Abstract translation: 本发明涉及属于CBM新家族的非催化碳水化合物结合模块（CBM）。 发现本发明的CBM附着于糖基水解酶家族61（GH61）多肽，并且与已知的CBM具有很小的同源性，表明它是CBM新家族的第一个已知成员。 本发明还涉及CBM优选表现出对纤维素的结合亲和性; 一种生产这种煤层气的方法; 以及在织物，洗涤剂和纤维素纤维加工工业中使用这种CBM的方法，用于纯化多肽，活化酶的固定化，烘焙，制造生物燃料，修饰植物细胞壁。

    Protease variants
    10.
    发明授权
    Protease variants 有权
    蛋白酶变体

    公开(公告)号：US08772011B2

    公开(公告)日：2014-07-08

    申请号：US13738490

    申请日：2013-01-10

    Applicant: Novozymes A/S

    Inventor： Leonardo De Maria ,  Carsten Andersen ,  Lars Lehmann Hylling Christensen ,  Soren Flensted Lassen ,  Peter Rahbek Ostergaard

    IPC: C12N9/52 ,  A23K1/165

    CPC classification number: C12N9/58 ,  A01K2217/05 ,  A23K20/189 ,  C12N9/48 ,  C12N9/52 ,  C12N2310/111

    Abstract: The invention relates to a novel 3D structure encoding a Nocardiopsis protease, as well as to variants of parent protease homologous to Nocardiopsis proteases, preferably of improved thermostability and/or with an amended temperature activity profile. The invention also relates to DNA sequences encoding such variants, their production in a recombinant host cell, as well as methods of using the variants, in particular within the field of animal feed and detergents. The invention furthermore relates to methods of generating and preparing protease variants of amended properties.

    Abstract translation: 本发明涉及编码诺卡氏菌蛋白酶的新型3D结构，以及与诺卡氏菌蛋白酶同源的亲本蛋白酶的变体，优选具有改善的热稳定性和/或具有修改的温度活性分布。 本发明还涉及编码这些变体的DNA序列，其在重组宿主细胞中的产生，以及使用该变体，特别是在动物饲料和洗涤剂领域中的方法。 本发明还涉及生成和制备修饰性质的蛋白酶变体的方法。

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