公开(公告)号：US07955845B2

公开(公告)日：2011-06-07

申请号：US10850294

申请日：2004-05-20

申请人： Naoto Hirano ,  Marcus Butler ,  Lee M. Nadler

发明人： Naoto Hirano ,  Marcus Butler ,  Lee M. Nadler

IPC分类号： C12N5/071 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00

CPC分类号： C12N5/0639 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/70539 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/60 ,  C12N15/62 ,  C12N2740/13043 ,  C12N2740/16234 ,  C12N2760/16022 ,  C12N2760/16034

摘要： The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-presenting cells of the invention will provide a therapeutic strategy of modulating immune responses for a variety of diseases.

摘要翻译： 本发明涉及对所选抗原具有特异性的抗原呈递细胞和用于制备细胞的方法。 本发明还涉及使用报道融合构建体选择有效的抗原呈递细胞的方法。 本发明的高效抗原呈递细胞将提供调节各种疾病的免疫应答的治疗策略。

公开(公告)号：US20050003484A1

公开(公告)日：2005-01-06

申请号：US10850294

申请日：2004-05-20

申请人： Naoto Hirano ,  Marcus Butler ,  Lee Nadler

发明人： Naoto Hirano ,  Marcus Butler ,  Lee Nadler

IPC分类号： A61K38/00 ,  A61K39/12 ,  C07K14/47 ,  C07K14/74 ,  C12N5/02 ,  C12N5/0784 ,  C12N15/62 ,  C12N15/85 ,  C12N5/06

CPC分类号： C12N5/0639 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/70539 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/60 ,  C12N15/62 ,  C12N2740/13043 ,  C12N2740/16234 ,  C12N2760/16022 ,  C12N2760/16034

摘要： The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-presenting cells of the invention will provide a therapeutic strategy of modulating immune responses for a variety of diseases.

摘要翻译： 本发明涉及对所选抗原具有特异性的抗原呈递细胞和用于制备细胞的方法。 本发明还涉及使用报道融合构建体选择有效的抗原呈递细胞的方法。 本发明的高效抗原呈递细胞将提供调节各种疾病的免疫应答的治疗策略。

公开(公告)号：US5026139A

公开(公告)日：1991-06-25

申请号：US501144

申请日：1990-03-28

申请人： Stanley M. Klainer ,  Dileep K. Dandge ,  Marcus Butler ,  Kisholoy Goswami

发明人： Stanley M. Klainer ,  Dileep K. Dandge ,  Marcus Butler ,  Kisholoy Goswami

IPC分类号： G01N21/27 ,  G01N21/41 ,  G01N21/43 ,  G02B6/02

CPC分类号： G01N21/431 ,  G02B6/02 ,  G01N2021/432

摘要： A refractive index FOCS has a fiber optic core with a partly light transmissive thin metal film clad of an effective thickness and light transmissivity so that transmission through the core is strongly affected by the refractive index of a surrounding liquid or vapor medium. The metal clad and surrounding medium produce a localized refractive index at the core interface which modulates light transmission through the core as a function of the medium refractive index. The clad is made of platinum, or also of gold, rhodium, palladium, nickel, iron, cobalt, ruthenium, iridium, osmium, zinc, copper, silver, chronium, molybdenum, tungsten, vanadium, niobium, tantalum, titanium, zirconium or hafnium. The clad is also made of oxides of these metals, or metal compounds or alloys. With a fluorescent tip, the changes in the fluorescent signal are a measure of the medium refractive index. With a reflective tip, the changes in the reflected signal are measured. In a linear configuration, source and detector are placed at opposite ends of the fiber and changes in the transmitted signal are measured as a function of refractive index. Multiple measurements with multiple clads of different specificity can be made. The multiple clads can be on a single fiber or on separate fibers.

摘要翻译： 折射率FOCS具有具有有效厚度和透光率的部分透光的薄金属薄膜包层的光纤芯，使得通过芯的透射受到周围液体或蒸气介质的折射率的强烈影响。 金属包层和周围介质在核心界面处产生局部折射率，其作为介质折射率的函数调制通过芯的光透射。 包层由铂，或金，铑，钯，镍，铁，钴，钌，铱，锇，锌，铜，银，时代，钼，钨，钒，铌，钽，钛，锆或 铪。 包层也由这些金属的氧化物或金属化合物或合金制成。 使用荧光尖端，荧光信号的变化是介质折射率的量度。 使用反射尖端，测量反射信号的变化。 在线性配置中，源和检测器被放置在光纤的相对端，并且传输信号的变化被测量为折射率的函数。 可以进行具有不同特异性的多个囊的多个测量。 多个包层可以在单个纤维上或在单独的纤维上。