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    METHOD FOR EVALUATING REDOX ACTIVITY OF NUCLEIC ACID MOLECULE AND NUCLEIC ACID MOLECULE HAVING REDOX ACTIVITY
    1.
    发明申请
    METHOD FOR EVALUATING REDOX ACTIVITY OF NUCLEIC ACID MOLECULE AND NUCLEIC ACID MOLECULE HAVING REDOX ACTIVITY 有权
    用于评估具有还原活性的核酸分子和核酸分子的还原活性的方法

    公开(公告)号：US20140128589A1

    公开(公告)日：2014-05-08

    申请号：US14129392

    申请日：2012-07-02

    申请人： Naoto Kaneko ,  Katsunori Horii ,  Jou Akitomi ,  Shintarou Katou ,  Iwao Waga

    发明人： Naoto Kaneko ,  Katsunori Horii ,  Jou Akitomi ,  Shintarou Katou ,  Iwao Waga

    IPC分类号： C12N15/113 ,  G01N27/26 ,  G01N33/58

    CPC分类号： C12N15/113 ,  C12N15/1034 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/127 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2320/10 ,  C12N2330/31 ,  C12Q1/26 ,  C12Q1/6825 ,  G01N27/26 ,  G01N33/581 ,  C12Q2304/80 ,  C12Q2525/205 ,  C12Q2563/113

    摘要： The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion.includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.

    摘要翻译： 本发明提供可以评价核酸分子的氧化还原活性的新技术。 本发明的评价方法包括：使用电化学检测氧化还原反应的装置电化学检测对基底的氧化还原反应的检测步骤，所述氧化还原反应由待评价的核酸分子催化; 以及从检测氧化还原反应的结果来评价核酸分子的氧化还原活性的评价步骤。 作为该装置，包括具有检测部的基部的检测部。 包括电极系统，并且使用要评估的核酸分子设置在基底上。 在本发明中，优选在基材上排列要评价的多种核酸分子，通过单个装置评价要评价的多种核酸分子。

    Device and method for analyzing target
    2.
    发明授权
    Device and method for analyzing target 有权

    公开(公告)号：US09880174B2

    公开(公告)日：2018-01-30

    申请号：US14387389

    申请日：2012-12-12

    申请人： Katsunori Horii ,  Naoto Kaneko ,  Jou Akitomi ,  Shintarou Katou ,  Iwao Waga

    发明人： Katsunori Horii ,  Naoto Kaneko ,  Jou Akitomi ,  Shintarou Katou ,  Iwao Waga

    IPC分类号： G01N33/68 ,  C12Q1/00 ,  C12N9/08 ,  G01N21/59 ,  G01N33/53

    CPC分类号： G01N33/6845 ,  C12N9/0065 ,  C12Q1/008 ,  C12Y111/01007 ,  G01N21/59 ,  G01N33/5308 ,  G01N33/6812

    摘要： The present invention provides a novel sensor for detecting a target. The nucleic acid sensor of the present invention includes a nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to a target. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order. In this nucleic acid element, in the absence of a target, the catalytic function of the catalyst nucleic acid molecule (D) is inhibited by stem formation in each of the stem-forming sequences (SA) and (SD), and in the presence of ATP/target, the stem formation is released by a binding of the binding nucleic acid molecule (A) with the target, and the catalytic function is exerted.

    ANALYTICAL DEVICE AND ANALYTICAL METHOD
    5.
    发明申请
    ANALYTICAL DEVICE AND ANALYTICAL METHOD 审中-公开
    分析装置和分析方法

    公开(公告)号：US20130273530A1

    公开(公告)日：2013-10-17

    申请号：US13996389

    申请日：2011-12-22

    申请人： Katsunori Horii ,  Shintarou Katou ,  Jou Akitomi ,  Iwao Waga

    发明人： Katsunori Horii ,  Shintarou Katou ,  Jou Akitomi ,  Iwao Waga

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/68 ,  C12N15/111 ,  C12N2310/16 ,  C12N2320/10 ,  C12Q1/6834 ,  G01N33/54306 ,  C12Q2525/205 ,  C12Q2563/131

    摘要： The present invention provides a technique capable of simply analyzing a target to be analyzed. An analytical device of the present invention includes a basal plate; a nucleic acid element; and a detection section of detecting a signal. The nucleic acid element and the detection section are arranged on the basal plate. The nucleic acid element includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule is a nucleic acid molecule capable of binding to a target. The second nucleic acid molecule is a nucleic acid molecule capable of binding to streptavidin. When the target does not bind to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is inactivated. When the target binds to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is activated. The detection section detects binding between the second nucleic acid molecule and the streptavidin. The target is bound to the first nucleic acid molecule, so that the streptavidin is bound to the second nucleic acid molecule. Thus, the target can be analyzed through detecting the binding between the second nucleic acid molecule and the streptavidin using the detection device.

    摘要翻译： 本发明提供能够简单地分析要分析的靶的技术。 本发明的分析装置包括基板; 核酸元件; 以及检测信号的检测部。 核酸元件和检测部设置在基板上。 核酸元件包括第一核酸分子和第二核酸分子。 第一核酸分子是能够结合靶的核酸分子。 第二核酸分子是能够结合链霉亲和素的核酸分子。 当靶不与第一核酸分子结合时，第二核酸分子与链霉抗生物素蛋白的结合能力失活。 当靶标与第一核酸分子结合时，第二核酸分子与链亲和素的结合能力被激活。 检测部分检测第二核酸分子和链霉抗生物素蛋白之间的结合。 靶标与第一核酸分子结合，使得链亲和素与第二核酸分子结合。 因此，可以使用检测装置通过检测第二核酸分子和链霉亲和素之间的结合来分析靶。

    Nucleic acid molecule capable of binding to c-Met and use thereof
    9.
    发明授权
    Nucleic acid molecule capable of binding to c-Met and use thereof 有权
    能够结合c-Met的核酸分子及其用途

    公开(公告)号：US08822667B2

    公开(公告)日：2014-09-02

    申请号：US13812190

    申请日：2011-07-26

    申请人： Naomi Hirabayashi ,  Shotaro Tsuji ,  Jou Akitomi ,  Shintarou Katou ,  Iwao Waga ,  Takashi Ohtsu

    发明人： Naomi Hirabayashi ,  Shotaro Tsuji ,  Jou Akitomi ,  Shintarou Katou ,  Iwao Waga ,  Takashi Ohtsu

    IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00

    CPC分类号： C07H21/02 ,  A61K31/52 ,  A61K31/7105 ,  C12N15/115 ,  C12N2310/16 ,  C12Q1/6883 ,  C12Q2525/301 ,  C12Q2527/125 ,  A61K2300/00

    摘要： The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2). (A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38 (A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38 (B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76 (B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76.

    摘要翻译： 本发明提供能够结合c-Met的核酸分子，作为能够用于澄清由c-Met，疾病的诊断和治疗等引起的疾病的致病机制的物质，以及 使用它。 本发明的c-Met结合核酸分子是以下核酸分子（A1），（A2），（B1）和（B2）中的任一种。 （A1）包含SEQ ID NO：1至38（A2）中任一个的碱基序列的核酸分子，其能够结合c-Met并包含通过取代，缺失，加成获得的碱基序列 ，（SEQ ID NO：39）至（38）中的任何一个的碱基序列的核酸分子，和/或在SEQ ID NO：1至38（B1）中任一个的碱基序列中插入一个或多个碱基， 能够结合c-Met的核酸分子，并且包含通过SEQ ID NO：39至76中任一个的碱基序列中的一个或多个碱基的取代，缺失，添加和/或插入获得的碱基序列 。