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    Core-shell particle including signal-generating substance enclosed therein and process for producing the same
    1.
    发明授权
    Core-shell particle including signal-generating substance enclosed therein and process for producing the same 失效
    包含其中包含信号发生物质的核壳颗粒及其制备方法

    公开(公告)号：US06881484B2

    公开(公告)日：2005-04-19

    申请号：US10479247

    申请日：2001-05-30

    申请人： Kazunori Kataoka ,  Yukio Nagasaki ,  Naoya Shibata ,  Nobuhiro Hoshino

    发明人： Kazunori Kataoka ,  Yukio Nagasaki ,  Naoya Shibata ,  Nobuhiro Hoshino

    IPC分类号： G01N33/58 ,  B32B5/16

    CPC分类号： G01N33/585 ,  Y10S525/902 ,  Y10T428/2998

    摘要： A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed.The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.

    摘要翻译： 一种核 - 壳粒子，其中含有信号产生物质，其中所述核 - 壳粒子由（1）基本上由水不溶性聚合物化合物制成的核心部分组成; 和（2）基本由具有反应性官能团的水溶性高分子化合物制成的外壳部分，以刷毛的刷毛的方式覆盖芯部的表面; 并且核心部分和壳部分总体上是水不溶性聚合物和水溶性聚合物的嵌段共聚物，其特征在于，所述信号发生物质包括在芯部分中，并且公开了 还公开了其制造方法。 其中包含信号产生物质的核 - 壳颗粒可用作其中不需要具有处理限制的放射性同位素和不需要不稳定的酶的标记物质，实现了高于荧光物质的高灵敏度，并且不会发生非特异性吸收。

    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same
    2.
    发明授权
    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same 失效
    含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法

    公开(公告)号：US07470763B2

    公开(公告)日：2008-12-30

    申请号：US10539746

    申请日：2003-12-19

    申请人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    发明人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    IPC分类号： C08F12/04

    CPC分类号： C08F290/06 ,  A61K49/0414 ,  C08F2/44 ,  C08F290/00 ,  C08F290/02 ,  C08F290/062

    摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.

    摘要翻译： 本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质 或类似物。 所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same
    3.
    发明申请
    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same 失效
    含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法

    公开(公告)号：US20060138381A1

    公开(公告)日：2006-06-29

    申请号：US10539746

    申请日：2003-12-19

    申请人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    发明人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    IPC分类号： H01F1/26

    CPC分类号： C08F290/06 ,  A61K49/0414 ,  C08F2/44 ,  C08F290/00 ,  C08F290/02 ,  C08F290/062

    摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.

    摘要翻译： 本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质 或类似物。 所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

    Fluorescent substance- or contrast medium-containing latex polymer particles, and a process to produce the same
    4.
    发明申请
    Fluorescent substance- or contrast medium-containing latex polymer particles, and a process to produce the same 审中-公开
    含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法

    公开(公告)号：US20090179176A1

    公开(公告)日：2009-07-16

    申请号：US12292808

    申请日：2008-11-26

    申请人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    发明人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    IPC分类号： C09K11/08 ,  C09K11/02

    CPC分类号： C08F290/06 ,  A61K49/0414 ,  C08F2/44 ,  C08F290/00 ,  C08F290/02 ,  C08F290/062

    摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.

    摘要翻译： 本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质 或类似物。 所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

    Method of high-speed detection for biological analyte
    5.
    发明申请
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US20070059843A1

    公开(公告)日：2007-03-15

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。